Sentences with word «immunopathology»

Finally, a number of other studies of vaccines in animal model systems have been reported but presence or absence of immunopathology after challenge was not reported.

Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.

A summary of the SARS - CoV vaccine evaluations in animal models (including the current report) that indicated an evaluation for immunopathology after challenge is presented in Table 2.

Systemic perspectives on the organism and organ level address fundamental questions of infection biology and shall contribute to reveal the molecular underpinnings of virus - induced immunopathologies and other inflammatory diseases.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

«We hope this study puts ADA in the spotlight as a powerful immune modulator in vaccine strategies enhancing anti-HIV immune responses and limiting the need for life - lasting treatments,» said Núria Climent, Ph.D., a researcher involved in the work from the Retrovirology and Viral Immunopathology Laboratory, at AIDS Research Group from IDIBAPS in Barcelona, Spain.

The Histopathology / Immunopathology Laboratory provides diagnostic and research services to the college and the Veterinary Medical Teaching Hospital as well as other Texas A&M University System resources.

The review explains that severe sepsis and persistent critical illness (PCI), which result in organ dysfunction that lasts for weeks or months, are not immunopathologies as previously thought.

Sitia G. Platelets promote liver immunopathology contributing to HBV mediated hepatocarcinogenesis.

Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV).

The concern for an occurrence of lung immunopathology on challenge of mice vaccinated with an inactivated virus vaccine, as reported by Haagmans, et al. for ferrets and nonhuman primates, was seen by us after challenge of mice vaccinated with a SARS VLP vaccine [20].

Reports of Lyme Nephritis without any organisms found on renal biopsies suggests that significant immunopathology results from the antigen as it engages with the immune system and the disease is just as easily caused by the vaccine as it is from repeated exposure to natural infection.

Veterinary Immunology Immunopathology 16: 277 - 282, 1987

Another study using the GDVII strain of TMEV to see whether resveratrol could suppress neurodegeneration caused by direct viral infection, not by immunopathology, found that resveratrol had no neuroprotective activity against the virus.

In 1980 he joined the Department of Pathology, University of Zurich, as an associate professor where, together with Hans Hengartner, he has been studying immune protection and immunopathology caused by virus infections.

This was associated with a stronger immune response and stronger immunopathology.

Having discovered the crucial role of IL - 27 in regulating immunopathology, the researchers wondered whether this could be exploited for therapeutic purposes.

They found that IL - 27 levels in infected lungs follow, with some delay, the level of virus: they peak as viral levels are starting to decline and come down when immunopathology has resolved.

However, challenge of mice given any of the vaccines led to occurrence of Th2 - type immunopathology suggesting hypersensitivity to SARS - CoV components was induced.

We thus hypothesized that increases in TNF - α production by memory CD8 T cells could be an IFN - γ — independent mediator of HLH immunopathology during immunization - enhanced HLH.

Prf1 − / − mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization.

At Duke he also served as Director of the Duke - VAMC Immunogenetics - Transplantation Laboratory, Director of the Duke Immunopathology Lab, and chief of the Renal and Transplant Pathology services.

Kontoyiannis D., Pasparakis M., Pizarro T. T., Cominelli F., Kollias G., 1999, «Impaired on / off regulation of TNF biosynthesis in mice lacking TNF AU - rich elements: implications for joint and gut - associated immunopathologies», Immunity, 10, 387 - 398 (view article).

IL -10-deficient mice mount exaggerated immune responses, which can cause severe or even lethal immunopathology.

In bacterial vaccines, the antigen causes the same immunopathology as the disease itself.

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

«Our proposed studies may lead to developing novel, non-antibiotic therapeutic strategies to control immunopathology, reduce mucus overproduction, improve hearing loss and enhance host defense for otitis media.»

Dr. Lohman - Payne's area of research is viral immunopathology, with special interest in the impact of HIV exposure in...

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

Vet Immunology Immunopathology.

Those challenged animals exhibited infection similar to unvaccinated animals as well as Th2 - type immunopathology.

A study published on May 8th in PLOS Pathogens demonstrates the importance of IL - 27 for the control of immunopathology — damage to the lung tissue caused by the immune system — and the therapeutic potential of well - timed IL - 27 application to treat life - threatening inflammation during lung infection.

Fahmy, who worked as a chemical engineer at DuPont for 5 years before doing a Ph.D. in immunopathology, had just explained the complex relationship between the lymphatic system and the circulatory system when a reporter interrupted him.

It was a rich and rewarding workplace for a novice, surrounded by people who were experts in disparate aspects of tuberculosis research including clinical trials, epidemiology, and immunopathology.

Immunopathology is a branch of medicine that deals with immune responses associated with disease.

Thus, all four vaccines evaluated induced the immunopathology; however, all four also induced neutralizing antibody and protection against infection when compared to control challenged animals.