Sentences with phrase «additional genes»

There is evidence that the expression of hundreds of additional genes in adult rats changes in response to differences in maternal care [19].

These links have now been verified again and again, and scientists are searching for additional genes that might play a role in this exquisite childhood sensitivity.

This research includes identifying additional genes associated with disease incidence in order to identify potential drug targets.

That could be done by changing the genetic code, adding additional genes or changing the expression of a gene in the code.

I'm not certain what you mean by «genetic information», because additional genes and new gene sequences are generated all the time.

She is scanning the genomes of individuals in the current study to identify regions that may contain additional gene candidates.

However, epigenetic changes at a single gene promoter are unlikely to account for the range of outcomes and the persistent change in expression of hundreds of additional genes in adult rats in response to differences in maternal care.

The next steps in the research include studying salivary composition in cleft lip or palate patients, as well as additional genes associated with cleft lip or palate to determine if they contribute to abnormal development of the salivary glands.

The scientists found additional genes associated with hair including EDAR for beard thickness and hair shape; FOXL2 for eyebrow thickness and PAX3 for monobrow prevalence.

A family of neuropeptide genes which includes the gene encoding ELH along with two additional genes encoding the A and B peptides thought to initiate the egg - laying process has been isolated and their nucleotide sequence has been determined.

But she cautions that the inebriometer measures only one simple behavior — passing out — and that more complex aspects of tolerance, such as cognitive impairment, may involve additional genes.

«But if we can add additional genes into the screening, we can refine the prediction of the disease, we can increase the accuracy, we can probably even identify higher percentages of at - risk individuals.»

When the researchers analyzed DNA from 16 of the dogs and eight of the wolves, the behavioral differences turned out to be correlated with variations in three genes — the WBSCR17 gene highlighted in the 2010 study, and two additional genes from within the canine equivalent of the Williams syndrome region.

If Rudenko confirms Clark's PCR tests using additional gene targets, and if Clark or Rudenko manage to grow Borrelia cultures out of human and lone star tick samples, then even the fiercest skeptics will have to recognize that Southern Lyme strains threaten human health, and that Lyme - like illness deserves Lyme - like treatment.

Apparently, NPAS4 accounts for some addiction - related learning and memory processes in the brain, but not all of them, meaning that HDAC5 must be regulating additional genes that reduce relapse events.

Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

«This allows for continuous integration of additional gene features as our knowledge base improves,» added Dr. Steidl.

«With ongoing studies of the homologous recombination pathway and its impact on cancer development, we may identify additional genes that, when mutated, allow for either improved response to specific treatments or conversely, portend more aggressive tumor biology, and this could greatly inform development of new cancer therapies,» Heeke explains.

Aside from increasing the known gene pool of giant viruses by nearly 2,500 additional gene families, comparing the genes to previously discovered giant viruses revealed that the Klosneuviruses are a subfamily of Mimiviruses.

However, differences in genomic make - up between African ancestry and other populations have uncovered additional genes affecting blood pressure, in addition to genetic variants that are specific to individuals of African ancestry,» said Nora Franceschini, MD, MPH, nephrologist and research assistant professor of epidemiology at the University of North Carolina at Chapel Hill and first author on the paper.

If a woman with a strong family history of breast and ovarian cancers tests negative for the BRCA1 / 2 genes, that does not mean her relatives are not at risk, says Daly — her siblings could still carry the gene, or there could be additional genes present that predispose them to cancer that clinicians don't yet know how to test for.

Scientist from the MPI for Heart and Lung Research in Bad Nauheim now found that additional genes compensate for a knocked out gene and either attenuate consequences or completely compensate deficits.

With the development of modern genomics sequencing tools, the discovery of additional genes implicated in breast cancer and the change in the legal status of genetic testing for BRCA1 and BRCA2, it is now possible to determine how often families in these circumstances actually do carry cancer - predisposing mutations in BRCA1, BRCA2, or another gene implicated in breast cancer, despite the results of their previous genetic tests.

But they provide additional gene markers in bipolar disorder that could potentially lead to the future development of diagnostics or treatments.»

Here we show that these cells exhibit decreased mRNA levels for additional genes contributing to telomere metabolism, but also, surprisingly, for 12 genes mutated in Fanconi anaemia.

When the researchers looked at the role of genes that were methylated by genes with code differences related to ASD, including additional genes beyond those with direct code changes, they found that the majority were involved in biological pathways that were important in immune function.

By 2008, when Moir stumbled on the parallels between amyloid - beta and LL - 37, Tanzi had discovered additional genes associated with Alzheimer's that were also related to innate immunity, the part of the human immune system that is shared with worms, flies, spiders and other primitive creatures.

Trisomy 21 means that there are three copies of chromosome 21, and while not included in the CNV classification, it demonstrates the effects that can occur when additional gene copies are present on a massive scale.

Research has suggested that there may be as many as a dozen additional genes that play a role in breast cancer predisposition.

In a new study led by Tobias Sjöblom (Uppsala University / SciLifeLab), a large - scale search for genetic mutations in human colorectal cancer cells made it possible to assign additional genes to intracellular pathways of clinical importance for the disease.

Vogelstein has gone on to investigate additional genes involved in colon cancer such as APC, mutations of which lead to colorectal tumors, and PIK3CA, whose mutations turn benign tumors malignant.

We modeled how additional genes would impact the assay by looking at the inclusion of other amplicons from the top 20 genes contributing to bladder cancer development listed in the COSMIC database.

To find additional genes that regulate fusion, Millay's team screened for those activated by expression of a protein called MyoD, which is the primary initiator of the all the genes that make muscle.

Testing for additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.

This elevation delayed the expression of additional genes associated with the consolidation of memory — i.e. the creation of long - term stable memory.

Additional genes in the population or other factors that remain to be determined, can delay the effects of the cord1 mutation in some dogs.

The first steps in this have already been accomplished with the transplanting of additional genes for growth hormone into sheep in Australia to produce larger animals and therefore more wool.

The researchers identified several reasons for this: The new gene constructs interfere with the plant's own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves.

«The result was TransposeNet, a new suite of computational tools that uses machine learning algorithms to visualize patterns and interaction networks based on genes that are highly conserved from yeast to humans — and then makes predictions about the additional genes that are part of the alpha - synuclein toxicity response in humans.»

Many other genes have been linked to cleft lip or palate, and the researchers hope to understand if these additional genes are also associated with enhanced tooth decay.

They calculated evolution rates for 12 additional genes, and — most importantly, they say — eliminated from their pool both slowly and rapidly evolving species that might have skewed their average.

Although the study doesn't point to immediate treatment possibilities, Heitman says that many researchers are studying the mechanisms that allow cells to tolerate the many extra proteins produced by the additional genes, which might reveal a weakness to target.

However, not all dogs with the mutation became affected, prompting the hypothesis that additional genes could modify disease risk.

«We generated over 600 engineered tobacco plant lines that harbour different combinations of these additional genes, and analysed them in terms of the amounts of artemisinic compounds they acquired.