Sentences with phrase «coding sequence»
A "coding sequence" refers to a specific part of DNA that contains instructions for making proteins. It is the portion of DNA that tells cells which amino acids to join together to create a protein, which is important for the functioning and development of living organisms. Full definition
The presence of such sequences could provide organisms with a way to modify their gene expression without altering the actual coding sequence of genes.
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Of the 200,000 + genetic markers that we use, roughly 10 % of them fall in coding sequence.
Using data from experiments that simultaneously measure the effects of thousands of mutations, I develop computational tools to predict the functional impact of mutations in protein coding sequences.
Put a different way, protein - coding sequences altogether make up a modest 20,000 genes in humans.
Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, only their protein coding sequences are defined.
We have investigated CACNA1C expression in six regions of post-mortem human brain by Nanopore sequencing of the complete coding sequence from expressed transcripts.
The kit includes lyophilized Xfect Transfection Reagent and gesicle packaging mixes which contain coding sequences for the nanovesicle - inducing glycoprotein, Cas9 endonuclease, and CherryPicker red fluorescent protein.
Genomic sequencing of the isolated virus revealed that it is closely related to Tembusu virus (a mosquito - borne Ntaya group flavivirus), with 87 — 91 % nucleotide identity of the partial E (envelope) proteins to that of Tembusu virus and 72 % of the entire genome coding sequence with Bagaza virus, the most closely related flavivirus with an entirely sequenced genome.
After assembling the sequences of all RT - PCR products, we obtained the entire coding sequence of BYDV - byd1 (GenBank Accession JF312912).
A significant proportion of SVs affect known protein - coding genes by altering coding sequence or gene dose.
At the time of this research, these giant genes are only surpassed in length by the human titin coding sequence which is 38,138 amino acids long.
In this webinar, out expert guests will discuss the current understanding of how and why gene coding sequences influence protein expression, and ways in which this understanding can help shape strategies to design genes for applications ranging from synthetic biology to protein crystallography.
Conventional methods for identification of both RP mutations and novel RP genes involve the screening of DNA coding sequences.
In most cases the putative coding sequences of OR and V1R genes span a single exon and the additional exons contains only UTRs.
List of VR and OR genes that have introns within the annotated coding sequence.
We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.
The point being that nobody knows how different the intron or non-protein coding sequences are between humans and other primates because the research quoted is only on the exons, or protein coding portions of the genome.
This results in the inclusion of extra coding sequences in the mRNA, which when translated, end up producing malfunctioning haemoglobin molecules.
Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite.
With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse genetics to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence.
While the two actin isoforms differ by only four amino acids, their mRNA coding sequences differ by almost 13 percent because of «silent» nucleotide differences that nevertheless encode the same amino acids.
These phenotypes appear to result from mutations in a specific portion of the SPTAN1 coding sequence, and preliminary findings indicate that the location of the mutation could potentially predict disease severity.
To determine whether FLRG can also inhibit myostatin activity in vivo, I generated a construct in which the FLRG coding sequence was placed downstream of a myosin light chain promoter / enhancer.
An out - of - frame overlapping reading frame in the ataxin - 1 coding sequence encodes a novel ataxin - 1 interacting protein.
It's by no means simple, but we have the strong starting point of understanding that variants in coding sequences likely alter protein sequence and / or structure.
They found that 54 % of the variations in mRNA abundance can be explained by the presence of motifs upstream of the gene, while the gene coding sequence alone explains 30 % of the variations in mRNA abundance.
cDNA libraries, which consist of plasmids that over-express coding sequences from a given cell type or organism, have been used in a similar manner to Cas9 activators.
The remaining cassette can invert as long as Cre remains expressed; once Cre is removed from the system, the fluorescent protein whose coding sequence is closest to the promoter will be expressed.
An adult C. elegans with GFP coding sequence inserted into a histone - encoding gene.
Sequencing and BLAST analysis recealed a 87 — 91 % / 87 % nucleotide identity with a partial coding sequence from the Tembusu / Sitiawan virus E gene (encoding the envelope protein)(Fig. 7A).
This allele deletes 433 bp of a 1083 bp long coding sequence, rendering the GPCR non-functional.
The game incorporates a large degree of puzzle - solving in its gameplay, with most of the puzzles requiring you to enter code sequences using the square, triangle, circle, and x buttons.