Sentences with phrase «regulation of gene expression»

This interaction is thought to be important in regulation of gene expression.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

It is an important factor for the correct regulation of gene expression within all these groups of organisms.

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Protein complexes, epigenetic regulation of gene expression and cancer.

His thesis was entitled «Regulation of gene expression by the ubiquitin - proteasome system.»

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

Exposing S. pistillata to seawater with an elevated calcium concentration resulted in up - regulation of gene expression during the day relative to the night.

The work described here has established the framework for the future systematic characterization of the global program and molecular mechanisms of post-transcriptional regulation of gene expression in any genetically tractable organism.

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers.

The newly identified variation is found in the region of IFITM3 involved in regulation of gene expression through the binding of proteins and other chemicals that promote or suppress gene activity.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

«Novel regulation of gene expression in brain tumors identified.»

The Lazar lab has been working on HDAC3 for over a decade, focusing on the pivotal role of this enzyme in hormone - mediated regulation of gene expression and metabolism.

Embryonic development is a well - studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner.

In this review article, we highlight transcriptional regulation of gene expression in response to drought.»

During a segment on Yamanaka's research, one of these animations is particularly useful in explaining how chromatin regulation of gene expression is different in different types of tissues.

Finally, Yingjie Guan, assistant professor (research) of orthopaedics at Brown and Lifespan, at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.

Abundant RNA - binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Research Interests: RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

This last observation seems to indicate that promoter methylation does not play a significant role in regulation of gene expression between tissues.

«Gene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Karpen.

Since SP1 is an activator of transcription [45], the deletion of an SP1 site should result in down regulation of gene expression.

The fact that a large number of genes are responsive to the effects of TSA and L - methionine implies that the epigenetic regulation of gene expression as a function of maternal care may be extensive.

As RNA - binding proteins are still systematically understudied, we will provide important insights of the roles of a key player in post-transcriptional regulation of gene expression.

A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess from the University of Freiburg have now identified an enzyme, a special pair of RNA scissors, which is involved in CRISPR / Cas systems and the correct regulation of gene expression - in other words, in reading genes and translating their information into proteins.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

Following this in 2015, an article (Alsaweed et al.) described over 300 novel milk microRNA molecules, components that are known to play a key role in the regulation of gene expression.

Sankar Ghosh, professor of immunobiology at Yale University, explores the regulation of gene expression in developing and differentiating lymphocytes.

«The reversible nature of the m6A methylmark adds a new layer to the regulation of gene expression now termed «epitranscriptomics» and warrants further research to establish links with human disease such as cancer,» adds Dr Irmgard Haussmann of Coventry University.

This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

It involves detecting micro-RNAs (miRNAs): small, non-coding RNA molecules that are important in the regulation of gene expression.

VlincRNAs may contribute to the regulation of gene expression in the nucleus of the cell.

Beyond their participation in host defense, increasing evidence suggests that these modifications also play important roles in the regulation of gene expression, virulence and antibiotic resistance.

Berger and Daniel Bose, PhD, a postdoctoral fellow in her lab, study the regulation of gene expression from enhancers, non-coding regions of the genome more distant from protein - coding regions.

A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

The regulation of gene expression, for example, is extremely difficult to study through the genome alone.

The regulation of gene expression far outlasts the actual seizure event that triggered it.»

«Researchers have begun to recognize that understanding non-genetic inheritance, including culture, ecology, the microbiome, and regulation of gene expression, is fundamental to fully comprehending evolution,» said Creanza.

Scientists are only beginning to unravel the complexity of this post-transcriptional regulation of gene expression.

«This is the first piece of evidence that humans may have a faster rate» of change in the regulation of gene expression, notes Caro - Beth Stewart, a molecular evolutionist at the State University of New York, Albany.

«Regarding the other histones, which are major proteins in the regulation of gene expression, we know which enzymes modify them, their functions, and how they are regulated... But for some reason, the functions of histone 1 have not been addressed,» he adds.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.

To understand and analyze the regulation of gene expression patterns, quantitative RNA sequencing is used.