Sentences with phrase «preclinical models»

Over the last five years, promising results in preclinical models of SMA have led to a surge of clinical trials using small molecules, oligonucleotide - based therapies, and viral - mediated gene therapies.

5 - HT2C agonists have demonstrated efficacy in preclinical models of depression, obesity, and psychosis.

«Stem cell - based therapy for targeting skin - to - brain cancer: Stem cells loaded with oncolytic viruses show promising results in preclinical models for targeting skin cancer metastases in the brain.»

currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2018.

This proof - of - concept study used preclinical models to demonstrate that the device was effective in reducing the cancerous tumour in the living brain.

Recent approval from the U.S. Food and Drug Administration to begin clinical studies was based on compelling activity upon IACS - 10759 treatment in multiple preclinical models of AML.

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.

Development of advanced preclinical models are needed to further elucidate the complex mechanisms underlying asthma exacerbation and investigate new therapeutic strategies.

PHENOMIN - CIPHE develops functional genomic approaches to create preclinical models of the immune system.

These cancer stem cells were used to create preclinical models relevant to human glioblastoma.

E. Intensify research on the major drivers of childhood cancers Improve our understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.

M1: Passive transfer studies in preclinical model performed; Report on protection by passive therapy with human immune IgG

With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in preclinical models which is encouraging for the potential of this product as a monotherapy, combining immune - modulation and antibody dependent, cell - mediated cytotoxicity,» said Michel Detheux, Ph.D., Chief Executive Officer of iTeos.

Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and can be utilized as preclinical models for therapeutic testing and efficacy.

«There is movement to develop treatments for ALD and AMN, but these are limited because we need better preclinical models of the disorder,» he says.

A novel, synthetic, DNA - based strategy to provide protection against a broad array of influenza viruses has been developed in preclinical models by scientists at The Wistar Institute, MedImmune (the global biologics research and development arm of AstraZeneca) and Inovio Pharmaceuticals, Inc..

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

The authors thank Shengbin Yang from the Johns Hopkins Lung Disease Preclinical Model Core for performing the animal exposures.

Developing therapies and testing drugs using current preclinical models have limitations in reliability and predictability.

Complementing the company's in - house Crispr programme, the technology will identify and validate new targets in preclinical models across a range of disease areas.

His research efforts are divided between preclinical models, the development, performance, and monitoring of cancer immunotherapy trials and the training of the next generation of translational investigators.

Before PCSK9 inhibitors can be approved for widespread use, further research into PCSK9 function using suitable preclinical models is needed.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Currently, Doody is testing in preclinical models whether combining this agent with other, known rheumatoid arthritis treatments results in more efficacious therapies.

Study results showed that in preclinical models tumor - to - background ratios obtained from 11C - sarcosine PET were significantly elevated compared to 11C - choline.

«We've relied almost exclusively on murine preclinical models, and we've been able to show that investigational agents are very good at fighting cancer in these models,» he said.

He notes that earlier published studies involving preclinical models suggest that may be the case but that further human studies are needed.

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

Xeno - Free and Defined Human Embryonic Stem Cell - Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large - Eyed Preclinical Model

Collectively, the data gathered from these two preclinical models offers a dynamic portfolio of PTSD - relevant behavioral profiles (anxiety, social avoidance, abnormal fear regulation) that can potentially be utilized as a tool to screen novel drug compounds.

In order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical models.

In order to fill the current gap in PTSD treatment research and increase our understanding of the underlying neurobiological and pathophysiological mechanisms, the development and validation of robust preclinical models with high face and construct validity is absolutely necessary.

This is the first preclinical model of stomach cancer that repeats the pattern of human stomach cancer development, that involves progression from chronic stomach inflammation through to fully invasive cancer,» Dr Putoczki said.

Preclinical models demonstrated that CTLA - 4 blockade could augment anti-tumor response [12].

developing and implementing new or improved preclinical models with greater relevance to the target product profile (TPP) and clinical vaccine efficacy

For instance, we're using this information to identify subtype - specific therapeutic vulnerabilities, which can then be examined for their «druggability» in our powerful preclinical models.

Projects include developing a novel preclinical model of ischemic stroke and applying functional MRI to characterize brain changes, improving measures of post-stroke clinical assessment, and combining brain stimulation with directed rehabilitation.

Future preclinical models / clinical trials will assess in vivo efficacy and safety for these cells, and furthermore, this strategy also has the capacity to be used for other important genetic diseases.

Our results differ, which perhaps reflects the protocols used and the organ transplanted, as these investigators used a renal transplant model in a large preclinical model.

Duke s research will use patented multielectrode technology to directly measure the activity of hundreds of neurons to study brain dynamics in unique preclinical models of diseases such as Parkinson s and schizophrenia.

In multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapy.

«Future studies will aim to explore the relationship between SND1 and STAT3, identify additional microRNAs that may be relevant to malignant glioma and explore the effects of drugs that block SND1 expression in more advanced preclinical models.»

The goal of this Center of Excellence is to better define thrombus development in patients with cancer, test the efficacy of novel therapies, develop new preclinical models, and create and expand biorepositories to provide a valuable resource to researchers across Cleveland Clinic.

M2: Vaccination studies in preclinical model performed; Report on safety, immunogenicity, and preclinical efficacy of leading placental malaria vaccines product candidates

With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in preclinical models which is encouraging for the potential of this product as a monotherapy

Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and utilized as preclinical models for therapeutic testing and efficacy.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.