Sentences with phrase «drug candidates»

The essential protective function of this barrier is also a red light for 98 % of drug candidates for the treatment of the central nervous system.

It is a promising drug candidate for treating ADHD (attention deficit hyperactivity disorder).

That makes it relatively simple to gauge the effectiveness of large numbers of drug candidates in treating a condition caused by a particular mutation.

Worse, many promising drug candidates fail in phase II clinical trials when their efficacy is put to the test.

The patent attorney's involvement may commence with the discovery of a new class of potential drug candidates, and then continue right through the product's development.

In only a few years, our unique approach has identified drug candidates with the potential to treat major diseases, demonstrating that regeneration could be as simple as taking a pill.

A leading drug candidate has more funding and is further advanced, but it also faces obstacles.

This can help identify new molecules likely to inhibit certain therapeutic targets and to lead to novel drug candidates.

In the past year and a half, laboratory scientists have discovered three drug candidates with the potential to activate regeneration in humans.

Their research also shows that new cancer drug candidates can be identified faster and at lower cost by using computer - assisted and cell - based screening of compounds.

Furthermore, the cells offer a renewable, long - lasting model system for testing drug candidates or gene modifications that may offer new treatments, personalized to individual patients.

This demonstrates the numerous opportunities for data mining, designing drug candidates, developing models to predict biological activity, and studying interactions between cellular targets and synthetic molecules.

This knowledge could have a major impact on the development of a pair of highly potent new antibiotic drug candidates.

We have a large pipeline of promising drug candidates fueled by a bold vision to one day cure cancer.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

This includes sharing drug candidate structures and positive and negative results.

And this enables scientists to narrow their field of drugs candidates rapidly, ultimately bringing forth development candidates that can advance into and through the clinical development process.

Drug candidates currently in late stage clinical trials comprise of growth factors, which are traditional protein - based biological drugs associated with high costs, and some trials have been prematurely terminated.

The development of a project from target protein to potential drug candidate requires the integration of many disciplines and allows scientists to be exposed to techniques far from their own expertise or knowledge.

If drug candidates proved successful, they would then be made available for the initiative's commercial sponsors to buy and bring to market.

This results in potent and highly specific drug candidates.

Increasing the number of comparative oncology studies means more and more cats and dogs will have access to the latest drug candidates.

They have also established screening methods to identify drug candidates.

To date, we have discovered and developed three approved drugs, and we have drug candidates in every stage of development.

Even with promising drug candidates, there are often studies that show negative effects, for instance if the dose was too low or the timing of the drug's administration wasn't ideal.

Source: Biogen and Ionis Expand Strategic Collaboration to Develop Drug Candidates for a Broad Range of Neurological Diseases; Press Release

«It will help achieve our common goal of rapidly advancing new drug candidates into the clinic.»

The biopharmaceutical industry will also increase its spending as it moves new drug candidates into development and clinical trials.

Working in the laboratory of John Tainer, Daniels solved the structure of AGT alone and in complex with two inhibitors that were in early development as drug candidates for combating resistance.

We are very enthusiastic about our most advanced drug candidate, LYS - SAF302, which is nearing pivotal clinical testing for the treatment of MPS IIIA.

At the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO), University of Colorado Cancer Center researchers reported results of a Phase I trial of OMP - 54F28 (FZD8 - Fc), an investigational drug candidate discovered by OncoMed Pharmaceuticals targeting cancer stem cells (CSCs).

Nightingale's high - throughput platform can also be used to discover novel drug candidates through PheWAS approaches.

Enterome's EB8018, a First - in - class Drug Candidate Targeting Crohn's Disease, Successfully Completes Phase I Study in Healthy Volunteers — Enterome — Cision (same as above link, more detail)

When the results are announced, they indicate that Medico's drug candidate works better than expected as a treatment for skin cancer.

Hands - on Group leader / Associate director to support DMPK - clinical pharmacolgy of drug candidate from drug discovery to Phase I / II clinical studies

Several years ago, for example, poor chemical probe data led researchers to pursue a final stage clinical trial on a cancer drug candidate called iniparib.

We have the expertise and the patented technology required to develop siRNA based drug candidates internally as well as to establish fruitful collaborations with suitable partners.

Excitingly, because stem cells can produce such large numbers of neurons, we can even test for and identify new drug candidates using patient specific neurons.

Li Ying's group in Shanghai synthesized artemisinin derivatives that were more potent at killing malaria parasites and had more desirable chemical properties (such as solubility in water), making them better drug candidates than natural artemisinin.

An affordable hepatitis C combination treatment including the new drug candidate ravidasvir has been shown to be safe and effective, with extremely high cure rates for patients, including hard - to - treat cases, according to interim results from the Phase II / III STORM - C - 1 trial presented by the non-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) at the International Liver Conference in Paris.

The research team will now focus on making changes to the harmine and its relatives (harmalogs) to find drug candidates that target only beta cells.

«Working closely alongside the drug development teams at Merck offers an outstanding opportunity to create new benchmarks for the R&D process, with the ultimate goal of optimizing drug candidates earlier by testing them in Organ - Chips that mirror what happens in the patients whom the medicines are designed to treat and cure,» said Geraldine A. Hamilton, Ph.D., President and Chief Scientific Officer of Emulate.

«Attractive drug candidate identified to target glioma brain tumors.»

Dr. King points out that a number of oral drug candidates inhibit PKC - delta and that it may be possible to suppress PKC - delta production with microRNAs (small RNA molecules that help to regulate protein generation).

Up the road in Bar Harbor, MDI Biological Laboratory and its spinout company, Novo Biosciences, said they have identified a potential drug candidate derived from a shark that may restore heart muscle function after a heart attack.

For example, their discovery that the major antioxidant urate is a biomarker of both lower risk and favorable progression of Parkinson's prompted rapid pursuit of a disease - modifying drug candidate now in clinical development.

Artificial intelligence to better target identify both experimental drug candidates and the right patients for clinical trials — and a more streamlined supply chain — could go a long way.