Sentences with phrase «protein trafficking»
Protein trafficking refers to the process by which proteins are moved or transported within a cell to specific locations, like different compartments or organelles. It's like a protein delivery system that ensures proteins are taken to the right place where they are needed for various functions in the cell. Full definition
Selective imaging by correlated optical and electron microscopy of protein molecules of known ages will clarify fundamental processes of protein trafficking in situ.
science.sciencemag.org
Pathways and mechanisms of protein trafficking in polarized epithelia; Wilson and Menkes Diseases; copper ATPases
Then, the research group examined the molecular mechanism behind the impaired synaptic functions and behaviors in ARHGAP33 KO mice and found that ARHGAP33 is localized to the Golgi apparatus to regulate intracellular protein trafficking of the Tropomyosin receptor kinase B (TrkB) receptor, a neurotrophin receptor, to synaptic sites.
Pharmacologic Approach to Defective Protein Trafficking in the E637K - hERG Mutant with PD - 118057 and Thapsigargin
The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.
Host: Dr. Lynn Raymond Speaker: Dr. Katherine Roche, NIH / NINDS Title: Molecular Mechanisms Regulating Protein Trafficking at Excitatory Synapses
«Gene discovered to cause rare, severe neurological disease: Epileptic encephalopathy linked to protein trafficking gene.»
Protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus involves specific uptake into coat protein complex II (COPII)-- coated vesicles of secretory and of vesicle targeting (v - SNARE) proteins.
The group» finding that the impaired intracellular protein trafficking leads to neuropsychiatric disorders - related abnormal higher brain functions has high impact on the fields of psychiatry, basic medical sciences, and pharmaceutical sciences.
Some motor neuron diseases are also associated with disruption of motor protein traffic.
In Chlamydomonas, we can initiate cilia formation experimentally, which allows us to see cilia during construction and analyze protein traffic while they are made.»
Raised on the knee of science — her father taught her and her two brothers from a young age about geology, physics, and natural history — Alice Ting now stands firmly on her own two feet among the faculty at MIT's Chemistry Department, where her objective is to «simultaneously harness the power of genetics and the power of chemistry» using new technologies developed in her lab for imaging protein trafficking, protein - protein interactions, and enzymatic activity.
To overcome these limitations, we are developing innovative electron microscopy techniques to visualize membrane and protein trafficking events at millisecond temporal resolution.
Wild - type huntingtin participates in protein trafficking between the Golgi and the extracellular space.
Eric is a molecular and cellular biologist studying functions of the ubiquitin system, which, selectively targets proteins to be degraded by the proteasome, orchestrates responses to various stresses, and controls protein trafficking.
The research group showed that a molecule, ARHGAP33 regulates synaptic functions and behaviors via intracellular protein trafficking and that the lack of ARHGAP33 causes neuropsychiatric disorder - related impaired higher brain functions.
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome.
His graduate work focused on the molecular mechanisms of DNA replication and protein trafficking in mitochondria, and the translational control of novel mitochondrial protein isoforms.
2004 — Natasha Raikhel — for her studies of protein trafficking and for developing the model plant Arabidopsis thaliana as the organism of choice for plant cell biology
A research group led by Osaka University and the University of Tokyo found that the intracellular protein trafficking is important for higher brain functions such as learning and memory.
Immature proteins are degraded before they can take up the task, suggesting that protein trafficking to the outer membrane is tightly regulated.
The gene is also involved in protein trafficking — the routing of proteins to their proper destination within cells.