Sentences with phrase «in embryonic stem cells»

So researchers began testing genes that were only active in embryonic stem cells to try to pin down those capable of triggering the change.

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

Establish a world - wide consortium of mouse production centers to generate germ line transmission of targeted knockout mutations in embryonic stem cells for all known and predicted mouse genes.

It will appeal to those interested in adult stem cells as well as those interested in embryonic stem cells.

These are the same four genes that seemed to be very active in embryonic stem cells.

Despite the federal ban, for the past five years California has led the country in embryonic stem cell research by taking advantage of $ 3 billion in voter - approved funds and millions more in private foundation grants.

The study, «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» was supported by the National Institutes of Health.

«Long - held assumption of gene expression in embryonic stem cells challenged.»

Histone demethylation through JMJD5 is found to be vital for the cell cycle and maintenance of pluripotency in embryonic stem cells

This Korean researcher racked up a series of important advances in embryonic stem cell technology, including the first lines of cells from patients

When the studies of mitochondrial carryover were done in embryonic stem cells derived from ePNT blastocysts (to allow for more cell divisions during which instability could manifest), some stem cell lines displayed instability and an increase in mitochondrial DNA carryover with time.

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

Research has revealed a new understanding of how an open genome structure supports the long - term and unrestricted developmental potential in embryonic stem cells.

N. Yasui et al., «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» Molecular Cell, doi: 10.1016 / j.molcel.2014.05.002, 2014.

From RNAi Screens to Molecular Function in Embryonic Stem Cells.

Suppose you run a ChIP - seq experiment (think «GPS for proteins») for NANOG, an essential transcription factor in embryonic stem cells (ESCs).

It can be used in embryonic stem cell research, or in regenerative medicine where it is sometimes referred to as «therapeutic cloning.»

Researchers called them induced pluripotent cells, which are created by enticing cells to turn on genes normally found in embryonic stem cells.

Those, along with genes already known to be important in embryonic stem cells, totaled 24, and, using a virus to carry them, he inserted the genes into skin cells taken from the tail of a mouse.

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

Paired SAGE - microarray expression data sets reveal antisense transcripts differentially expressed in embryonic stem cell differentiation.

In her article «Stem Cells and Babies» (August / September), Maureen Condic outlines a variation of cloning that she and her colleagues hope will produce the equivalent of embryonic stem cells» while bypassing the production of an actual human embryo, thus overcoming intrinsic moral problems entailed in embryonic stem cells for research.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

But Mary Herbert, a reproductive biologist at the University of Newcastle, UK, who is part of a team pursuing mitochondrial replacement, says that mitochondria behave very differently in embryonic stem cells compared to normal human development.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

As a pilot project, Niakan plans to knock out OCT4, a gene that is turned on in embryonic stem cells in both humans and mice.

Why heterochromatin is organised in this way in embryonic stem cells has previously been unknown.

Previous research has shown that heterochromatin is maintained in an unusually open and uncompacted organisation in embryonic stem cells, which is different to all other cell types.

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.

Friedrich G, Soriano P., Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells.

Tensions are growing in Berlin ahead of a parliamentary vote that medical scientists say will determine whether or not Germany can continue to participate effectively in embryonic stem cell research.

Dr. Hanna is a Senior Scientist in the Department of Molecular Genetics at the Weizmann Institute of Science in Israel, where he explores topics in embryonic stem cell biology, early embryonic development and the modeling of human diseases.

Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 — the aberrant inheritance of which results in the condition.

BRD7, a novel PBAF - specific SWI / SNF subunit, is required for target gene activation and repression in embryonic stem cells.

FoxP1 promotes midbrain identity in embryonic stem cell - derived dopamine neurons by regulating Pitx3

Moreover, the findings are not too dissimilar to those reported previously by Shoukrat Mitalipov in 2015 showing a drift in the mitochondrial heteroplasmy in embryonic stem cells established following somatic cell nuclear transfer or induced pluripotent stem cell reprogramming.

We'll start with ChIP - seq data from the ENCODE project, find enhancers in embryonic stem cells, and conclude with a targeted CRISPR screen that can disrupt these enhancers.

Epigenetics; reprinted from Meshorer, E., Imaging chromatin in embryonic stem cells (July 11, 2008), StemBook, ed.

Genes typically active in embryonic stem cells roared to life, triggering the adjacent foreign DNA to provide antibiotic resistance.

To determine whether huntingtin is involved in trafficking a specific subset of proteins, we measured changes in global transcription levels in embryonic stem cells and neurons lacking huntingtin.

After his postdoctoral training, he turned his attention to proteostasis in cells that can not age, namely in embryonic stem cells.