Sentences with phrase «glioblastoma cells»

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

Glauco Souza of Nano3D Biosciences in Houston, Texas, and his colleagues incubated human glioblastoma cells from brain tumours with iron oxide and bacteriophages — viruses that infect bacteria and can bind to, but not harm, mammalian cells.

The investigators then confirmed that these four factors and their corresponding regulatory elements — the DNA segments to which transcription factors bind — were active in from 2 to 7 percent of human glioblastoma cells, cells that also expressed a known stem cell marker.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

«By treating glioblastoma cells with decitabine, we found that we can unmask targets on the tumor cell that can be recognized by killer T cells.

We detected an apoptotic marker, cleaved Caspase3 / 7 in PAL - treated glioblastoma cells, suggesting that PAL induced apoptosis.

«The cytopathic effects of Zika infection on glioblastoma cells were observed most clearly after 48 hours.

«Digoxin could be the key molecule that activates glioblastoma cell death during Zika infection,» Catharino said.

Through the mass spectrometry analysis of Zika virus - infected glioblastoma cells, scientists also identified the presence of digoxin, a molecule which induced the death of tumoral cells of skin and breast cancer in previous experiments.

«We showed that PPF decreased glioblastoma cell expression of TROY, inhibited glioma cell invasion, and made brain cancer cells more vulnerable to TMZ and radiation,» said Dr. Nhan Tran, Associate Professor and head of TGen's Central Nervous System Tumor Research Lab.

To identify the main compounds (metabolites) produced by glioblastoma cells during infection by Zika, the researchers analyzed the cells using matrix - assisted laser desorption / ionization mass spectrometry imaging (MALDI - MSI).

They also showed that inhibiting the action of an important regulatory protein complex that involves a known target gene of one of the core transcription factors — a gene active in stem - like glioblastoma cells but not differentiated cells — caused glioblastoma stem cells to lose their stem - like properties and die.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

«We also learned that PRMT5 inhibition induced the death of glioblastoma cells whether the P53 gene was mutated or not.

According to his unpublished findings, when he puts glioblastoma cells from patients into lab dishes with brain organoids, the cells attach to the surface of the organoids, burrow into them, and within 24 to 48 hours grow into a mass that eventually «looks exactly like what happened in the patient's own brain,» Fine said.

Plus, invasive glioblastoma cells show resistance to TMZ, resulting in the cancer's eventual return and the patient's death, often within a year.

To do this, they infected human malignant glioblastoma cells with Zika and recorded microscope images of them 24 hours and 48 hours after infection in order to observe any metabolic alterations (cytopathic effects) caused by inoculation of the virus.

The virus also infected full - blown glioblastoma cells but at a lower rate, and didn't infect normal brain tissues.

«Zika virus, which has become a threat to health in the Americas, could be genetically modified to destroy glioblastoma cells,» said Rodrigo Ramos Catharino, a professor at FCF - UNICAMP and head of the institution's Innovare Biomarker Laboratory.

Half to 90 percent of glioblastoma cells use this cellular process so indoximod helps a patient's own immune system to find and attack their tumors.

Glioblastoma cells do not naturally produce NY - ESO - 1, so the drug decitabine is given prior to injecting the NY - ESO - 1 targeting T cells in order to cause the tumor cells to express the NY - ESO - 1 target.

High concentrations of progesterone kill glioblastoma cells and inhibit tumor growth when the tumors are implanted in mice, researchers have found.

But itâ $ ™ s difficult not to think in terms of purpose or intent when looking at what cancers do. For example, Winship Cancer Institute scientists Abdessamad (Samad) Zerrouqi, Beata Pyrzynska, Dan Brat and Erwin Van Meir have a recent paper in Cancer Research examining how glioblastoma cells regulate the process of blood clotting.

For a positive control, nuclear extracts were prepared from a rat C6 glioblastoma cell line incubated in the presence of CoCl2 for 2 h. CoCl2 is known to increase HIF - 1α protein levels [55].

Suppression of the proliferation of human U-87 MG glioblastoma cells by new antagonists of growth hormonereleasing hormone in vivo and in vitro.

Because digoxin and other cardiac glycosides have been shown to induce cancer cell death, the researchers concluded that infection by Zika triggered synthesis of the molecule in glioblastoma cells and that this phenomenon is probably one of the factors that lead to neuronal cell death.

Prabhu and colleagues conducted a gene expression analysis of colorectal, prostate cancer and glioblastoma cell lines and patient - derived tissues that were both treated with ONC201.

A molecule on glioblastoma cells that could be used as a target for genetically engineered immune cells has been identified.

In light of these findings, the researchers at FCF - UNICAMP set out to investigate the effects of Zika virus when it infects glioblastoma cells.

Glioblastoma cells with «unmethylated» MGMT tend to be less responsive to chemotherapy and radiation than those that are «methylated.»

An initial library of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into human glioblastoma cells that were genetically engineered to make green fluorescent protein (GFP).

«We showed that Zika virus can kill the kind of glioblastoma cells that tend to be resistant to current treatments and lead to death,» said Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine at Washington University School of Medicine and the study's co-senior author.

Earlier this July, researchers from the University of Pennsylvania published data on T - cells modified to target EGFRvIII, a growth factor often present in glioblastoma cells.

Protein expression in these glioblastoma cells more closely mimicked that in real cancer cells than in 2D cultures of cells, indicating that this method could be used to study cancer (Nature Nanotechnology, DOI: 10.1038 / nnano.2010.23).

No wonder what biologists learned from their glioblastoma cell cultures and glioblastoma mice was mostly irrelevant to glioblastomas in actual patients.

The results of the analysis showed that the glioblastoma cells displayed moderate cytopathic effects 24 hours after infection, such as rounded, swollen cell bodies and formation of syncytia, masses of cytoplasm in which the membrane contains several nuclei.

The team's next steps are to test coibamide A in a mouse model for triple negative breast cancer and in a mouse model for brain cancer in which the glioblastoma cells are grown in the brain instead of the flank.

Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated cell of origin.

To determine how the cell of origin affected the characteristics of glioblastoma cells, the researchers analysed how the activity of a large number of genes differed between tumors with different origins.

«We show that the cell of origin is important for the malignancy and drug sensitivity of glioblastoma cells, and that the findings can also be applied to glioblastoma cells from patients.

«The lymphocytes will seek out and find the glioblastoma cells in the brain,» said Prins, associate professor in the departments of neurosurgery and molecular and medical pharmacology.

Take away the gene and glioblastoma cells activate the clotting process more.

His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated.