Sentences with word «macromolecular»

Single - particle cryoelectron microscopy (cryoEM) is now able to provide structures of macromolecular assemblies to resolutions approaching 3 Å, sufficient to allow the polypeptide chain fold to be traced in a number of cases.

As an introduction to electron microscopy I can highly recommend Transmission Electron Microscopy by Ludwig Reimer and Helmut Kohl and Three - Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State by Joachim Frank.

(Collaborative Computational Project, Number 4) a collection of programs and associated data and software libraries used for macromolecular structure determination by X-ray crystallography.

Structural Biology Group The group consists of two laboratories focused on the use of macromolecular crystallography (Barry Stoddard and Roland Strong) to determine the three - dimensional structures of biological macromolecules.

The research of the department focuses on the development of cryo - electron tomography which is widely seen now as a method of unique potential for visualizing macromolecular complexes in their functional cellular context.

The pair are corresponding authors on a paper appearing online on Feb 2 in the journal Small titled «Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves.»

Epps, who is the Thomas and Kipp Gutshall Professor of Chemical and Biomolecular Engineering and professor of Materials Science and Engineering at UD, and two of his graduate students, Melody Morris and Thomas Gartner, recently published an article highlighting this work in Macromolecular Chemistry and Physics.

«Silicon nanosheets are particularly interesting because today's information technology builds on silicon and, unlike with graphene, the basic material does not need to be exchanged,» explains Tobias Helbich from the WACKER Chair for Macromolecular Chemistry at TUM.

A) To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses;

His research focuses on the development of high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein, telomerase, and Cas9.

Now Monod shows that the machinery by which the cell (Or at least the non-primitive cell, which is the only one we know) translates the codes «consists of at least fifty macromolecular components which are themselves coded in DNA.»

Blu - Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines.

Vertrees was first introduced to PyMOL in 2005 as a graduate student in biophysics at the University of Texas Medical Branch at Galveston during a class on macromolecular modeling.

Test cases showed that the need for manual corrections during refinement of macromolecular crystal structures is reduced.

Robots built from the material, which is described in a new paper in the journal Macromolecular Materials and Engineering, could also be used in search - and - rescue operations to squeeze through rubble looking for survivors, Hosoi says.

«However, I am supportive of any attempt to reverify the role of macromolecular synthesis observed immediately after the encoding of memory.»

These prestigious awards will recognize advanced graduate students and postdocs pursuing the development of software infrastructure, middleware, and frameworks that will benefit the broader field of computational molecular sciences, including biomolecular and macromolecular simulation, quantum chemistry, and materials science.

Taking the cell as a point of reference, the maintenance is directed inwards to counteract macromolecular damage.

He worked on over 12 contract and research formulation development projects characterizing different macromolecular systems and biotherapeutics, using state of the art analytical biophysical instrumentation.

Her undergraduate, graduate studies, and research focused on macromolecular chemistry, environmental technology, and toxicology.

Their findings are reported in a paper, «Size Evolution of Highly Amphiphilic Macromolecular Solution Assemblies Via a Distinct Bimodal Pathway,» published in Nature Communications on April 7.

Pavel Afonine, a Berkeley Lab computational research scientist and paper co-author, took the lead in developing the algorithm using Phenix, a software suite used traditionally in X-ray crystallography for determining macromolecular structures.

Robinson - Mosher could've worked for Pixar, Silver says, but he now uses his simulation skills to understand macromolecular interactions, research that could help scientists engineer novel proteins for drugs.

The work got her interested in motor proteins, which led her to the University of California at San Francisco for a post-doc in the lab of Ronald Vale, who studies macromolecular machines that act on the cytoskeleton.

Prof. Cecilia Clementi's research focuses on the development and applications of theoretical and computational approaches to the characterization of macromolecular dynamics.

The structural analysis guides further mutagenesis and biochemical experiments in both reconstituted systems in vitro and in primary cells, to finely analyze the mechanisms that mediate macromolecular function, or lead to a pathological dysfunction.

Not only did he lift three trophies with Roma's Primavera squad, but he's also a member of the Department of Biochemistry at the University of Cambridge specializing in macromolecular mechanisms of genome duplication and stability.

Ameer's lab is now developing an improved second - generation biomaterial with greater strength, degradation control, and macromolecular regulation.

This meant leaving protein synthesis aside for a while, instead working on viruses and macromolecular immune complexes.

Shieh is currently leading the International Institute of Macromolecular Analysis and Nanomedicine Innovation (IMANI), which is focused on translating molecular discoveries to the clinic.

«The specific macromolecular complex investigated in this study has therapeutic implications not only for addiction, but also for Parkinson's disease and schizophrenia,» said Dr. Sergi Ferré, who led the team of scientists.

«Study changes long - held concepts of cell decoding: Scientists discover macromolecular complexes that could enable medication development.»

Unlike the particles in a coffee drop, the liquid crystal drop they studied was a solution of Sunset Yellow molecules that spontaneously combine to form rod - like macromolecular assemblies, similar to how rod - like molecules order to form the liquid crystals used in LCDs.

The NIDA scientists conclude that GPCRs form part of very elaborate pre-coupled macromolecular complexes.

Ultimately, the strategy offers facile access to a unique macromolecular scaffold that may be used to meet the increasing demand of new applications for commercial polymers.

Enzymes are macromolecular biological catalysists that lead most of chemical reactions in living organisms.

However, subsequent studies of both the carbonate structures and tiny nuggets of macromolecular carbon (MMC) in the meteorite cast doubt on the claims.

The work is based in the Rosetta macromolecular modeling package developed by Baker and his colleagues.

A team of researchers led by the Department of Energy's Oak Ridge National Laboratory used neutron macromolecular crystallography to investigate the different states of three glaucoma drugs as they interact with the targeted enzyme, human carbonic anhydrase II (hCA II).

«If this is to be any serious use, I suspect it will be in collaboration with existing super-resolution techniques, on small macromolecular complexes, to push the boundaries a bit further, rather than looking at whole cells.»

Molecular dynamics was used to refine macromolecular structures by incorporating the difference between the observed crystallographic structure factor amplitude and that calculated from an assumed atomic model into the total energy of the system.

This process takes place inside veritable macromolecular machines known as ribosomes, and starts by transcribing genetic information from a cell's DNA into transportable units known as messenger RNAs (mRNAs).

«The significance of this study is that we're going to see more comparative studies of macromolecular concentrations — such as differences in proteins and lipids — which reveal things that can't be read out directly» from the genome, says Todd Preuss, a neuroscientist at Emory University who specializes in the evolution of the human brain and who was not involved in the study.

Funding: NMP is supported by «Metrology on a Cellular and Macromolecular Scale for Regenerative Medicine» - Metregen (2009 — 2012), supporting theoretical research for scaffold design.

One needs no oracle to predict that this will eventually be the fate of many, if not most, macromolecular crystallographers.