Sentences with phrase «of osteoblasts»

You would basically see an increased activity of osteoblast which is your bone building cell.

The accumulation of neutrophils expressing high levels of SiglecF, compared to other neutrophils, depended on the numbers of osteoblasts in the bones.

Electron micrograph of an osteoblast cell expanding on the implant by grabbing onto the pores.

In a model of osteoblast differentiation, miR - 27 and miR - 142 were shown to regulate APC expression and to positively modulate the canonical WNT signaling pathway (Wang and Xu, 2010; Hu et al., 2013).

Panosteitis is probably a disease of the osteoblasts which, you will remember, are those bone cells that produce the organic osteoid and matrix vesicles needed for ossification.

We are using live imaging, transgenic reporters of osteoblast gene expression and targeted RNAseq approaches to identify the molecular regulators of progressive osteoblast differentiation during expansion of the skull.

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

The team led by Li and Chen generated three mouse models by deleting Cbf - beta at various stages of the osteoblast lineage.

Through this visualization method, the researchers successfully captured images of osteoblasts and osteoclasts interacting in real - time in living bone tissue.

This soluble factor was found at higher levels in the blood of animals with lung tumors, could increase the activation of osteoblasts and contributed to the maturation of neutrophils in cultured cells.

Dissolved metal ions were shown to reach the bone marrow, where they impair mesenchymal stromal cells (MSCs), the progenitors of osteoblasts, a type of cell that is responsible for bone mineralization.

The team evaluated the effects of recombinant irisin in bone cell lines, and found that irisin can directly increase the production of osteoblasts — cells that synthesize bone — and mineralization, while inhibiting the production of osteoclasts — cells that break down bone.

Clough et al. first considered responses of human mesenchymal stem cells (hMSCs) present in the BM to the GSK3β - inhibitor (2 ′ Z, 3 ′ E)-6-bromoindirubin-3 ′ - oxime (BIO) at a concentration of 800 nM, given that hMSCs represent presumptive precursors of osteoblasts.

We study how subcellular dynamics contribute to the expansion of skull bones and migration of osteoblasts.

Franziska Knopf (Weidinger, TUD)-- «Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin» (2011)

Our goal is to determine how brain growth and size might contribute to the collective cellular dynamics of osteoblasts in the skull.

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

High levels of cortisol also decrease the ability of osteoblasts to synthesize new bone and interfere with absorption of Ca2 + from the gastrointestinal tract.

Over time heavy impact work increases the activity of osteoblasts within your body which in turn leads to bigger and stronger bones — now this might not be something you've considered but when you get to middle aged, or elderly, and you fall over you might find yourself thankful for your years of pumping iron as you will likely walk away far less injured then your more sedentary friends.

Endogenous sex steroids such as estrogen and testosterone may serve as prodifferentiation agents that inhibit the malignant transformation of osteoblasts (31).

When the pH is higher or more alkaline, studies have shown there's more activity of the osteoblasts, which are bone builders.

(E and F) RANKL (E) and OPG (F) expression was detected by reverse transcription polymerase chain reaction (RT - PCR) of the osteoblast cell line 7F2 treated with conditioned medium harvested from the indicated 1833 cells.

The process takes place by means of a mechanism — unveiled in this study — that inhibits the activity of the osteoblasts, the cells that produce the bone matrix so that bones can grow during childhood and youth, and remain in good condition in adulthood.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

The reasoning goes as follows: estrogen is a sex hormone that is essential to female bone health because it promotes the activity of osteoblasts, which are cells that produce bone.

In contrast, an alkaline environment has been shown to encourage the activity of osteoblasts, which are the cells that help build bone (6).

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.