Sentences with phrase «circadian clock»

The role of circadian clocks in modulating nutrient responses.

«The results are profound, for a number of different reasons,» says Steven Kay, a geneticist at the Scripps Research Institute in La Jolla, California, who studies circadian clocks in plants.

«Important metabolic functions are also heavily influenced by circadian clocks, which is why activities such as chronic night - shift work — which can cause a misalignment of this clock — increase one's risk for metabolic and autoimmune diseases such as obesity, Type 2 diabetes, cancer and multiple sclerosis,» said Dr. Akassoglou.

But after scientists discovered human circadian clock genes in the late 1990s, they found that the genes were expressed in tissues throughout the body.

Circadian clocks regulate functions ranging from alertness and reaction time to body temperature and blood pressure.

However, what was most fascinating, say the researchers, was how a drop in p75NTR levels then affected a variety of circadian clock systems.

In fact, sleep researcher Dr. Michael Breus explains that camping for one week (away from artificial light) resets circadian clocks.

«Studies strongly suggest a link between circadian clocks, insulin resistance and diabetes development,» explains Charna Dibner, the co-director of the study.

Entrainment of the human circadian clock to the natural light - dark cycle.

He is familiar with circadian clocks and especially jet lag as important performance factors that can affect performance.

Determining how circadian clocks work is crucial to understanding several human diseases, including sleep disorders and depression in which the clock malfunctions.

These researchers gave the mice synthetic agonists to certain nuclear receptors that are involved in controlling expression of circadian clock proteins...

A light - and temperature - entrained circadian clock controls expression of transcripts encoding nuclear proteins with homology to RNA - binding proteins in meristematic tissue.

Many of the body's processes follow a natural daily rhythm or so - called circadian clock, so there are certain times of the day when a person is most alert, when the heart is most efficient, and when the body prefers sleep.

Cry1 and Cry2 displayed a daily variation in the retina as expected for circadian clock genes, while Cry4 expressed at constant levels over time.

Circadian clocks help organisms synchronize their biological activities to the time of day.

«Genes discovered linking circadian clock with eating schedule.»

«In 2015, we had reported the synthesis of a molecule with demonstrated period - shortening activities on mammalian circadian clocks discovered through a collaboration between ITbM's chronobiologists, synthetic chemists and theoretical scientists,» says Yoshimura.

Because humans have the «identical circadian clock machinery» as mice, adds Bass, the work has important implications for scientists studying obesity and diabetes in people.

The pineal hormone melatonin is synthesized and released with a robust daily oscillation that is regulated by the master circadian clock in the SCN and ambient light exposure (15).

Researchers discovered that how proteins wiggle, jiggle, and shape - shift by the hour is central to figuring out how circadian clocks work.»

The authors suggest that humans may have internal clocks that track the lunar cycle, much like circadian clocks that sync up with the rise and fall of the sun.

«All of a sudden we've got access to a plant that's as genetically handleable as a fruit fly,» says Mike Menaker, a veteran of circadian clock research at the University of Virginia, in Charlottesville.

«Circadian clocks actually keep us from going into chaos,» he added.

The researchers observed that even though the subjects» days had been abnormally extended by four hours, their body temperature and melatonin and cortisol levels continued to function according to their own internal 24 - hour circadian clock.

February 25, 2015 Epigenetic «switch» regulates RNA - protein interactions Chemical changes — also known as epigenetic modifications — to messenger RNA (mRNA) are thought to play an important role in gene expression, and have recently been found to affect biological processes such as circadian clock management and obesity.

Sequencing the genome has already revealed a few surprises, such as the organism's potential ability to sense red light, which is part of the mold's internal circadian clock or sensitivity to light patterns.

When we are exposed to light, our bodies» central circadian clock in the brain resets.

«Our studies have shown that DHEA probably acts primarily on the peripheral circadian clocks rather than on the master clock in the central nervous system, which has control over clocks in the entire body,» explains Yoshimura.

«We found that the bacterial circadian clock responds only to metabolic activity,» Rust said.

Many organisms use circadian clocks to regulate their activities but we don't know much about bacterial clocks.

Exceptionally short - period circadian clock in Cyclosa turbinata: regulation of locomotor and web - building behavior in an orb - weaving spider.

Early work in plants and insects had, in fact, established the existence of such circadian clocks, but it wasn't until the mid-1980s that the researchers uncovered the inner molecular workings behind this basic process.

Using the fruit flies, they showed how circadian clock neurons use thermoreceptors to constantly monitor the temperature of their environment.

Saper and his colleagues have been studying the brain's suprachiasmatic nucleus, or SCN, which resets our daily circadian clock, and the genes that control wakefulness.

TIME WARP This spiny orb weaver and two of its relatives may have evolved an impossibly short circadian clock by spinning their webs before dawn to avoid predators.

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function.

They found that PIF4 is, in turn, regulated by another protein called Timing of CAB Expression 1 (TOC1), which is a part of the biological circadian clock proteins that accumulate at the end of the day.

TAKING ITS TIME Circadian clocks in some animals tick - tock to a different beat, like this member of brood II, one of the 17 - year cicada species that emerged in 2013.

Kay says the study also «raises the possibility that many other bacteria maintain circadian clocks.

The molecular circadian clock coordinates the body's rhythms fine - tuned by environmental cues, such as light, to the 24 - hour solar cycle.

The Physiology or Medicine Prize recognized work on how several genes work together to control the basic circadian clock, encoding proteins that build up during the night and are broken down during the day.

Furthermore, we are examining the role of various circadian clock components in modulating lifespan in response to nutrient variation in the diet.

Despite these constant environmental conditions, Daphnia PER mRNA levels oscillated with a 24 - hour rhythm, a clear indication of a functional circadian clock.

Variants in the core circadian clock gene Crytochrome 2 (Cry2) have also been recently associated with fasting glucose concentrations and type 2 diabetes risk (17, 18).

Extended effects of evening meal carbohydrate - to - fat ratio on fasting and postprandial substrate metabolism Circadian clocks optimally adapt to sunlight for reliable synchronization Sofer S, Eliraz A, et al..

The diversity of the various cell types displaying circadian clock activity suggests that for many tissues correct timing is important enough to warrant keeping track of it locally.

«What makes circadian clocks tick?