Sentences with word «allelic»

Four dogs with this allele were DNA sequenced, and none contained the SNP of allelic variant 1.

Unfortunately, a decade after the popularization of GWAS and in spite of much effort, we have fallen short of the goal of explaining most of the heritability for complex traits in terms of allelic effects.

CONCLUSIONS: These results suggest that the behavioral expression of allelic variation in MAOA activity is sensitive to social experiences early in development and that its functional outcome might depend on social context.

Osborne, M., Gomez, D., Feng, Z., McEwen, C., Beltran, J., Cirillo, K., El - Khodor, B., Lin, M. Y., Li, Y., Knowlton, W. M., McKemy, D. D., Bogdanik, L., Butts - Dehm, K., Martens, K., Davis, C., Doty, R., Wardwell, K., Ghavami, A., Kobayashi, D., Ko, C. P., Ramboz, S. & Lutz, C. Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models.

Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance

The authors conclude that»... by 4400 years ago, early farmers had already had a substantial homogenizing effect on allelic diversity at three genes associated with maize morphology and biochemical properties of the corn cob.»

Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity

In recurrent selection (RS), multiple genotypes are crossed and the resulting plants are intercrossed to increase the chance of creating novel allelic combinations.

Ritchie KA, Brinster RL, Storb U. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in k transgenic mice.

Allelic association with aggression in dogs was observed in the gene coding for the receptor HTR1D [96].

To further determine the specificity of the mediating role of collectivistic cultural values on the association between allelic frequency of the 5 - HTTLPR and mental health disorders, we also conducted regression of mediation on 5 - HTTLPR, individualism — collectivism and two mental health disorders included in the 2008 WHO Mental Health Survey, but not previously associated with the 5 - HTTLPR, namely substance abuse and impulse control.

The human serotonin transporter gene linked polymorphism (5 - HTTLPR) shows ten novel allelic variants

Next, the primary research questions were addressed by examining the moderating effects of allelic group on task - specific brain activation.

Having thus created a list of loci with likely allelic mapping bias, we were able to tackle the main question of our paper: whether these biased reads give rise to biased quantifications and false eQTLs.

By looking at your specific allelic variants of your HLA family of genes, genetic testing can help you determine if genetics play a role in your gluten sensitivity.

We examined the influence of a common allelic variation in the dopamine receptor D4 (DRD4) gene and caregiver quality on temperament in early childhood.

Prior to characterization of this disease at the molecular level, elegant interbreed crosses were undertaken to determine that the phenotypically similar diseases that were segregating in multiple breeds, including the miniature poodle, the English and American cocker spaniels, the Labrador retriever, the Australian cattle dog, the Nova Scotia duck tolling retriever and the Portugese water dog, were in fact allelic [19, 20].

Supposing that a species has only 1000 genes each in ten different allelic forms (both figures are overly conservative estimates), 101000 gene combinations are potentially possible.

The research, conducted by Ivan P. Gorlov, PhD, Olga Y. Gorlova, PhD, and Christopher I. Amos, PhD of the newly formed Department of Biomedical Data Science, was shared in «Allelic Spectra of Risk SNPs Are Different for Environment / Lifestyle Dependent versus Independent Diseases,» and published in PLOS Genetics.

These reference standards consist of human genomic DNA fragmented to 160 base pairs, representative of plasma - derived cfDNA, and are provided as a set of precisely defined allelic frequencies from as low as 0.1 %.

Allelic complexity in genes will be large, and such complexity will make the analysis of genotype - phenotype relationships difficult, particularly in the situation of common, complex diseases.

Junji Hirota at Tokyo Tech and team focused on discovering a long - range enhancer for a large gene cluster, finding an evolutionary conserved sequence motif in mammalian evolution, and elucidating enhancer - dependent allelic preference or exclusion mechanism for odor - detecting receptor genes.

Cxcr4 allelic disruption efficiencies as determined by either deep sequencing or the Surveyor nuclease assay were comparable, and were approximately 10 % at an MOI of 100, 20 % at an MOI of 300, 34 % at an MOI of 600, and 38 % at an MOI of 1000 (Figure 2B).

METHODS: We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis of the association between the FTO region and obesity.

Consistent with a causal relationship, (16) reports that the prevalence of limited physical functioning in aging varies depending on p16Ink4a allelic variation, consistent with variations in rate of stem cell attrition with senescence.

We are continuing this analysis as the leaders of the imprinting subgroup in GTEx, with particular interest in variable imprinting and molecular mechanisms of allelic silencing.

Our results now show that a particular set of psq allelic combinations gives rise to embryos with terminal defects.

Colonies # 1, # 7, # 13 and # 14 carry mono - allelic mutations of MSTN.

However, because of allelic segregation in gametes of the F1 hybrid parents, the genetic backgrounds of individual C57BL / 6J x 129 F2 mice vary, and they are only an approximate genetic match to the B6; 129 background.