Sentences with phrase «lung cancer cells»

Cell recycling (shown in green) is elevated in lung cancer cells treated with an established cancer drug.

They showed that it slowed the growth of human lung cancer cells but not kidney cancer cells in these mice.

These inhibitors act to specifically destroy abnormal lung cancer cells.

This work showed that the drug was effective in lung cancer cells.

42) Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

MicroRNA -140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2.

In this study, human lung cancer cells with additional copies of the opioid receptor grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.

Activation of beta - arrestin - 1 causes lung cancer cells to produce proteins associated with increased motility and invasion.

Mouse studies then confirmed that using the diuretic alongside the cancer drug erlotinib reversed resistance to the drug, and enabled it to kill lung cancer cells.

A collaborative team of researchers at Moffitt Cancer Center recently discovered a novel mechanism that lung cancer cells use to block detection by a type of immune cell called a natural killer cell (NK cell).

ab9484 staining GAPDH in A549 lung cancer cells by Flow Cytometry.

While some research has been done on using apoferritin for drug delivery, this is the first time it was used to target lung cancer cells.

For example, the body has the ability to suppress production of tumors from lung cancer cells if a certain genetically determined suppressor gene is available.

Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Additionally, blocking beta - arrestin - 1 in lung cancer cells prevented their growth and metastasis in mice.

«These occult lung cancer cells have found a unique way to co-opt the «brain microenvironment» and survive,» said Nguyen.

Soon after lung cancer cells (in green) spread into the brain, extracellular matrix molecules (in red) can shield them from the hostile surroundings.

This is a microscope image of lung cancer cells infected with H1N1 influenza virus.

Marcus and former graduate student Jessica Konen, PhD began by observing how a mass of lung cancer cells behaves when embedded in a 3 - D protein gel.

It is only present at low levels in lung cancer cells which are not metastatic and remain within the lung.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

Researchers from the University of Portsmouth's Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

Lung cancer cells making up an invasive pack have specialized roles as leaders and followers, which depend on each other for mobility and survival, the scientists report in Nature Communications.

«Invasive lung cancer cells display symbiosis: Key to metastasis: Leader cells pull along supportive followers.»

Experiments on human lung cancer cells confirmed the results.

In tests on EGFR - dependent lung cancer cell lines, Tan and colleagues show that the drugs gefitinib and bosutinib «showed additive and synergistic effects.»

«When we treated lung cancer cells with the antifungal drug, we saw the antiviral protection from IFITM3 pretty much disappear,» explained Christopher Chin, co-first author, also from UMMS.

The molecule, RK - 33, interrupts the cell cycle of lung cancer cells without harming normal cells, and it is effective both on its own and in combination with radiation therapy.

The preferential toxicity of the inactivation of BRG1 in MAX - deficient lung cancer cells opens novel therapeutic possibilities for the treatment of SCLC patients with MAX - deficient tumors.

Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

The researchers also showed that Timp - 1, a gene involved in regulating cell growth, carries orders from NF - KB to tell lung cancer cells to proliferate.

In a recent study, Dr. Chen showed how invaded breast and lung cancer cells manipulate protective cells in our brains to facilitate metastasis.

The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer cell types, including human and mouse lung cancer cells and human brain cancer cells, some of which were previously shown to be particularly reliant on cellular recycling.

Lastly, by screening libraries of chemical compounds across lung cancer cells, we aim to characterize novel inhibitors of these identified genes and their corresponding pathways that show promise for use as targeted therapies.

One study presented in the journal — from a group led by Patrick Singleton, PhD, assistant professor of medicine at the University of Chicago Medicine — shows how opioids already present in the body can enhance the malignant tendencies of human lung cancer cells transplanted into mice, even without the addition of morphine.

In the interim, Allen had been quietly amassing a body of research of his own on how the protein may affect lung cancer cells.

First up was Peter Campbell from Wellcome Trust Sanger Institute, who presented their first cancer genome — a small lung cancer cell line called NCI - H209.

Lead researcher, Cancer Research UK scientist Professor Henning Walczak from the UCL Cancer Institute, said: «Igniting the fuse that causes lung cancer cells to self - destruct could pave the way to a completely new treatment approach — and leave healthy cells unharmed.

And City of Hope is a leader in personalized medicine, including clinical trials here that are finding new and more effective drug combinations to kill lung cancer cells.

They infected a non-small cell lung cancer cell line containing an activating mutation in epidermal growth factor receptor (EGFR) with the ClonTracer library and monitored population dynamics after treatment with EGFR inhibitor, erlotinib.

«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».

Scientists from Moffitt reported in the Jan. 19 online edition of Cancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arrestin - 1.

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.