Sentences with phrase «to lead to cell death»

These clumps spread from cell to cell, eventually leading to cell deaths.

The faulty gene leads to cell death in neurons in the brain resulting in gradual physical, mental and emotional changes, and ultimately death.

The opposing stretch forces cause the cell to rupture, which leads to cell death.

These defects, in turn, affect the cell's ability to generate energy and can potentially lead to cell death and are associated with aging and various neurological diseases.

Even a change in temperature of + / - 5 ° C subjects the cell to a heat shock or cold shock, which can lead to cell death after a few hours.

These strategies do not lead to cell death but maintain an environment that is conducive to bacterial proliferation.

The disruption of the cell's normal pathway usually leads to cell death.

In the long term, this damages the neurons, eventually leading to cell death.

Such undesired protein waste can be toxic for cells and may even lead to cell death.

Researchers have long suspected that inflammation in the brain leads to the cell death and brain atrophy found in people with Alzheimer's disease.

The inhibition of Rac1 also led to cell death in mouse lungs cultured in the lab.

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Brain injuries, whether caused by trauma or neurodegeneration, lead to cell death accompanied by considerable functional impairment.

If tau stops functioning, the amyloid beta accumulation leads to cell death,» explains Monica Javidnia, a pharmacology doctoral candidate at GUMC.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

Sinclair says he's not sure exactly how SIRT3 and SIRT4 beef up the mitochondria's energy output, but that events leading to cell death are at the very least delayed when there are vast quantities of the enzymes.

«This binding is lost in beta cells lacking the insulin receptor, and the loss of binding leads to cell death rather than division.»

Basically the cells are under so much stress that there main protective shield (GSH) gets worn down and oxidative stress damages the mitochondria and the DNA leading to cell death.

This is especially noteworthy because most pharmaceutical preparations used would not only eradicate MCF - 7 breast cancer cells, but also non-selectively lead to cell death of otherwise healthy cells.

The guinea pig muscles were damaged by lipid peroxidation leading to cell death.

Because the insufficiency of repair will cause the accumulation of DNA damage which leads to cell death or functional defect, it is reasonable to hypothesize that DDR and repair is closely associated with aging.

Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging.

Whereas many stores and restaurants rely on bouillon cubes and MSG to flavor their foods and products, Chuck points out that these ingredients offer very little benefit and actually pose some health risks an example of which is how MSG over stimulates glutamate receptors in the brain potentially leading to cell death.

Unable to flush out calcium, the cell may become overstimulated, damaging the cells and even leading to cell death (apoptosis).

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

A malfunction of fatty acid regulation can, however, lead to cell death and — depending on the type of cell — trigger diseases such as diabetes.»

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

The simulations revealed that the protein aggregates into ringlike structures that perforate cell membranes (the green areas in the image), leading to cell death and triggering Parkinson's.

Eventually, the buildup of misfolded proteins becomes toxic and leads to cell death.

The study also revealed that defects in the autophagy process caused accumulation of certain proteins that prompted activation of an immune response in cancer cells and led to cell death.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

«If you have an immature lung that is genetically predisposed to getting BPD, then it's getting hit with supplemental oxygen, this sets off inflammation and leads to cell death.

Vacuolating cytotoxin A (VacA) was previously the only main H. pylori factor known to act on mitochondria, causing cellular membrane and organelle dysfunction and leading to cell death.

Animal studies have shown that lengthy or multiple experiences with anesthesia can lead to cell death and problems with the formation of connections among brain cells.

SiRNA is a segment of RNA that when delivered into a cell interferes with expression of a specific mutated gene, leading to cell death.

We need more research into the basic mechanisms that lead to cell death.»

The Zika virus is known to negatively impact the growth of fetal brains and a group of researchers publishing in the journal Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferation.

Chromosomal instability (CIN) often results in aneuploidy, which compromises cell fitness and leads to cell death.

The greater presence of yellow in C, a couple days after transplantation, displays the activation of an enzyme that leads to cell death.

Both excessive acidity and alkalinity can affect your bodily functions and lead to cell death.

Ricin is a lectin isolated in the castor oil bean and it acts on certain protein cells, allowing the ricin to enter the cell and prevent protein synthesis, eventually leading to cell death.

Basically inorganic arsenic in the body can lead to cell death.

It also inhibits the growth of cultured human breast cancer cells, leading to cell death.

Oxygen free radicals are toxic for cells, since they cause damage to cell membranes surrounding living cells as well as their nucleus and other inner organelles, eventually leading to cell death.