Sentences with phrase «positive tumors»

Typically, ER - positive tumor growth is driven by the presence of estrogen.

Some ER - positive tumors respond to AI therapy, and some do not.

The goal is to develop personalized molecular tests that can predict how ER positive tumors will respond to various therapies.

The hormone estrogen fuels breast cancer cells in estrogen - receptor positive tumors.

Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy

Once word got out, 15 out of 30 million women in America taking HRT stopped; by 2007, invasive breast cancer in women over 50 for estrogen - receptive positive tumors dropped 11 percent.

In all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, right).

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

These five - year results demonstrate positive tumor control and disprove the misconception that short - course treatment will result in late - appearing, unacceptable toxicities.»

ER - positive tumors comprise two «intrinsic subtypes»: Luminal A, which generally has a favorable prognosis, and Luminal B, which generally has a worse prognosis.

Although ER - positive tumors represent the majority of breast cancer cases, they exhibit a wide range of prognoses, histological growth patterns, and treatment outcomes.

«These results prospectively show for the first time that positive tumor expression of pSTAT3 is a poor prognostic factor in patients with metastatic colorectal cancer.»

The conjugate, which they named «chemocoxib A,» reduced growth of COX - 2 positive tumors in mice by 50 percent, but didn't have any effect on tumors that didn't express the enzyme.

«This innovation has the potential to dramatically enhance long - term outcomes and quality of life for patients by preserving kidney function and saving lives by more accurately removing masses and reducing positive tumor margin rates.»

The single ER - positive tumor with MELK amplified is also positive for HER2 expression.

For years, breast cancer researchers have known that women whose breast cancers contain both estrogen receptors and progesterone receptors (known as ER positive / PR positive tumors) have better treatment outcomes than women whose tumors do not have these receptors.

These associations were primarily limited to hormone receptor — positive tumors as migraine was associated with a 0.65-fold (95 % CI, 0.51 - 0.83) reduced risk of estrogen receptor — positive (ER +) / progesterone receptor — positive (PR +) ductal carcinoma.

Also, we know hormone receptive positive tumors are much more sensitive to radiation, which could explain why we found the survival benefit in this group of patients.»

Serap Günes (TUD)-- «Modification of vesicular stomatitis virus G protein for targeted gene delivery into PSCA - positive tumor cells» (2007)

No associations were found for women with hormone - receptor - positive tumors and for women who received endocrine therapy.

The mice are particularly good models of estrogen receptor - positive tumors (so named because they are fueled by estrogen) that have become resistant to the drugs used to treat them.

The researchers found that OTL38 accumulated in FRα - positive tumors and metastases, and enabled the surgeons to remove an additional 29 percent of malignant lesions (confirmed by pathological examination of the resected tumors) that could not be identified with naked eyes and / or palpation.

In the featured article of The Journal of Nuclear Medicine's October issue, German researchers report on their recent clinical experience, which establishes a dosing regimen for actinium - 225 (225Ac)- labeled targeted alpha therapy of patients with prostate specific membrane antigen (PSMA)- positive tumors.

The new technology was tested in mice for the ability to generate antibodies in their blood stream that would target human PSMA as well as target PSMA - positive tumors.

A Phase II Basket Study of the Oral TRK Inhibitor LOXO - 101 in Subjects with NTRK Fusion - Positive Tumors

However, these tumors may display intrinsic or acquired resistance to treatment, and classifiers of HER2 - positive tumors are required to improve the prediction of prognosis and to develop novel therapeutic interventions.

While this trial - s primary efficacy goals are to evaluate anti-tumor activity in PD - L1 positive tumors, preliminary exploration of antitumor activity will also be conducted in a subset of PD - L1 negative tumors based upon response observed in PD - L1 positive tumors or lymphoma in this trial.

A prespecified biomarker analysis found that patients with pSTAT3 - positive tumors had significantly improved overall survival when treated with napabucasin compared with placebo (median, 5.1 vs 3.0 months; hazard ratio, 0.41; 95 % CI, 0.23 — 0.73; P =.0025).

Napabucasin did not increase overall survival compared with placebo in the overall population of patients with advanced colorectal cancer in the study, but did significantly improve survival among patients with phosphorylated STAT3 (pSTAT3)- positive tumors.

«HER2 - positive, ER - positive tumors have molecular features distinct from those of HER2 - positive, ER - negative cancers, suggesting that the two types of tumors should be treated with differently tailored approaches,» wrote study authors led by Luca Gianni, MD, of San Raffaele Scientific Institute in Milan.

Finally, our peptides have been used by other groups to deliver conjugated imaging agents, drugs and nanoparticles to Eph receptor - positive tumors.

Our findings suggest that this is also true in breast cancer as EGFR inhibition blocked the hypoxic CSC effect in ER - α — positive tumors.

These results challenge whether women at risk for secondary breast cancer after chest RT for Hodgkin lymphoma should be universal candidates for chemopreventive agents, such as selective estrogen receptor modulators or aromatase inhibitors, which are only effective in preventing ER - positive tumors.

May 16, 2018 • An aggressive type of breast cancer — a HER2 - positive tumor — often shrinks with Herceptin treatment, but side effects can be tough.