Sentences with phrase «laboratory models»

Both teams did their experiments in ferrets, a favorite laboratory model for studying transmission of influenza viruses as they mimic viral spread in humans.

In this common laboratory model, the system works extremely well.

As with results of their earlier studies, the investigators found that the higher the expression of this protein, the more aggressive the cancer, which is determined by how the cells invade other tissue types and their ability to form tumors in laboratory models of cancers.

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

Investigators tested the consequence of removing the autophagy gene known as ATG7 from laboratory models of BRAF - driven melanoma.

Using budding yeast Saccharomyces cerevisae, a frequently used laboratory model in aging research, Stowers scientists experimentally used heat and other forms of stress to induce misfolded proteins to clump together.

Our faculty, trainees, and staff work in a number of preclinical laboratory models, integrate their work into translational studies, develop new agents in collaboration with other St. Jude faculty, and use state - of - the - art clinical approaches to establish new knowledge and improve patient care.

We thank the Geophysical Fluid Dynamics Laboratory model developers for making the coupled model version 2.1 available and L. Xu, Y. Du, N. C. Johnson and C. Deser for discussions.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

Stars like the sun generate powerful internal dynamos as well, and laboratory models filled with superhot metal might be able to re-create them.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

Researchers have completed the first laboratory model of the human female reproductive cycle

A system developed a few years earlier meant that researchers could use a common laboratory model virus to study individual Ebola virus components, allowing Ebola research to extend beyond BSL - 4 labs.

While their preliminary experiments suggest the genes help control fluid levels in the cornea, Iyengar cautions that additional laboratory models will be needed to pinpoint their precise functions.

They generated a list of 18 genetic variations found only in people with Fuchs dystrophy, later narrowing the list to three most relevant to disease with the help of corneal laboratory models.

Yet that's just what researchers have done, using a seemingly simple laboratory model of rifting on the seafloor.

«Having these personalized laboratory models, which we can make in a matter of weeks, will let us test multiple different drugs on the tumor and help us bring precision medicine to individuals with bladder cancer.»

Laboratory models reveal the patterns of salt upwelling

Research teams are also developing ways to innovate the early drug - discovery process, including pioneering methods to rapidly identify drug targets and test them on laboratory models and finding and testing new therapeutic possibilities for already FDA - approved drugs.

Devised unique genetically engineered laboratory models of gliomas to identify cancer drivers and test potential therapies

For the purposes of this Prize, research based solely on computer models will not be accepted as a substitute for ocean experiments or effective, small - scale laboratory models and experiments.

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

Establishing a repository of laboratory models derived from patient tumor samples that will enable researchers to more thoroughly investigate drug resistance

In one sentence: Scientists at Pacific Northwest National Laboratory modeled every elementary step in the complicated mechanism of producing hydrogen, providing a detailed map of the amount of energy used in the different possible routes the reaction could take.

Specific Aim 3: Develop and study novel laboratory models of cancer to improve understanding of human cancers

More recent computations from the National Center for Atmospheric Research and Geophysical Fluid Dynamics Laboratory models bear this out with updated CTM simulations.

Using laboratory models of severe sepsis her group has discovered that the blood - producing stem cells fail to continuously generate mature neutrophils, which are the most critical bacteria - fighting cells.

He said experiments are under way to test the two - drug combination in laboratory models of metastasis - prone prostate cancer, leading eventually to tests in mouse models.

CD -14-0363), senior author Eileen White, associate director for basic science at the Cancer Institute of New Jersey, and colleagues tested the consequence of removing the autophagy gene known as ATG7 from laboratory models with non-small-cell lung cancer.

A new study shows that restoring the lipids that help keep lung tissue flexible and inflated can help slow disease progression in laboratory models of pulmonary fibrosis.

The scientists caution that their model, as is the case with any laboratory model, may not be exactly what occurs in people during a lengthy period of smoking, but they say it's a first step in understanding the epigenetic processes that may occur early in the transformation of cells into lung cancer.

Precessional states in a laboratory model of the Earth's core.

«Our paper demonstrates in a laboratory model how cancer can evade this class of therapy, and it provides insights into how clinical trials for these therapies could be further developed to overcome the problem of drug resistance,» he adds.

«Our interest in the body's own (innate) immune system as the culprit began when we discovered that immune system agents become activated in a laboratory model of Huntington's Disease,» he says.

Testing continues in laboratory models to better determine the VNN - 1 pathway's role in contributing to airway inflammation and hyper - responsiveness in asthma.

Some researchers say it's still not clear how closely this laboratory model, which took Steinhauer five years to perfect, mimics Hawking radiation.

Experimental physicist Daniele Faccio of Heriot - Watt University in Edinburgh calls the work «possibly the most robust and clear - cut evidence» that laboratory models can emulate phenomena at the interface between general relativity and quantum mechanics.

Laboratory Models In 1975 Ari Ben - Menahem, a seismologist at the Weizmann Institute of Science in Rehovot, Israel, analyzed the seismic waves triggered by the Tunguska event and estimated that the energy released by the explosion was between 10 and 15 megatons in magnitude, the equivalent of 1,000 Hiroshima atomic bombs.

Researchers at the Department of Pharmacy at the University of Copenhagen have recreated the complex blood - brain barrier in a laboratory model, which is based on cells from animals.

A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

In a laboratory model of sepsis using mice, the researchers found that two abnormal effects activated by toll receptor 4 during severe infection — the suppression of neutrophil production and the damage to the bone marrow's blood - producing stem cells — are mediated by two different molecules downstream of TLR4.

«Low genetic diversity in ferrets has incredibly important implications, because the ferret is now a common pet, a laboratory model organism for diseases such as influenza and SARS, and ferrets that have become feral can negatively impact native species and ecosystems,» says Kyle Gustafson, a UW postdoctoral conservation geneticist.

Their laboratory model will allow careful and controlled evaluation of the complex community of bacteria to ultimately identify those species that weaken the defenses against HIV.

Dr. Wolchok has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.

National Institutes of Health (NIH) scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus.

«It's a very complicated picture and the laboratory model of just taking one isolated chemical and giving it to a genetically pure strain of rats in clean cages, clean air and clean water and seeing what it does just doesn't come close to mimicking the human situation,» she said.

The new work not only establishes a laboratory model for Allan - Herndon - Dudley syndrome, but also hints at therapies that could prevent or reduce the debilitating effects of the disease, says Clive Svendsen, director of the Cedars - Sinai Board of Governors Regenerative Medicine Institute, a senior author of the new study and an expert on diseases of the central nervous system.

«We desperately need new therapies for this disease, and regenerative medicine approaches have shown great promise in laboratory models and in clinical trials for other conditions.»