Sentences with phrase «cell interactions»

Work in my lab investigates signaling pathways that regulate cell - cell interactions during development of pancreatic cancer.

This work will allow the researchers to formulate specific hypotheses regarding the various cell interactions and molecules involved in these processes.

In another study published this week the group investigated influenza pH1N1 virus - host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

In January 2015, I began working as a postdoctoral fellow at LIAI studying virus - host cells interactions in animal models and human cells.

Scientists at The Wistar Institute Melanoma Research Center have made huge strides in understanding the biology that underlies this disease, from basic genetics to the study of melanoma cell interaction with the microenvironment and new concepts that describe the stem cell - like abilities of melanoma to evade treatment.

Antoni Ribas, MD, PhD, University of California, Los Angeles, «T Cell and Melanoma Cell Interactions Leading to Response with PD - 1 Blockade»

By using exquisite grafting experiments in combination with focal spatially and temporally controlled transgenesis, we have discovered the unexpected and potent «paracrine role that the CNC exerts on forebrain growth and patterning early in development and documented this mechanism at the level of cell interaction, signalling and gene expression.

In one project, she studied a-agglutinin, a cell surface protein that mediates cell interaction and mating for Saccharomyces cerevisiae — baker's yeast.

It also provides novel insight into human mesenchymal stem cell - heart cell interactions that can guide future experimental studies to understand the mechanisms underlying mesenchymal stem cell therapy for the heart.

However, because the membrane itself is often made of plastic, it can disrupt cell interactions and skew the results.

«It limits the cell - cell interactions crucial to the maturation and survival of blood cells.

Look up «lysogenic virus» and you read: «a special type of virus bacterial cell interaction maintained by a complex cellular regulatory mechanism».

CD8T and NK cell interaction results in an altered phosphorylation of multiple signaling proteins and mitochondrial Ca2 + dynamics, suggesting a cellular remodeling allowing acquisition of NK cell effector / regulatory and T cell central memory phenotypes.

Delineating breast cancer cell interactions with engineered bone microenvironments.

We will assemble leading experts to discuss basic immunology, cancer - immune cell interactions, and examine how tumor - associated inflammation can be reprogrammed for therapeutic benefit.

Thus, there is a need to identify molecules that could be targeted simultaneously in tumor and bone to disrupt the tumor cell — stromal cell interactions that drive metastasis.

Using in vitro models of bacterial: gastric epithelial cell interactions, we have shown that cag island genes are required for pro-inflammatory cytokine release and induction of apoptosis, and that these events are mediated by activation of NF - kB and / or mitogen - activated protein kinases (MAPK).

Modulation of T cell and B cell interactions with vascular endothelial cells by antibodies, complement, and platelets

Extensive testing shows that micro sizing drug - cell interactions reduces cost of experiments significantly as well as increasing productivity as it enables more experiments to be done on the same platform at the same time.

By inducing a mild electrical magnetic current into damaged cells, PEMF therapy slows or stops the release of pain and inflammatory mediators, increases blood flow of the cells, and re-establishes normal cell interaction.

After serving as a Peace Corps volunteer in the Democratic Republic of Congo, she entered the MD - PhD program at Yale University where she studied influenza virus - host cell interactions in the laboratory of Dr. Ari Helenius, receiving her PhD degree in Molecular Biophysics and Biochemistry and her MD degree in 1992.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

After moving to Berkeley, he arrived at a career crossroads in 1994, when Spyros Artavanis - Tsakonas, then at Yale, discovered and subsequently patented the human relative of the fruit fly gene notch, which plays a role in cell - to - cell interactions and could be an anti-cancer target.

Cytokines are small proteins involved in cell - to - cell interactions, whose role in triggering certain diseases is now becoming clear.

- Our results show that these antiviral drugs and their combinations are potent inhibitors of Zika virus - host cell interaction.

The researchers theorized that the transplanted cells induced changes in neighboring cells, leading to today's view of development as a series of cell - cell interactions.

«We expect to use our tweezers to manipulate biological cells and molecules at single - molecule resolution, to control drug release and to study the cell - cell interaction.

Cell - cell interactions are also important in a later stage of neuronal outgrowth when processes grow into the region of their targets.

In Science (512 December, 2003; 302: 1984 - 1988) he described the first known longitudinal signals: Wnt proteins, which are known to regulate cell - cell interactions in embryonic development.

Other forms of cell - cell interaction, on the other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 — 19].

The goal is to not only provide broadly applicable experimental tools but also help transform the way in which we think about single cells, cell - cell interactions, diseased cellular states and therapeutics so as to create a new paradigm for understanding and designing systems - level cellular behaviors in multicellular organisms.

Overall these are two profoundly different outcomes of cell - to - cell interactions, which might be important for different biological processes.

The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected humans, to investigate virus - antibody - host cell interactions and cross-subtype reactivities amongst the major subtypes of the HIV pandemic.

Some of these cytokines provide critical cell - cell interactions and promote HSC differentiation, however caution should be exercised before over interpreting these findings.

Jens - Christian Roeper (Eaton, MPG)-- «The influence of cell mechanics, cell - cell interactions and proliferation on epithelial packing» (2009)

Yu - Ping Ho (Lindemann, TUD)-- «Characterization and Manipulation of Foamy Virus Capsid - Cell Interactions» (2013)

Molecular and cell biology of retrovirus - host cell interactions — Development and application of retroviral gene transfer and drug screening systems

To replicate the cell interactions in the developing heart, the scientists developed a novel method of growing two distinct cell types together.

Compared to MEF cells, which can be maintained for only 5 — 7 days after irradiation, HFF cells as a feeder layer avoid frequent passage and allow the maintenance of established cell - cell interaction during the reprogramming process.

Live - cell analysis of virus - infected cells by fluorescence microscopy or flow cytometry represents a promising approach to investigate virus - cell interactions.

Together, our data highlight mechanical roles for proto - oncogene and tumor suppressor pathways in cell - cell interactions.

Glycosylation is among the most abundant and diverse protein posttranslational modifications, regulating important cellular processes such as protein folding and cell - cell interactions.

Researchers can derive specific regions of the brain and then put them together to create brain assembloids, or miniaturized versions of multiple brain regions to capture cell - cell interaction and develop neural circuits.