Sentences with phrase «cell dysfunction»

This gene is used in every cell of a person's body, and yet HD occurs when specific brain cells dysfunction and, eventually, die.

The beta cell dysfunction caused the high blood sugars, not the other way around.

Not until after beta cell dysfunction develops does the glucose go way up.

The progressive decline in insulin production is often called beta cell dysfunction or sometimes pancreatic burnout.

His plans for research in his own lab involve «continuing to look at the mechanisms of T cell dysfunction in human and mice.

«Despite clear potential benefits for individuals with T1D, research into human alpha cell dysfunction within the context of T1D has been underappreciated and underfunded,» said Dr. Ben Williams, Program Officer of Helmsley's Type 1 Diabetes Program.

The latter substance, phosphorylated tau, is responsible for neurofibrillary tangles, which are suspected of contributing to the nerve cell dysfunction in the brain that is responsible for Alzheimer's memory symptoms.

This suggests to us that B cell dysfunction in early development may contribute to later mental disorders, a possibility that we believe deserves further exploration in future studies.»

Unravelling this mechanism could also help scientists understand more about human cell dysfunctions linked to disorders such as diabetes, Parkinson's and other neurodegenerative diseases.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8 + T cells, with implications for defining a biomarker of T cell dysfunction and a target for immunotherapeutic intervention.

Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis.

F In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or osteoblastic differentiation.

The disease is characterized by profound fatigue and disability lasting for at least 6 mo, episodes of cognitive dysfunction, sleep disturbance, autonomic abnormalities, chronic or intermittent pain syndromes, microbiome abnormalities (1), cerebral cytokine dysregulation (2), natural killer cell dysfunction (3), and other symptoms that are made worse by exertion of any kind (4).

«We found that PV cells in patients with Alzheimer's and in AD - mice have low levels of the protein Nav1.1 — likely contributing to PV cell dysfunction.

However, in diabetes pathogenesis beta cell dysfunction hinders functional compensation resulting in hyperglycemia.

These findings indicate that amylin fibril formation in the pancreas may cause islet cell dysfunction and death in type - 2 diabetes mellitus.

This finding correlates with studies that show similar cell dysfunction in arteries and an increased risk of stroke in OSA patients.

Stitzel and his team showed that HADH is also expressed by delta cells and that delta cell dysfunction might be a previously unrecognized contributing factor to monogenic diabetic disorders.

Review Panel Member, Protective Agents in Neural Cell Dysfunction, U.S. Army Medical Research and Materiel Command

«We are interested in how stem cells maintain and repair the epidermis and how stem cell dysfunction leads to tumorigenesis», said Maria Kasper.

In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies.

University of Miami, «Pilot studies to understand alpha cell dysfunction and correct glucagon secretion in type 1 diabetes,» led by Dr. Alejandro Caicedo

A better understanding of aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target for therapy, according to the authors.

Maccari ME, Scarselli A, Di Cesare S, Floris M, Angius A, Deodati A, Chiriaco M, Cambiaso P, Corrente S, Colafati GS, Utz PJ, Angelini F, Fierabracci A, Aiuti A, Carsetti R, Rosenberg JM, Cappa M, Rossi P, Bacchetta R, Cancrini C. Severe toxoplasma gondii infection in a member of a NFKB2 - deficient family with T and B cell dysfunction.

Emk -LRB-- / --RRB- mice displayed growth retardation and immune cell dysfunction.

By reprogramming human skin cells and other cells from patients with neurologic and psychiatric diseases into induced pluripotent stem cells (iPSCs) and induced neurons (iN), his work seeks to decipher the progression and mechanisms that lead to brain cell dysfunction.

Research Interests: One - carbon metabolism; methionine cycle; transsulfuration; micronutrients; vitamin B12 (cobalamins); folates; homocysteine; homocystinuria; hyperhomocysteinemia; diagnosis of cobalamin deficiency; atherogenesis; endothelial cell dysfunction; alcoholic liver disease; biomarkers of one - carbon metabolism.

In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or osteoblastic differentiation.

Studies associated with the Wanek Family Project will derive new innovations to correct the beta cell dysfunction in diabetes.

Research Interests: Tumor immunity, T lymphocyte effectors, immunotherapy, T - cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

It should be noted that this study was conducted with healthy young individuals, to reduce the confounding influence of insulin resistance, beta - cell dysfunction, and medications, so more research is required to know whether it will apply to people with prediabetes, type 2 diabetes and obesity.

Thus, our projects addressing beta cell function aim to reveal the underlying mechanisms of functional compensation and beta cell dysfunction to protect and recover beta cell function in diabetes therapy.

We have demonstrated that PERK / eIF2a signaling is essential for glucose - regulated insulin production by pancreatic beta cells, where defects in this pathway result in beta cell dysfunction and diabetes.

This is a huge benefit when we're trying to better understand how these cells dysfunction and ultimately die in HD.

«Because of new technologies for studying the alpha cell, promising opportunities like this effort to understand T1D's underlying alpha cell dysfunction are the first step to developing therapies to correct it.»

Fortunately though the beta cell dysfunction and the fatty liver (and T2DM) are reversible with proper diet.

The main cause of this beta cell dysfunction is the accumulation of fat inside your muscle and liver (2 — 7).

The main cause of this beta cell dysfunction is the

As you can see in the graph «Beta Cell Dysfunction», the amount of insulin produced initially goes up and up, and then starts to drop.

Disruption of cell communication can be caused by a variety of factors, including inflammation, excessive amounts of fat cells, leptin receptor issues, and beta cell dysfunction.

Noting that we are exposed to 100,000 chemicals on a daily basis, Dr. Dekel adds that many are «thyroid toxic» — leading to blocked receptor sites, cell dysfunction and poor energy generation.