Sentences with phrase «cellular stress»

This «cellular stress response» helps keep cells alive by buying them time to recover.

Their results show that both age and SD combine to induce cellular stress in the pancreas.

Daily medium exchanges help alleviate cellular stresses associated with pH changes and resource consumption due to the high cell density of the culture.

In fact, over time cellular stress and hormone imbalance can cause hypothyroidism.

of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

• Reduced Cellular Oxidation — Elevated cellular stress causes increased cellular oxidation, which translates into faster cellular aging.

Can understanding the molecular mechanisms that govern chromatin state and enhancer plasticity during cellular stress provide new insights into the pathogenesis of cardiovascular and metabolic diseases?

Though cells must make proteins to survive, protein production is a highly energy - consuming process and, for diseased cells, the process leaves too few energy reserves to deal with cellular stress or other demands.

I also make sure to get enough food and supplemental sources of glutathione and its precursors when pregnant to avoid inflammation and cellular stress as much as possible.

Consistent with a lower thermal tolerance, longfin smelt exhibited a pronounced cellular stress response after exposure to 20 °C that was not observed in delta smelt.

Some, like glucoraphanin (precursor to sulforaphane), mostly in broccoli sprouts and broccoli, are likely considerably more potent in inducing cellular stress responses (yes, that's a good thing).

Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact on health by bolster - ing adaptive cellular stress response pathways that protect against and counteract a range of major diseases.

Restoring that protection might help safeguard the brain against cellular stress that contributes to aging.

Other mice, with robust beta cells that were good at repairing DNA damage, were able to stay non-diabetic for life, even when those islets were placed under severe cellular stress.

It's a first step in mechanistically understanding how cellular stress responses are wired in specific contexts.»

«The stability of BOK appears to be directly related to the amount of cellular stress experienced within the endoplasmic reticulum.»

«Cellular stress in the brain may contribute to non-alcoholic fatty liver disease: connection between cellular stress in brain and non-alcoholic fatty liver disease.»

But what role does cellular stress play in the production of hemoglobin?

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

Known as the «guardian of the human genome,» the p53 gene recognizes cellular stress and stops cell proliferation by either allowing the cell to recover from the stress or activating a protein that induces a program to kill the cell if the damage can't be repaired.

My lab at HPU studies membrane traffic during times of cellular stress using baker's yeast as a model system.

To further characterize HPP - 4382, we screened a selection of alternative genes for expression: two markers of endoplasmic - or general cellular stress, HSPA6 and GADD45A, and ICAM1, a target of NF - B.

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

Stress can worsen symptoms of inflammatory diseases such as multiple sclerosis but the molecular mechanisms linking cellular stress signaling and neuroinflammation had remained unclear.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

The study that will be published in the March 21 issue of the science magazine Cell describes how insulin, through the activity of an enzyme recently described by the Freiburg research team, blocks one of the most important cellular stress regulators, a protein called SKN - 1.

Basically, the longer your telomeres are, the longer your life expectancy is, and studies suggest that meditation can help preserve our telomeres, which reduces cellular stress and extends life span.

When mice are genetically modified to lose Nrf2 function, they also lose many of the anti-inflammatory and antioxidant benefits of isocyothianate exposure, further linking cruciferous vegetables and Nrf2.41 Studies even suggest that Nrf2 is required to gain the beneficial effects of isocyothianates, connecting the benefits of exercise, fasting, periodic ketogenesis, and healthy cellular stresses with vegetable and spice consumption, as they all can stress our cells and engage Nrf2.42

«TIA - 1 is known for its ability to regulate gene expression during cellular stress,» says Hewett, who studies the processes that suppress the severe electrical storms in the brain, leading to seizures.

Analytical endpoints included examination... of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

Consistent with having a lower temperature tolerance, longfin smelt exhibited a pronounced cellular stress response, with an upregulation of heat shock proteins, after exposure to 20 °C that was not observed in delta smelt.

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Among berries, I mostly consume strawberries (daily morning smoothie with a cup of frozen strawberries, half banana, cup water, 3 tbsp flax seed, 2 tbsp wheat germ), as their flavonoid, fisetin, appears particularly potent in inducing cellular stress responses and crossing the blood brain barrier.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR gene's promoter (a segment of DNA near the TTR gene).

Mice with fragile beta cells that were poor at repairing DNA damage would rapidly develop diabetes when those beta cells were challenged by cellular stress.

Placentas had underdeveloped blood vessels, the barrier between mother and fetal cells was abnormal, and researchers spotted evidence of cellular stress.

Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig's disease.

In response to cellular stress that can cause cancer, the team found that LC3, chromatin, and laminB1 migrate from the nucleus — via the nuclear blebs — into the cytoplasm and are eventually targeted for disposal.

Pancreas tissue from acutely sleep - deprived aged animals exhibited a marked increase in CHOP, a protein associated with cell death, suggesting a maladaptive response to cellular stress with age that was amplified by sleep deprivation.

The team examined tissues in mice for cellular stress following acute SD, and they also looked for cellular stress in aging mice.

This, in turn, activated a cellular stress response pathway that culminated in the degradation of a protein called CtIP that is required for homologous recombination repair.

Th ey found that host RNAs generated during cellular stress could induce an RLR - dependent inflammatory response.

The team knew from previous experiments that ISRIB prevents the cellular stress response by stabilizing a protein called eIF2B, which typically helps turn on protein production.

Now scientists have a clearer view of how ISRIB works — by pinning together parts of a protein involved in cellular stress.