Sentences with word «glioma»
A glioma is a type of brain tumor that forms in the glial cells, which are cells that provide support and protection to the nerve cells in the brain. Full definition
Circulating levels of matrix metalloproteinases (MMP) 2 and 9 were correlated to high response rate and prolonged survival in high - grade glioma treated with bevacizumab.
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«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»
Nakano says UAB will be the only site in the Deep South for this unique trial aimed at a molecular target in glioma stem cells, a target that is different from the ones described in the Cancer Research paper.
«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.
Diffuse intrinsic pontine gliomas account for 10 percent of all childhood central nervous system tumors.
«This research is highly significant as it implies that a commercially available drug, amphotericin B, which has never been used before for patients with gliomas, may be a novel treatment to consider in future trials of patients with this frequently lethal cancer,» says Dr. Rutka.
We don't know at which point during the fifty years of culturing the mix - up occurred but we have been able to show that the ATCC U87MG line is most likely from a human glioma tumor», says Bengt Westermark.
Nakano says his study of the role of GSCs in GBM is just one approach to treat glioma tumors.
St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high - grade glioma brain tumors; particularly youngest patients
Clinical trials employing mebendazole for the treatment of high - grade glioma patients which receive temozolomide and for recurrent / progressive pediatric brain tumors are in the recruiting phase.
They currently have a trial under way at the U-M Health System which tests a two - part gene therapy approach in patients with brain tumors called gliomas in an effort to get the immune system to attack the tumor.
The Value of Diffusion Tensor Imaging in Differentiating High - Grade Gliomas from Brain Metastases: A Systematic Review and Meta - Analysis
I transitioned into neurochemistry and currently work on ethyl - mercury neurotoxicity and novel strategies for treating glioma and other cancers.
They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.
Treatment of malignant glioma using gene transfer modalities typically consists of surgical debulking of the tumor mass followed by the administration of the viral vectors into the brain tissue surrounding the tumor cavity.
Also, it is currently in clinical trials in combination with other chemotherapeutic agents for the prevention of growth and metastasis of a number of cancers including glioma [121], acute myeloid leukemia (AML)[122], chronic lymphocytic leukemia (CLL)[123].
Finding funding for in - depth epidemiological studies of kidney cancer can be difficult, however, because the disease is not as common as other cancers, and not as deadly as gliomas, or liver or pancreatic cancer.
To assess in a preliminary fashion the potential benefit of AdhCMV - TK and Ad - hCMV - Flt3L treatment of primary malignant gliomas by assessing overall survival (OS) at 12 and 24 months.
Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.
In collaboration with colleagues in the United States, Lene Uhrbom's research group has studied glioma development in mice.
«Attractive drug candidate identified to target glioma brain tumors.»
This is important for the basic understanding of how these tumors are formed and can contribute to the development of more efficient and specific glioma therapies.
On their surface, the liposomes are studded with proteins that target receptors on glioma cells.
Canine Brain Tumor Treatment and Brain Tumor MRI Research Program PVM Neurology Research Purdue Comparative Oncology Program Canine Glioma Surgery
They also investigated a new strategy to significantly inhibit glioma growth by rationally combining gemcitabine and MK - 8776, a cell cycle checkpoint inhibitor.
Unlike many other types of cancerous tumors, low - grade pediatric gliomas appear to have few genetic mutations, leaving the biology of these cancers a mystery, says Rodriguez.
«The treatment with gemcitabine and MK - 8776 to inhibit glioma growth is a promising strategy that warrants further investigation,» said Khan.
Global gene expression analyses reveal changes in biological processes after hyperthermia in a rat glioma model.
In addition, vitamin D induces glioma (a type of tumor) cell death, making the hormone of potential interest in the management of brain tumors.
«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.
A collaborative effort between Duke Medicine researchers and neurosurgeons and scientists in China has produced new genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma.
The study — Genomic profiles of low - grade murine gliomas evolve during progression to glioblastoma — published April 7, shows how these tumors continue to rapidly evolve, becoming ever more genetically diverse, as they become malignant and progress.
Researchers studying the brain tumor type glioma often use a cell line called U87MG that was established at Uppsala University almost fifty years ago.
They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.
Monje first became interested in neurons» role supporting tumors while working on childhood glioma, a cancer that strikes in the precursors to glial cells in the developing brain.
«There is strong evidence that the extent of tumour removal affects prognosis for all grades of invasive gliomas.»
Brain Tumor, Pediatric High Grade Gliomas, Histones, Epigenome, Cancer Genomics, Giant Cell Tumors of the Bone, Animal Models
Wang X, Gu X, Fan J, Wang S, Zhao F, Hof PR, Liu P, Gao Z. Recovery of empathetic function following resection of insular gliomas.
To overcome this deadly limitation, Penn State researchers created «smart fat cells» called liposomes that can pass the blood - brain barrier in mice, seek out tiny cancerous gliomas like heat - seeking missiles and light them up on an MRI.
There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation.
Reber, F., Reber, U. and Funk, R.H. Intracellular changes in astrocytes and NG 108 - 15 neuroblastoma X glioma cells induced by advanced glycation end products.