Sentences with phrase «decreased expression»

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

If you have been expressing for fifteen minutes, decrease expression time to ten minutes, and so forth.

This gene module consists of a collection of genes which increase or decrease expression together.

Two mutations that decrease expression of this gene were found in high frequencies in people with the darkest skin.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

By decreasing the expression of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates cell migration and metastasis.

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

McNamara, professor in the Department of Animal Sciences and (intercollegiate, multidisciplinary) Nutrition Program, and Sumner, his doctoral student and postdoctoral research associate, have demonstrated that chromium in the diet changes the metabolism of body fat in dairy cattle by stimulating the expression of certain genes while simultaneously decreasing the expression of others.

Three new independently conducted studies show that the increased BHB produced in a ketogenic diet improved the NAD + / NADH ratio which decreases expression of the pro-inflammatory NF - κB gene, resulting in:

SELECTOR DIAL: To increase / decrease the expression strength.

In addition, progesterone boosted expression of several of these genes in controls, while estrogen decreased expression in cell lines derived from PMDD patients.

They found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP - 2, which acts as a master regulator for cholesterol production.

In addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cells.

Some genetic variations in SLC16A11 simply decrease its expression in the liver (an organ that helps regulate blood sugar levels, and is therefore implicated in T2D).

We found that 180 genes showed significantly decreased expression and 40 genes showed significantly increased expression in ABL1 / ABL2 knockdown cells (fig.

The log10 FPKM +1 values from the RNAseq data are plotted in blue, and genes are ordered by decreasing expression level.

Botox is a form of muscle relaxant that decreases expression lines by paralysing muscle movement, and is mainly used on the upper face for frown, forehead and crow's feet lines.

Chronic low carb - > Hypothyroidism (low T3)- > Decreased expression of LDL receptors in the liver - > Higher serum cholesterol

Furthermore, capsaicin decreased the expression of prostate - specific antigen (PSA) and inhibited the ability of the dihydrotestosterone to activate PSA.

O - 3FA decreased expression of inflammatory genes and increased production of anti-inflammatory compounds in fatty tissue.

The study showed that the combination of NMX1000 ® avocado / soybean unsaponifiables, FCHG49 ® glucosamine hydrochloride, and TRH122 ® low molecular weight chondroitin sulfate decreased expression of the enzyme cyclooxygenase - 2 that regulates the production of the mediator prostaglandin E2 (PGE2) in both equine chondrocytes and equine osteoblasts.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are over-expressed in some cancers.

Knockdown of NANCI expression during lung development leads to decreased Nkx2.1 expression and mimics the defects due to loss of a single copy of the Nkx2.1 gene, including decreased expression of surfactant proteins.

It has been reported that human breast CSCs and normal human mammary stem / progenitor cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].

Michaelsson G, Ahs S, Hammastrom I, Pihl Lundin I, Hagforsen E. Gluten - free Diet in Psoriasis Patients with Antibodies to Gliadin Results in Decreased Expression of Tissue Transglutaminase and Fewer Ki67z Cells in the Dermis.

Flavonoids, including anthocyanins, seem to modulate this type of monocyte adhesion during the inflammatory process by decreasing their expression by endothelial cells.

We observed that treatment of ALK + ALCL cell lines with the PI3K inhibitor, LY294002 (data not shown), and with the mTOR inhibitor, rapamycin, resulted in decreased expression of total eIF4E.

The team found that high - aneuploidy tumors had increased expression of genes implicated in DNA replication, cell cycle, mitosis, and chromosome maintenance, yet decreased expression of genes characteristic of the infiltrating immune cells responsible for tumor destruction.

The increased expression cells are called «Runx2 knock - in» cells, and the decreased expression cells are called «Runx2 knock - down» cells.

For animal models, Yang and colleagues used molecular genetic techniques to either increase or decrease the expression of Runx2 in a mouse myeloma cell line.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

This gene regulatory code is read by proteins called transcription factors that bind to specific «DNA words» and either increase or decrease the expression of the associated gene.

Millar's group and her clinical collaborators, including Emily Chu, MD, PhD, an assistant professor of Dermatology and John McGrath, MD, from King's College, London, also discovered that cracking and scaling of palm and foot sole skin in WNT10A patients is due to decreased expression of a structural protein called Keratin 9, which is specifically expressed in these regions of skin and contributes to its mechanical integrity.

They demonstrated that, similar to mouse, Rac1 inhibition resulted in impaired branching and decreased expression of AXIN2 and FGFR2b in human lung cultures.

In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.

AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

A recent human study also indicated a genetic association of the αCaMKII gene with bipolar disorder, and decreased expression of αCaMKII has been observed in postmortem brains of patients with bipolar disorder.

Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.

Accordingly, the increased p53 activity in p53Δ31 / Δ31 fibroblasts correlated with a decreased expression of 4 genes implicated in telomere syndromes.

Increasing or decreasing expression of Sirt4 in living flies allowed the researchers to discover what function Sirt4 played in the insects — and possibly in humans.

PPI does not introduce any foreign genes into its products; rather it regulates the plant's own genes to increase or decrease expression of the genes responsible for key traits.