Sentences with phrase «in different cells»

\ n \ n - Whether one needs the same cocktail of genes in every different cell type to get to the same stage of potency remains to be seen.

All cells in the human body contain these bases in exactly the same order, but different genes are expressed in different cell types, allowing them to carry out their specialized functions.

The same gene may likewise be expressed differently in different cells of a single person.

But in reality, the same sequences often behave differently in different cells.

For example, it is hard to obtain the same gene expression in different cells, even if they are grown in the same medium.

Rather than analyzing groups of cells, they performed a comprehensive analysis of the genes that are expressed in the different cells at a single cell resolution.

Those switches can be both near and far from the gene they regulate and act in different combinations in different cell types to give each cell type a unique genomic identity.

She adds that it is also unclear why distinct patterns of these sites are observed in different cell types and under different drug treatments.

The remaining part, much of which describes how these proteins should be expressed in different cells and tissues, could not be understood.

The results, although still preliminary in a quantitative sense, demonstrate that the reactivation of methylation - silenced genes does occur in different cell lines, suggesting it is a general phenomenon.

On the other hand, if the same mutation occurs in a different cell population located farther away from the SVZ, it will give rise to other subtypes,» said Chen.

«We compiled a list of the proteins we thought Zika and similar viruses like dengue were using to get inside of cells, and then we looked to see which of these proteins were abundantly present in the different cell types of the developing brain,» said Pollen, who did the work with Tomasz Nowakowski, PhD, and a UCSF graduate student Carmen Sandoval - Espinosa, BS, both in Kriegstein's lab.

In the first step, stainings in different cell lines with the same antibody are reviewed and the results are compared with available protein / gene characterization data for subcellular location.

«We want to know how this system works in all different cell types and in plants that we are interested in for biofuels.»

Thus, the ESTs have usefulness, or patentable utility, for diagnostic evaluations of specific protein kinases in different cells, for example.

In order to isolate the 3D structure of the chromosome during metaphase, the authors used a combination of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points of contact along the mitotic chromosome in different cell types synchronized to divide at the same time.

Kelley and his team also used mice with fluorescent markers in different cells of the ear followed by next generation sequencing.

TAZ helps to regulate how different genes operate in different cell types.

Answering these questions leads to consideration of the role that hormones — insulin, in particular — play in stimulating fat accumulation in different cells.

«When different scientists are able to get the same results in different cells from different patients, we can have more confidence that we are really on to something that will be beneficial for patients.»

The lead authors of the article, Hani Goodarzi, formerly a postdoc in the lab and now a new assistant professor at UCSF, and research assistant Hoang Nguyen, devised and applied a new method that utilizes state - of - the - art genomic sequencing technology to measure the amount of tRNAs in different cell types.

In a paper published earlier this year in Molecular Cell, he and his team explored the activity of the FOS / JUN protein complex, which is expressed across many different cell types in the brain but appears to regulate unique programs in each different cell type.

«It just needs the Cre reaction to turn it on, and there are many mouse lines available that express Cre in different cell types.»

Christian Seiser says: «Our results highlight that it is crucial to understand the individual role the various HDAC variants in different cell types and hence different types of cancer, before HDAC inhibitors can be used safely as therapeutics.»

This was extremely challenging, since many disparate functions have been attributed to Alix in different cell types.

The team is now working on finding out how PTEN is regulated in different cells.

In addition, it had been reported that sofosbuvir was protective against Zika in different cell types.

He explains, «To our knowledge, this is the first radiotracer to interrogate the activity of PATs, which play a role as multi-purpose carriers with distinct roles in different cells.

Both types of cells are derived from the same progenitors, but in different cell cycles.

Expression of Snail represses expression of E-cadherin and induces EMT in different cell types, including breast cancer cells [36, 37].

Her group studies how the cell cycle is controlled in different cell types within a multicellular organism.

There has been a significant trend in biotechnology with companies investing in different cell therapy workflows.

Understand the molecular mechanisms involved in different cell types and organisms to explain the differences in efficiencies

Only within the past few years were members of the project able to start classifying, annotating and analyzing the millions of images they had captured of subcellular structures in different cell types.

Hypoxic effect on breast cancer stem cells in different cell types.

Lue, whose essay described the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.

Allinase is found in different cells to alliin, cleanly separated by the cell walls, so the reaction occurs immediately after slicing the root with a knife.

The results, which focus on two choices near the start of embryo formation, show that, when cells are making decisions about what to become, there is greater variation in the activity of the genes in different cells — the same genes may be turned on in some cells and off in others.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

In recent years, research at Joslin and elsewhere has shown that insulin resistance may work differently in different cell types.

The number of receptors for the neurotransmitter in the brain amounts to 14, occurring in different cell types.

Understanding how a particular DNA sequence gives rise to a particular protein provides us with some insight into that protein, but a deeper investigation of how the protein is made, where it is located, and how much of it is present in different cell types is required to enable a true understanding of its function.

Myriad control switches help to arbitrate how genes get expressed in different cells and tissues, and those switches are often triggered by maternal diet, toxic exposures and many other environmental factors.

HDAC3 functions on the epigenome, the molecular component of the cell nucleus that specifies which genes are expressed — and just as importantly, which ones are not — in different cells of the body.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.