Sentences with word «cisplatin»

RNA - sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel.

Dogs have often been treated with cisplatin by injecting the fluid right into the affected body cavity (intracavitary treatment).

Moreover, use of the gel led to significantly lower levels of cisplatin in liver tissue 5 centimetres away from the cancer, and in the kidneys.

Doctors have been using the chemotherapy drug cisplatin for decades, but significant toxic side effects limit its effectiveness as a treatment.

To control hyperthyroidism in the cat To protect the kidneys in dogs receiving cisplatin chemotherapy What dogs / cats should not take this medication?

FDA on chemo beads Cisplatin beads have not been approved by the Food and Drug Administration (FDA) for use in cats.

All patients enrolled in the study were ineligible for cisplatin because of medical frailty.

Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver.

IP5 worked as well as cisplatin in reducing the volumes of the tumors, the team reports today in Cancer Research.

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

The chemotherapeutic effect of cisplatin combined with the radiosensitizing effect of gold nanoparticles resulted in enhanced synergy enabling a more effective cellular damage.

«We were involved in the development and testing of several drugs commonly used to treat the disease including cisplatin and carboplatin.

Zuo and colleagues identified multiple compounds that protected cochlear cells from cisplatin, several of which are already approved to treat other conditions.

A chemotherapeutic drug called Cisplatin along with radiation treatment is thought to be helpful in cases where the tumor is inoperable because of location.

They used this method first in 2015 to generate a UV repair map of the human genome, and in 2016 they used the XR - seq method to generate the damage and repair maps of the anticancer cisplatin drug for the entire human genome.

Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of outer hair cells (middle).

Adding cisplatin to the standard gemcitabine / nab - paclitaxel drug treatment provided a very high rate of tumor shrinkage for patients with advanced pancreatic cancer, according to the results of a pilot clinical trial conducted by the HonorHealth Research Institute and the Translational Genomics Research Institute (TGen).

«We don't propose this as a current diagnostic or prognostic tool,» Costello says, «but showing that these alterations have real effect in human tumors allows us to explore the mechanisms that tumors use to resist therapies like cisplatin.»

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin - paclitaxel therapy.

Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway.

Cisplatin regulates cell autophagy in endometrial cancer cells via the PI3K / AKT / mTOR signalling pathway.

«For example, the chemotherapeutic drug cisplatin damages DNA in a certain way.

Research Paper Yangyin Fuzheng Decoction enhances anti-tumor efficacy of cisplatin on lung cancer Dongmei Wei, Lin Wang, Yuhan Chen, Gang Yin, Mei Jiang, Rui Liu, Hong Chen, Xiyuan Sun J. Cancer 2018; 9 (9): 1568 - 1574.

MIT's new nanoparticle carries three cancer - fighting drug molecules — doxorubicin is red, the small green particles are camptothecin, and the larger green core contains cisplatin (Image: Jeremiah Johnson)

The researchers are now testing new ways to decrease these side effects, including substituting paclitaxel (Taxol), which causes fewer side effects, for the highly toxic cisplatin.

In A427 cells, PARP cleavage was detected in STAT6 DN cells at 50 μM of cisplatin compared to control cells at 100 μM, whereas in H2122, it was 250 μM versus 500 μM.

Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.

The SNP is in the gene encoding cisplatin resistance related protein 9 (CLPTM1L).

Veterinarians are now able to place tiny cisplatin - impregnated beads around the tumor site.

The limitations of the chemo beads Although cisplatin beads are often effective at preventing or slowing the cancer from coming back, they do not prevent spreading (metastasis), e.g. to the lungs.

Using chemotherapeutic drugs such as Adriomycin, Vinblastine Cisplatin, and Carboplatin has also yielded disappointing results.

Implantable cisplatin chemotherapy has been used to treat dogs with osteosarcoma with encouraging results.

The sponge is a biodegradable polymer, which slowly breaks down in the body, releasing cisplatin in very high concentrations to the tissues in the surgery site.

Only a low dose of cisplatin gets into the blood stream.

Adjunct chemotherapy regimens typically include the widely - used agent Cisplatin, which improves the effectiveness of the radiation, and helps kill cells that have left the primary radiation site.

The silver complexes proved to be as effective as cisplatin in attacking both types of cancer cells.