Sentences with word «endocytic»
"Endocytic" refers to the process by which a cell takes in or engulfs materials from its external environment into its own internal compartment. Full definition
Quantum dot - loaded monofunctionalized DNA Icosahedra for single particle tracking of endocytic pathways Nature Nanotechnology (2016) Dhiraj Bhatia, Senthil Arumugam, Michel Nasilowski, Himanshu Joshi, Christian Wunder, Valerie Chambon, Ved Prakash, Chloé Grazon, Brice Nadal, Prabal K. Maiti, Ludger Johannes, Benoit Dubertret, Yamuna Krishnan
science.institut-curie.org
Figure 2: Left: dual - colour diffraction limited image of endocytic proteins in yeast.
Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking.
We now aim at unraveling molecular and functional links between endocytic sorting at the plasma membrane and retrograde sorting on early endosomes.
«Non-small cell lung cancers can be sorted in clusters by endocytic changes: Sorting cancer by defective endocytosis genes.»
Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.
The feedback, which couples the initiation of endocytic waves by clathrin to cortical actin waves is analogous to a group of people walking on a wobbly bridge.
Amphiphysin isoforms have a putative role in membrane deformation at endocytic sites.
Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.
Clathrin endocytic waves were identified here as the upstream initiator of cortical actin waves.
A host of endocytic processes has been described at the plasma membrane of eukaryotic cells.
We hypothesized that certain lectins link glycosylated cargo proteins and glycosphingolipids into molecular nanoenvironments from which endocytic pits are formed without the help of the cytosolic clathrin machinery (Figure 1).
In HeLa cells, Shiga toxin B - subunit is transported from the plasma membrane to the endoplasmic reticulum, via early endosomes and the Golgi apparatus, circumventing the late endocytic pathway.
In what concerns intra-membrane constituents, the focus of interest has been on phosphatidylinositol lipids and their capacity to orchestrate endocytic events on the cytosolic leaflet of the membrane.
Cell surface receptors can be endocytosed by both clathrin - dependent and clathrin - independent mechanisms, but, as yet, there is no clear understanding of why alternative endocytic routes exist or how receptors are committed to a particular route.
As endocytic proteins such as F - BAR have been found to play a role in cortical actin waves, the researchers sought out to understand the link between endocytosis and cortical actin waves.
Furthermore, sugar modifications on extracellular domains of proteins, and sugar - binding proteins, termed lectins, have also been linked to the uptake of endocytic cargoes at the plasma membrane.
We are using the epidermal growth factor receptor (EGFR) as a model «endocytic system» to address these issues.
The work, led by Assistant Professor Wu Min, showed how a major endocytic pathway mediated by the protein clathrin, was found to commence with periodic traveling waves of clathrin, which were coupled temporally and spatially to downstream cortical actin waves.
Exosomes are a type of EV formed inside endocytic compartments, the multivesicular bodies (MVBs) and secreted in vitro upon fusion of these MVBs with the plasma membrane.
Using automated high - content superresolution imaging and quantitative data analysis, we determined how more than a dozen endocytic proteins are organised at the nanoscale.
Johannes L, Parton RG, Bassereau P, Mayor S (2015) Building endocytic pits without clathrin.
Our group has discovered two protein - protein interaction networks that sit at the heart of numerous endocytic and trafficking processes: the EH (Eps15 Homology) and monoUb networks (9 - 13).
We are performing screening experiments at the genomic and protein level to determine if endocytic proteins, or their regulators (e.g. kinases, E3 ligases, deubiquitinases), are aberrantly expressed in cancer.
We use tissue microarrays that contain normal and tumour tissue samples for high - throughput screenings and we have identified various endocytic proteins that are deregulated in cancer (16).
Seminar: Dr. Mara Duncan, «Endocytic Turn - Over Contributes to Cell Survival During Glucose Starvation».
However, we have recently discovered that, depending on the concentration of ligand, the EGFR may also be internalised via an alternative clathrin - independent / lipid raft - dependent endocytic route: non-clathrin endocytosis (NCE)(4).