Sentences with phrase «pyramidal neurons»

Ankyrin - G is normally found in pyramidal neurons in the brain of mammals, including people.

Hand R *, Bortone D *, Mattar P, N'Guyen L, Heng JI - T, Guerrier S, Boutt E, Peters E, Barnes, AP, Parras C, Schuurmans C, Guillemot F and Polleux F. (2005) Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex.

It receives information via the so - called mossy fibres (MF), which originate in dentate gyrus neurons and, together with pyramidal neurons, form synapses in CA3; in this case MF - CA3 - synapses.

Discovered that Kv7 / M / KCNQ - type K + channels are present in the perisomatic region but not in the apical dendrites of hippocampal pyramidal neurons (Hu et al., J. Neuroscience, 2007).

Left: Reconstruction of pyramidal neurons from mouse primary visual cortex.

In GluR - A — deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-- tagged GluR - A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons.

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

Chandelier cells tune the activity of pyramidal neurons by releasing the inhibitory transmitter GABA through complex arrays of connections called cartridges.

At hippocampal excitatory synapses on pyramidal neurons the cannabinoid - induced synaptic suppression was reversed by a CB1 - specific antagonist, N -(piperidin -1-yl)-5 -(4 - iodophenyl)-1 -(2,4 - dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), and was absent in CB1 knock - out mice.

In particular, what are the molecular mechanisms underlying the ability of long - range projecting pyramidal neurons and locally - projecting interneurons to form an axon, for these axons to grow and branch and finally find their appropriate synaptic targets?

Synaptic reconstruction of all excitatory inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation (Unpublished, Dan Iascone)

Arrow heads point to two of the chandelier cell soma or cell bodies, from each of which hundreds of candelabra - like arbors reach out to connect with local pyramidal neurons in a part of the cerebral cortex.

The new research reveals how spatially intermixed pyramidal neurons that were associated with single chandelier cells in the mouse prelimbic cortex segregated into two groups.

Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade.

Right: Illustration of simplified pyramidal neuron models.

«What we found at the cellular level correlates with the behaviors we saw in the less - anxious, hyper - active mice, which means having overactive pyramidal neurons with their brakes removed could be contributing to these behaviors,» says Zhu.

Similar compelling evidence supporting the existence of bonafide intraneuronal Aβ peptides has been provided by ELISA analysis on laser microdissected pyramidal neurons from sporadic AD cases [63].

Although pyramidal neurons have been always considered the backbone of the cortex and therefore dominated the interest of neuroscientists, a century ago, Ramòn y Cajal has predicted that interneurons, or as he called them, the butterflies of the soul, are responsible for refining cortical processing.

At 13 months of age, the intracellular MOAB - 2 immunolabel was hardly detectable in pyramidal neurons adjacent to amyloid plaques, the latter which were strongly labeled by this antibody and not by pab27576 (Additional file3: Figure S2 a-b).

Ex vivo cortical electroporation (E15 mouse embryos) coupled with organotypic culture for 5 days results in radial migration of EGFP + pyramidal neurons to the cortical plate (CP) and the projection of their axon in the intermediate zone (IZ).

Involved in cannabinoid - dependent depolarization - induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (PubMed: 22388959).

Chia - Shan Wu, Jie Zhu, Jim Wager - Miller, Shan Wang, Dennis O'Leary, Krisztina Monory, Beat Lutz, Ken Mackie, and Hui - Chen Lu (2010) «Requirement of cannabinoid CB1 receptor in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections», European J. Neuroscience, 32:693 - 706.

Immunohistochemical examination of postmortem AD brains revealed that cytoplasmic accumulation of 8 - oxoG is evident in hippocampal CA1 and CA3 pyramidal neurons, and in neurons in the temporal cortex, where Aβ is also highly accumulated.

Synaptic reconstruction of all excitatory and inhibitory inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation.

When they mutated neuregulin 3 in neurons that help activate the brain — called pyramidal neurons — the genetically modified mice displayed behavior consistent with schizophrenia.

Zhong, P. & Yan, Z. Differential regulation of the excitability of prefrontal cortical fast - spiking interneurons and pyramidal neurons by serotonin and fluoxetine.

Synaptogenesis and development of pyramidal neuron dendritic norphology in the chimpanzee neocortex resembles humans.

To further characterize the distribution of McSA1 and pab27576 signals, pyramidal neurons from lamina III and lamina V of the parietal cortex were imaged by SIM in 3 - month old amyloid - plaque free transgenic rats.

Molecular profiles of pyramidal neurons in schizophrenia.

For example, a deep layer 5 pyramidal neuron might snake its gossamer - thin output wire, the axon, to a subcortical target area while also extending a connection to an inhibitory local neuron.

The neurons shown here are pyramidal neurons, so called because of their triangle - shaped cell bodies.

Because each chandelier cell may control the firing of hundreds of pyramidal neurons, it has been suggested that they exert a kind of «veto» power over local excitatory messages.

At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are postulated to be necessary for the induction of long - term potentiation and depression, respectively — forms of plasticity thought to underlie associative learning.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

To circumvent that problem, the researchers generated their new mouse so that ankyrin - G would only be lost in the pyramidal neurons found in the front of the brain (the region believed to be most relevant for psychiatric disorders) in adolescent and adult mice.

The UAB researchers first showed that inhibition of DNA methyltransferases, or DNMTi, with the drug RG108 for 24 hours increased the IME of cultured rat cortical pyramidal neurons, as shown by current - clamp electrophysiology.

The experiments are consistent with the idea, Zhu says, that the pyramidal neurons in the mutants seem to be hyperactive.

To see if the loss of ankyrin - G in the pyramidal neurons changed the animals» behavior, the researchers used tests including a so - called «open field» test to see how the mice acted when placed in an empty chamber.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.