Sentences with word «ortholog»

Identification of likely orthologs of tobacco salicylic acid - binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana

Our previous studies demonstrated the capacity of both WIV1 and WIV16 to use ACE2 orthologs for cell entry and to efficiently replicate in human cells [17,18].

Briefly, all eight strains were compared against each other using blastp with an e-value threshold of 1e - 6, and then we searched for orthologs as RBH.

TCF class is a classification of human transcription factors (TFs) and their mouse orthologs based on the characteristics of their DNA - binding domains.

Their analysis revealed 104 differentially regulated genes that have known orthologs in the OA - susceptible fly D. melanogaster.

Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

Top 10 % CCGs (commonly co-expressed genes) are the genes with the highest amount of co-expressed orthologs shared between human and mouse, these genes are likely to have conserved expression between both species.

Bottom 10 % CCGs are the genes with the least amount of co-expressed orthologs shared between human and mouse, these genes are likely to have divergent expression patterns between both species.

Another identified ortholog gene that emerged from the analysis is bmp (Bone Morphogenetic Protein) which is putatively associated with cartilage and bone promotion.

ARGK - 1 functions together with another energy regulator AAK - 2 / AMPK, and the mammalian ortholog creatine kinase is elevated in S6K1 - deficient mice.

Ward N, Moreno - Hagelsieb G. Quickly finding orthologs as reciprocal best hits with BLAT, LAST, and UBLAST: How much do we miss?.

Such copied orthologs are called inparalogs and they are needed to obtain the complete evolutionary picture.

Future research will aim to describe the precise molecular mechanisms of action, as well as to generate other orthologs that boost efficacy while reducing side effects.

Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans.

For each Nasonia gene with a RBH ortholog in D. melanogaster, we assigned the immune function annotated for D. melanogaster, based on previously published lists of immune genes in Drosophila [5].

We also show that genetic knockouts of MFSD12 orthologs affect pigmentation in both zebrafish and mice.

We also considered orthologs which were outliers based on their levels of differential connectivity [71].

More 360 genetic pathologies were indeed described, from which more than 50 % correspond to ortholog pathologies observed in man.

* Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus — Teri M. Greiling — Science Translational Medicine

Serena Bielli (Dahmann, MPG)-- «Characterization of the EGFL7 / 8 ortholog during Drosophila oogenesis» (2006)

Bumble bees possess a similar detoxification system thanks to a CYP9Q3 ortholog that the team has named CYP9Q4.

Jason Heaney, Baylor College of Medicine - Modelling human disease variants in murine ortholog (s) with CRISPR / Cas9

When applicable, the RBB hits were subject to further evaluation using Ortholuge, a computational tool for generating more precised ortholog predictions (developed by the Brinkman Lab).

In the future, however, smaller Cas9 orthologs and transcription factor components could lead to an activator small enough to fit into the AAV chassis and yet still retain the ability to potently induce targeted gene expression.

Abbreviations: AL3E, after L3 ecdysis; FoxO, Forkhead Box O; FRE, FoxO - Response Element; GBP, Growth - Blocking Peptide; GFP, green fluorescent protein; IIS, insulin / insulin - like growth factor signaling; ILP, insulin - like peptide; L3, third larval instar; pAKT, phosphorylated AKT; ppl, pumpless; qPCR, quantitative PCR; Rheb, Ras homolog enriched in brain ortholog; TOR, Target of Rapamycin

Our data for defining orthologs comes from NCBI's HomoloGene database.

A new version of the InParanoid ortholog database, developed at SciLifeLab and Bioinformatics Infrastructure for Life Sciences (BILS) has been released online.

The structure of YqeH: An AtNOS1 / AtNOA1 ortholog that couples gtp hydrolysis to molecular recognition

S8), in line with its vertebrate ortholog demarcating paraxial mesoderm (11).

Wingender E, Schoeps T, Haubrock M and Dönitz J. TFClass: a classification of human transcriptionfactors and their rodent orthologs.

This gene was confirmed as the Nasonia ortholog of doublesex based on protein domains, expression pattern, sex specific splice forms, and experimental demonstration that splice forms are associated with sex in a gynandromorph producing line [18].

Second, we find that DAF - 16, the FOXO ortholog, is important for maintaining multipotency during dauer.

It contains orthologs between 273 species — 246 eukaryotes, 20 bacteria, and 7 archaea.