Sentences with phrase «of gene activity»

His team is now looking at patterns of gene activity in the four brains to work out whether it is possible to detect early signs associated with conditions like autism.

Some human body tissues show greater levels of gene activity shortly after death than others, a new study finds.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

It turns out that surprisingly low doses can be potent regulators of gene activity, while high doses simply shut activity down.

Among their findings, the researchers provided evidence for a new potential form of interaction between chromosomes that contributes to the control of gene activity.

Two of the mouse's genes had been altered so that the egg had a pattern of gene activity similar to that of a sperm.

This gives a very detailed map of gene activity, down to the level of individual cells.

With a cell - by - cell assessment of gene activity they are monitoring how precursor cells shape and organize themselves into something loosely resembling a functioning liver.

The bulk of a cell's DNA is contained in its nucleus, as well as enough RNA for analyses of gene activity.

We took a second muscle biopsy to see what happened to their individual gene expression profile, which is a genetic portrait of gene activity.

He argues that establishing relationships of gene activity with such conditions should be a primary objective of the data analysis - and that statistical programs must allow for this.

The muscles of the mice receiving both the drug and the training also showed evidence of new patterns of gene activity not seen in mice taking the drug alone or exercise training alone.

Typically, cells of the same type have matching patterns of gene activity — many of the same genes are turned off or on in all cells.

To understand the evolutionary basis for this interlude, Griffith recently led a study of gene activity in a marsupial, the gray short - tailed opossum (Monodelphis domestica).

A study of gene activity in the brains of people who suffered from depression reveals that their daily clocks were probably out of whack.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

«Put simply, RNA - seq takes a snapshot of the gene activity of the cell.

One CUMC team, led by Tom Maniatis, PhD, the Isidore S. Edelman Professor and chair of biochemistry & molecular biophysics, will construct an atlas of gene activity of all cells in the human spinal cord.

«Role for enhancers in bursts of gene activity.»

Several years ago, NCI scientists identified the two primary subtypes of DLBCL based on characteristic patterns of gene activity within the lymphoma cells.

The deletions made it difficult for certain proteins to land, resulting in only a brief window of gene activity during the development of the python embryo, Cohn and Leal report today in Current Biology.

It's not as simple as turning a gene on or off, Zhu noted; instead, a treatment must prompt the right amount of gene activity, and that may require prodding a gene to do more or pulling on the reins so that it does less.

The main advantage of using single - cell RNA - Seq technology is it provides a blueprint of gene activity in each and every cell type.

These sequences in our DNA are often situated far away from the actual genes they regulate, in comparison to so called promoter regions, which traditionally have been considered to control most of the gene activity.

In their comprehensive study, which involved a search of gene activity maps as well as testing of human brain tissue, the researchers identified more than 100 enhancers which were much more active in the brain than in other tissues.

But new U-M led research shows that the clock may be broken in the brains of people with depression — even at the level of the gene activity inside their brain cells.

As the level of gene activity knockdown associated with transgenic RNAi depends on the level of expression of the hairpin constructs, we generated a number of derivatives of our initial vector, called the «VALIUM» series, to improve the efficiency of the method.

The development of an embryo, for example, looks like a well - programmed process, orchestrated by predictable waves of gene activity to produce a specific pattern of tissues.

Noise has traditionally been difficult to study in biology, because most biological techniques, such as measurement of gene activity, average the output of many cells, erasing individual variability.

Singh's laboratory had become interested in studying the role of nuclear postioning in the control of gene activity based on work analyzing immunoglobulin heavy - chain genes.

To the scientists, these findings collectively suggest that changes in chromatin leads to cascades of gene activity that drive fly development.

However, using an innovative method for the identification of factors capable of binding to and «reading» the chemical tags that characterize unconventional DNA bases, Carell and colleagues have shown that stem cells contain specific proteins that recognize hydroxymethyluracil, and could therefore contribute to the regulation of gene activity in these cells.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

Based on studies of gene activity and immune cells, he found that these mammals have «domesticated» implantation's inflammatory response.

Scientists at the Centre for Genomic Regulation (CRG) in Barcelona, Spain, have developed a new technique to crack the underlying DNA code for the «control dials» that determine levels of gene activity in bacteria.

The alteration of gene activity, called epigenetics, might result from modification of RNA molecules that interact with genes; a modification of the packaging that carries DNA; molecular switches attached directly to the DNA itself; or even something to do with the cell's power - stations, the mitochondria, Baugh said.

RNA - seq is a leading technology for producing these snapshots of gene activity.

The findings may even have implications for studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells.

A second project, taking about a year to complete at a cost of $ 2 million, will make an atlas of gene activity in the mouse spinal cord.

A new study by researchers at Princeton University suggests that sporadic bursts of gene activity may be important features of genetic regulation rather than just occasional mishaps.

Because yeast and other fungi, like humans, are eukaryotes, organisms with a compartmentalized cellular structure and complex mechanisms for control of their gene activity, study of yeast genome function is also a key component of biomedical research.

Also, the metabolic markers and levels of gene activity in Poldrack's blood varied considerably with diet and brain function, as well as the severity of his psoriasis, an autoimmune disease that causes his scalp to flake.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Much higher levels of gene activity were triggered in these experiments than scientists have achieved before, says Michael Hemann, a cancer biologist at MIT.

Publishing their findings in the open - access journal Nature Communications, the researchers discovered DNA sequences for «control dials» that consistently produce very high levels of gene activity.

Studies of gene activity have now revealed that many lichens are instead a threesome, with two fungi in the mix.

However, all regions of the human brain have molecular signatures very similar to those of our primate relatives, yet some regions contain distinctly human patterns of gene activity that mark the brain's evolution and may contribute to our cognitive abilities, a new Yale - led study has found.

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

When the researchers looked at the patterns of gene activity in the embryos, they found that the cell death was linked to the switching on of a gene called Bmp4.