Sentences with word «cytotoxicity»

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

Research Paper In vitro single - strand DNA damage and cancer cell cytotoxicity effects of Temozolomide Shruti Purohit, Devashree Jahagirdar, Azad Kumar, Nilesh Kumar Sharma Oncomedicine 2017; 2: 102 - 110.

Dsg3 CAAR - T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3 - specific B cells in vivo.

Rituximab is thought to function through activation of natural killer cells, resulting in cellular cytotoxicity.

In cytotoxicity assays employing PPAM, we found no significant differences of IC50 values between SCLC tumor cells, SCLC CTC lines which express the Wnt pathway and normal cells such as HEK293 (data not shown).

They can be localized within or on cellular plasma membranes and have low cytotoxicity when interfaced with experimental brain systems.

This drug showed cytotoxicity against colon cancer cells, intestinal polyposis and lymphoma cells via JAK2 / STAT5 signaling and impairment of mitochondrial functions [58, 60, 61].

Class IV lasers can stimulate blood flow, thus increasing cytotoxicity when used in conjunction with chemotherapy on large tumors.

tuberculosis and cytotoxicity toward macrophages in a high throughput manner.

The combination of ischaemia and heat cytotoxicity can damage the intestinal lining and release gut content into the bloodstream.

T lymphocytes can recognize these new or altered antigens and are able to fight tumour through direct cytotoxicity or cytokine secretion.

Some studies have demonstrated cytotoxicity of silver in wound repair and natural antimicrobials are being sought as alternative topical wound treatments to silver.

«Over the years, we've developed the theory of «sequential cytotoxicity,» which simply means you give an initial attack on the cancer cell and then you give a second chemical attack,» Dimmock said.

Some compounds of the dozens of variations the scientists created exhibit potent cytotoxicities against certain cancer cells, including a drug - resistant cell line, Nicolaou said.

Indeed, the toxic compounds in the database, which had been characterized using high - content cytotoxicity screening, showed greater rates of fluorescence quenching.

Many products need large amounts of anti-microbial agents to maximize killing efficacy, which can weaken the mechanical properties and be toxic to tissues, but we showed that this material has outstanding mechanical properties and long - lasting antibiofilm activities without cytotoxicity.»

Invitro cytotoxicity analysis, invitro magnetic resonance imaging and optical imaging of the prepared samples were carried out.

The invitro cytotoxicity results shows that the developed contrasts are not toxic at the lower concentrations.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivo.

Similarly, antigen - specific CD4 + CD25 + regulatory T cells also suppress tumor - specific CD8 T cell cytotoxicity although this mechanism relies on TGF - β secretion by regulatory cells 196, 197.

Ortiz C, Morales L, Sastre M, Haskins WE, Matta J. Cytotoxicity and genotoxicity assessment of sandalwood essential oil in human breast cell lines MCF - 7 and MCF - 10A.

Affram K, Udofot O, Agyare E. Cytotoxicity of gemcitabine - loaded thermosensitive liposomes in pancreatic cancer cell lines.

The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].

Antitumor activity of pyrvinium pamoate, 6 -(dimethylamino)-2 -[2 -(2,5 - dimethyl -1-phenyl-1H-pyrrol-3-yl) ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation.

The guanidine derivatives 120 and 128 showed remarkable activities and the best cytotoxicity profiles within the whole series.

This characteristic together with their low cytotoxicity makes them promising candidates for future in vivo evaluation to develop non-peptide CXCR4 inhibitors.

IFN - α Augments NK - mediated Antibody - Dependent Cellular Cytotoxicity (ADCC) of HIV - 1 Infected Autologous CD4 + T Cells Regardless of MHC - I Downregulation.

A new study demonstrates that it is possible to vaccinate patients with MDS against a decitabine - induced antigen and that the level of induced expression is sufficient to trigger cytotoxicity in patient - derived vaccine - induced T cells.

They found that decreased presence of lymphatic vessels and reduced immune cytotoxicity were more strongly associated with the metastatic process than tumor - intrinsic factors such as chromosomal instability or cancer - associated mutations.

Though this exploitation of biochemical and cellular pathways, the Gelipo - TRAIL - Dox combo accumulated more than the controls in the affected tumor tissue and had a greater cytotoxicity.

Project: GPNMB Deficiency and Associated Cytotoxicity in Pigment Dispersion Syndrome, a Precursor of Pigmentary Glaucoma

MITO - ID ® Membrane Potential Cytotoxicity Kit for Microplates A Real - time Mitochondrial Membrane Potential Assay with Superior Sensitivity

Furthermore, inhibition of JNK partially rescued 15d - PGJ2 cytotoxicity.

15d - PGJ2 is a potential therapeutic agent for OS, exerting cytotoxicity mediated through both AKT and PKA - PLK1 inhibition, and these results form the basis for further analysis of its role in animal studies and clinical applications.

Trastuzumab directly inhibits the proliferation of HER2 - overexpressing breast cancer cells and induces immune - mediated killing of target cancer cells through antibody - dependent cellular cytotoxicity [20].

✓ Cytotoxicity — WGA has been demonstrated to be cytotoxic to both normal and cancerous cell lines, capable of inducing either cell cycle arrest or programmed cell death (apoptosis).

Selenium helps protect against iodine toxicity by ensuring that glutathione peroxidase activity in the thyroid is adequate to avoid cytotoxicity of hydrogen peroxide (34).

Synaptic Pharmaceutical / Lundbeck Research USA, Paramus • NJ 2002 — 2006 Research Associate Facilitated with assistance in the evaluation and implementation of one new cytotoxicity assay to support compound profiling efforts within projects.

Microbiology services include Spectrum of Antibacterial and Antifungal Activity, Biofilm Profiling, Resistance Profiling, Cytotoxicity Testing and issue Efficacy Modeling.

One of these, antibody - dependent cell - mediated cytotoxicity (ADCC), involves binding antigens on the surface of infected cells with antibodies that make them attractive to natural killer cells that can then recognize and destroy them.

Treatment of the Gb3 - expressing gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with irinotecan alone.