Sentences with word «hypoxia»

«We observed a detrimental effect of hypoxia in animals reared under low oxygen, not apparent from observations in short term studies in adults.

Despite the profound effect of hypoxia in compromising the effectiveness of radiotherapy, techniques to directly and repeatedly quantify oxygen levels in glioma in order to develop optimal hyperoxic strategies are lacking.

(b) Quantitative comparison of E-cad - / CD44 + / CD24 - cell population and E-cad - / CD44 + / CD24 + cell population in cycling hypoxia - selected subpopulations (MDA - MB 231 F3 and BCM2 F3) and their parental breast cancer cell lines.

Schneider's searches on Google Scholar reveal that the name of Sergio Leone's film, or variations thereof, occurs in the titles of no less than 2710 papers, an example being «The Good, the Bad, and the Cell Type - Specific Roles of Hypoxia Inducible Factor - 1 in Neurons and Astrocytes» -LRB-...

Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012) Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells Cell Oncol (Dordr), 35 (3), 217 - 27 PubMed 22700320

Tumors thrive in a low oxygenated environment and this condition known as hypoxia promotes the invasion of cancer and its growth (1).

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Although extensive efforts have been devoted to understanding the effect of hypoxia on tumor progression, two areas of tumor biology remain unclear.

Thus, interactome hubs such as NR1 may exhibit low levels of change in individual gene expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role in regulating the biologic response.

Nevertheless, retinal hypoxia induced by glutamate - mediated excitotoxicity is thought to be a key antecedent to such retinal diseases as glaucoma and diabetic retinopathy [39,72,73].

NOAA's National Ocean Service has been funding investigations and forecast development for the dead zone in the Gulf of Mexico since 1990, and oversees national hypoxia research programs which include the Chesapeake Bay and other affected bodies of water.

Based on his team's earlier work, Mootha wasn't surprised that the mice treated with hypoxia lived longer.

Fetal hypoxia occurs when a a fetus is deprived of sufficient oxygen during the birthing process.

So, any condition that increases hypoxia increases the risk of sickling and crisis pain.

When blood flow and oxygen levels are low, a transcription factor called hypoxia - inducible factor (HIF) triggers the production of a chemical called VEGF.

«One major adaptation is a positive selection for genes involved in hypoxia response and skeletal development, similar to those expressed in other organisms in high - altitude environments such as Tibet and the Andes,» Dr Subramanian said.

The scientists theorised that the lack of oxygen did the trick; previous studies on rats revealed that their insulin sensitivity increased under hypoxia regardless of exercise.

Conditions for hypoxia / reoxygenation cycles were optimized using two human metastatic breast cancer cell lines (MDA - MB 231 and BCM2).

The study, «A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury (SCI),» is being conducted by an experienced team of scientists and clinicians at three leading SCI rehabilitation institutions: Shirley Ryan AbilityLab (lead investigator, William Zev Rymer, MD, PhD), Kessler Foundation (Gail Forrest, PhD; Steven Kirshblum, MD), and the University of Miami (Monica A. Perez, PT, PhD).

For example, adaptation to chronic hypoxia at high altitude can suggest targets for cardiovascular and other ischemic diseases.

When genetic expression analysis was performed, researchers found significant down regulation (reduced activity) in the genes known to be responsible for causing hypoxia.

The effects of chronic prenatal hypoxia on the fetal and adult offspring cardiovascular system are prevented by maternal treatment with vitamin C during pregnancy.

Anoxic brain injuries — also known as cerebral hypoxia or hypoxic - anoxic injuries — occur when the brain receives insufficient oxygen and brain cells begin to die.

Prentice's research is focused on tissue hypoxia and ischemia and in molecular pathways of neuroprotection in stroke therapy.

Confers hypoxia tolerance.

My question is, I have developed hypoxia now but no underly8ng heart or lung problems.

Fat tissue in obese people is believed to exist in a chronic state of mild hypoxia because the small blood vessels are unable to supply sufficient oxygen to fat tissue.

By contacting an experienced hypoxia birth injury lawyer in Dallas, you'll give yourself the best chance at recovering money damages from those responsible for causing the injury.

The masks prevent hypoxia, when the body lacks enough oxygen to maintain normal physiological function.

Symptoms of hypoxia include «nausea, apprehension, tunnel vision, headaches, fatigue, dizziness, blurred vision, tingling sensations, numbness, and mental confusion,» according to the Aircraft Owners and Pilots Association.

McKenna and his team have identified four different drugs — including the anti-HIV drug nelfinavir — that can disrupt the process by which hypoxia occurs, restoring proper blood flow to the tumours and making them more vulnerable to chemotherapy (Cancer Research, DOI: 10.1158 / 0008 - 5472.

From this the scientists deduced that short - term acclimation ability observed in adults after one week does not predict the ability of their offspring to cope with low oxygen, if reared under moderate hypoxia.

The study shows that the optic nerve could be damaged due to hypoxia without a spike in eye pressure, a finding that could help unravel the details of glaucoma sufferers with normal eye pressure levels.

Our results focused on mRNA expression and not protein expression or functional NMDAR changes after hypoxia and recovery.

Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro.

Harris et al. [2] also provided evidence of the presence of retinal hypoxia in the early stages of diabetes by showing that contrast sensitivity was improved when patients with early diabetic retinopathy were made hyperoxic.

Blood lactate (LA), serum growth hormone (GH), norepinephrine (NE), testosterone, and cortisol concentrations were measured before normoxia and hypoxia exposures; 15 minutes after the exposures; and at 0, 15, and 30 minutes after the exercises.

MicroRNA - 15a inhibition protects against hypoxia / reoxygenation - induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7.

Our son Silas was born 5 weeks prematurely, and suffered grave hypoxia due to complications during the delivery.

«This follicular hypoxia triggers a cascade of biochemical changes in the cumulus cells.

When hypoxia occurs, the activity of CD45 — a protein found in myeloid and lymphoid cells — increases.