The finding will allow researchers to refine their search for new influenza strains and manufacture a
yearly vaccine designed to give recipients resistance to the right ones.
Although the data are limited, the results have implications for novel
influenza vaccine design, according to the authors.
«New findings to help HIV scientists establish «template» for potent antibodies: Natural - infection studies in Africa and India continue to inform
HIV vaccine design.»
This antibody may be used for passive protection and to
inform vaccine design because of its broad specificity and neutralization potency.
William Schief is a Professor in the Immunology and Microbial Science Department at The Scripps Research Institute in La Jolla, CA, Director
for Vaccine Design at the International AIDS Vaccine Initiative (IAVI), and an Associate Member of the Ragon Institute of MGH, MIT and Harvard.
The primary focus will be to work as a member of the team responsible for delineating the immune response against nairoviruses to aid
effective vaccine design.
By defining the gene expression signature of CD4 - CTLs and their precursors, their studies should facilitate
improved vaccine design in the context of chronic viral infections.
Numerous
experimental vaccines designed to ward off infections such as Japanese encephalitis virus, herpes simplex virus, and B cell lymphoma, and even to counter cocaine addiction, are under evaluation.
He is also a founder and board member of CompuVax, Inc., a startup biotech company focused
on vaccine design.
Dr. Schief's work focuses on computation - guided and structure - based design of immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and other pathogens that have frustrated
traditional vaccine design strategies.
«The promising results show that personalised
cancer vaccines designed to treat skin cancer are safe to use, and that for some patients, they can successfully harness the power of the body's own immune system to kill cancer cells,» Pickworth added.
She is involved
with vaccine design and efficacy screening in different models of mycobacterial infections.
Led by scientists at the International AIDS Vaccine Initiative (IAVI) and The Scripps Research Institute (TSRI), the results offer important insight into a potential
AIDS vaccine design.
GSK markets 39 pediatric, adolescent, adult, and
traveler vaccines designed to protect against 21 diseases, including hepatitis, meningitis, influenza, pneumococcal disease, and rotavirus.
The vaccine tested in Cape Town in 2013 was MVA 85A, a modification of the
cowpox vaccine designed to express a major protein of the TB bacterium.
«The emergence of Zika virus has further
complicated vaccine design, and emphasizes the need to better understand the molecular mechanisms that underpin protective antibody responses.»
Unlike any
other vaccine designed for human use, this product would be a DNA vaccine that only contains a particular part of the pathogen (rather than a vaccine with an inactivated live or dead virus, for example).
Still, it «was a direct validation of Ralph's concept,» says Kalinski, and
vaccines designed more recently, he believes, are working better.
Two
investigational vaccines designed to protect against Ebola virus disease were well - tolerated and induced an immune response among 1,000 vaccinated participants in the Phase 2 randomized, placebo - controlled clinical trial called PREVAIL I.
«I mean, we're working in things
like vaccine design and computational biology, quantum computing.»
A potential
successful vaccine design might protect by eliciting broadly neutralizing antibodies (bNAbs), which target specific regions on HIV - 1's trimeric envelope glycoprotein (Env)(see the Perspective by Mascola).
Two studies published on July 9th in PLOS Pathogens provide results on Nabs that could help
guide vaccine design.
«To understand the factors behind T - cell - receptor binding to peptides will have major impact on biomedical developments,
including vaccine design and immunotherapy.»
One key to reaching those goals, says Dr. Steinman, is to
shift vaccine design research from what he considers guesswork to something more reliable and predictable.
Comprehensive knowledge about the evolution of Dengue in response to selection pressure is currently unavailable, but would greatly
enhance vaccine design efforts.
More to the point, by genetically stripping dengue virus of its ability to bind 14 -3-3 epsilon, Gack has generated a crippled virus that can elicit a strong human immune response, providing a framework for
rational vaccine design against emerging infectious diseases.
Career Goals: I plan to pursue a career in scientific research focused on understanding the human immune response to various infectious agents for diagnostic and
vaccine design purpose.
Another is from Seattle global health writer Tom Paulson, on immunologist Bali Pulendran and using systems biology to unlock new insights
into vaccine design.
Physicians with the Personalized Medicine Program at The Tisch Cancer Institute have initiated a phase I proof - of - concept study, a fully personalized multipeptide
therapeutic vaccine designed to target tumor - derived neoantigens for individual patients.
The US Department of Agriculture has
approved vaccines designed to address outbreaks and control CIV H3N2 in the canine population.
The Heska Corporation of Ft. Collins Colo. has just launched two new
intranasal vaccines designed to protect cats against feline panleukopenia, rhinotracheitis and calicivirus.
The finding could ultimately help improve
flu vaccine design: Because it takes time to manufacture vaccines and inoculate the public, scientists must choose which strains to target many months before the year's flu season begins.
The TSRI scientists are continuing to study bnAbs against HIV for clues to an
effective vaccine design, but as new candidate vaccines are developed, targeting V2 apex glycans is likely to be a high priority.
The findings, published in the January 19, 2018, online edition of Science Immunology, provide new insights into how so - called CD4 cytotoxic T cells arise in humans and thus could facilitate
improved vaccine design to protect against chronic viral infections such as cytomegalovirus, HIV, and hepatitis C.
«The study also illustrates increasing African leadership in HIV vaccine research, a prerequisite for successful long - term collaborative studies on HIV acute infection to
inform vaccine design.»
An
experimental vaccine designed to spur production of antibodies against a key malaria parasite protein, AMA1, was developed more than decade ago by scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
At the start, researchers pinned their hopes
on vaccines designed to trigger production of antibodies against HIV's surface protein.
This approach represents a departure from
traditional vaccine designs, which have been developed and tested against HIV in vulnerable populations since the mid-1980s without success.
AST - VAC2 is an allogeneic (non-patient specific)
cancer vaccine designed to stimulate patient immune responses to telomerase, which is expressed in over 95 % of human cancers but is rarely expressed in normal adult cells.