Sentences with word «tumorigenic»

We also found that cells derived from this novel subpopulation form colonies readily, are highly tumorigenic in immune - deficient mice, and exhibit both stem - like and EMT phenotypes.

FDA's position on assessment of tumorigenic potential of cell products for regenerative medicine

Our previous work has shown that the CD44 + and CD44 + α2β1 + prostate cancer cell populations are enriched in tumorigenic and metastatic CSCs, whereas the α2β1 + prostate cancer cells most likely mark fast - proliferating tumor progenitors (28, 29).

Our lab is focused on delineating the mechanisms underlying these key GSC tumorigenic properties with a long - term goal of uncovering potential therapeutic targets.

Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells

Based on these discoveries macrophages can be amplified in culture as mature differentiated cells, without stem cell intermediates or tumorigenic transformation.

This is partly due to what he describes as «a more sophisticated view that these cancers are similar in their molecular footprint — in the pathways that have caused them to become tumorigenic.»

The prevailing theory of cancer progression — that it's driven by the accumulation of genetic mutations that increase tumorigenic «fitness» — holds true for the early stages of cancer progression, but metastases seem to find new ways to increase their fitness, McDonald said.

Cancer stem cells (CSCs) known as tumorigenic cells are biologically distinct from diverse subpopulations.

The prognostic role of a gene signature from tumorigenic breast - cancer cells.

«We were able to boost fluorescence accumulation in the highly tumorigenic low - fluorescence glioma stem cell subpopulation using a clinically approved iron chelator,» co-corresponding author Kouichi Tabu says.

Nakano and colleagues found that one form of the enzyme aldehyde dehydrogenase — ALDH1A3 — is a specific marker for mesenchymal GSCs, and his group is the first to show that, among the heterogeneous mix of cells in a GBM tumor, cells with high levels of ALDH1A3 expression were more tumorigenic in vivo than are cells that are low in ALDH1A3.

The effect was observed in multiple mammalian cell lines, including both normal and tumorigenic models.

Although we agree that greater investments are needed in the clinical development of these therapies, we disagree with the authors» suggestion that, relative to embryonic stem cells, adult stem cells provide a superior vehicle for cell - based therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.

Finally, the study suggests new tumorigenic and cellular functions of BAP1 and shows for the first time the interest of studying the proteome as readout of BAP1 inactivation.

Specifically, the Ignatius laboratory will study tumorigenic cell populations that self - renew and metastasize using a combination of zebrafish, murine xenograft and human cell culture systems.

The present results have important implications in understanding morphologic heterogeneities and tumorigenic hierarchies in human epithelial cancer cells.

The authors had previously profiled tumorigenic and non-tumorigenic human breast cancer populations and profiled their microRNA content.

As mentioned above, pancreatic cancers and Kras - driven lung cancers are highly dependent on autophagy for tumorigenic development, whereas other types of cancers might only use autophagy as a cell survival mechanism when stressed.

González - Sarrías, A.; Li, L.; Seeram, N.P. Effects of maple (Acer) plant part extracts on proliferation, apoptosis, and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells.

«Under a high - fat diet, these non-stem cells acquire the properties of stem cells so that when they are transformed they become tumorigenic,» says Whitehead Member David Sabatini, who is also an MIT professor of biology and an investigator of the Howard Hughes Medical Institute.

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»

The current research suggests that pancreatic cancer cells that spread to organs that receive a blood supply rich in glucose and other nutrients, such as the liver and lungs, acquire metabolic adaptations to use these «natural resources» to increase their tumorigenic fitness.

The team also found that ERAS, a tumorigenic gene expressed in mouse embryonic stem cells and iPSCs, was mutated and dysfunctional in the mole - rat iPSCs.

The net effect is a tumorigenic environment filled with what Ko calls inappropriate offspring.

Consequently, the use of such a marker suggests a new strategy to screen novel therapeutics in a rapid and efficient manner directly in the tumorigenic mouse.

In order to block these tumorigenic cells, novel therapeutics that modulate immune checkpoint signaling have been developed, with some already available and others in clinical trials.

In the cases of viruses with small DNA genomes, such as the tumorigenic simian virus 40 (SV40), the entire viral DNA can be inserted into the bacterial plasmid pBR322 and cloned in Escherichia coli.

The study, «Loss of miR - 203 regulates cell shape and matrix adhesion through ROBO1 / Rac / FAK in response to stiffness» by Lily Thao - Nhi Le and colleagues, identifies a signaling pathway that may protect breast cells from the tumorigenic effects of stiff extracellular matrices.

«This would indicate that fat from both mice and humans can make a non-tumorigenic cell malignantly transform into a tumorigenic cell,» Bernard said.

Researchers from Leibniz Institute for Age Research — Fritz Lipmann Institute (FLI) in Jena, Germany, have now found surprising news on the role that telomeres and telomerase play for the tumorigenic process (published in The EMBO Journal).

In SA2 - deficient Ewing sarcoma and bladder cancer, further depletion of SA1 profoundly and specifically suppressed cancer cell proliferation, survival and tumorigenic potential.

«If you could induce them to resolve that state — to differentiate into one or the other cell type — they would cease to be tumorigenic.»

Development of a bioengineered model to quantitatively measure the tumorigenic properties of cancer - associated fibroblasts in human prostate cancer.

We identified 12 transforming alleles, including two in genes (PIK3CB, POT1) that have not been shown to be tumorigenic.