Sentences with phrase «in human disease»

As computational biologists, they employ comparative genomic approaches to understand the evolution and function of protein families and their ultimate role in human disease.

This method is designed to discover gene function and validate candidate genomic sequences involved in human disease.

And just as in the human disease, the mice seemed to worsen over time.

His important discoveries have concerned the biochemical mechanisms and physiological regulation of protein breakdown in cells and the importance of this process in human disease.

Our computational biology research programme focuses on gene expression regulation and the mechanisms by which it can be disrupted in human diseases such as cancer.

For example, the causes of the incorrect distribution of the mitochondrial genome can be studied in some human diseases, such as muscular disorders or even specific forms of cancer.

The answer to this question may open new routes to target age - dependent alterations of stem cell activity in human disease.

My group studies how the resulting gene networks function and how they can be compromised in human disease.

Such environmental degradation, coupled with the growth in world population, is major causes behind the rapid increase in human diseases.

As epigenetic changes to genes can be profound and durable, it is entirely likely they are involved in human disease.

Due to their ability of self - renewal and differentiation into various tissues affected in each pathological condition, the development of these human disease - specific pluripotent stem cells provide new insights in pathological mechanisms implicated in human diseases for which, accessing homogenous affected tissues is often challenging.

Metabolism Director Dave Pagliarini's laboratory is driven to discover the biochemical underpinnings of mitochondrial dysfunction in human disease.

How do mutations in human disease genes, such as GATA4 and NOTCH1, and Elastin actually cause disease and how could anomalies be prevented even in the setting of mutations?

The role of this recycling and disposal system in human disease was not appreciated until Ohsumi and his colleagues» work in the 1990s revealed the yeast genes that orchestrate the process.

Learn more about this topic in our essay Opening Pandora's Bread Box: The Critical Role of Wheat Lectin in Human Disease.

Scientists from the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Center (CNIO), led by Nabil Djouder, have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mammalian / mechanistic Target of Rapamycin); a protein that is altered in human diseases such as cancer and diabetes, processes associated with aging, as well as in certain cardiovascular and neurodegenerative pathologies.

This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.

In January of 2009, I believe no matter who is elected, the first steps will be taken toward elucidating the role of stem cell research in human disease.

The ENCODE provides a resource for us to begin exploring possible regulatory roles of variants in human disease.

Small changes to DNA that were once considered innocuous enough to be ignored are proving to be important in human diseases, evolution and biotechnology

«Our study highlights the potential role of immune system cells in human diseases.»

To ensure that the proteins identified in the mouse were important to human psoriasis, her team then examined human psoriasis skin cells, known as keratinocytes, and human psoriasis skin tissue samples to confirm the increased presence of these proteins in human disease.

Join them for sessions on RNA Form and Function, RNA in Human Disease, and RNA - mediated Epigenetics as a part of the MAC - presented Issues in Depth symposia series, Gilded Strands: RNA Form, Function, and Role in Human Diseases.

Otherwise, the world will miss out on some pretty outlandish world - changing ideas — from autonomous vehicles to cancer - fighting checkpoint inhibitors to smartphones that can warn of an impending stroke to deep - learning machines that may solve some of the biggest mysteries in human disease.

Dr Vas Ponnambalam, Reader in Human Disease Biology in the University of Leeds» Faculty of Biological Sciences, said: «The ability to mount this two - pronged attack on cancerous growths is exciting.

The finding of dogs with a similar defect that developed similar symptoms was key to confirming that the BIN1 is, indeed, the culprit in the human disease, Laporte says.

The finding, reported in today's issue of the journal Cell, not only sheds light on this odd form of inheritance, but also lends support to a controversial theory about how such fibers may develop in human diseases.

Tiny particles bring deadly rain Nanobacteria have been implicated in human diseases from clogged arteries to ovarian cancer.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

«We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,» said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women's Hospital and Harvard Medical School in Boston, Mass. «Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.»

The researchers used the power of gene sequencing and clever computational methods to uncover the «source code» for human endothelial cells and learn how that code is disturbed in human disease.

The spheres represent mutations to Rumi that have been found in human diseases including cancers and Dowling - Degos disease (DDD).

Dr. Funari's research interests include developing new approaches for obtaining mycobiome profiles in human disease and the translation of next generation sequencing applications into the clinic and personalized medicine.

Despite the important role of prion - like domains in human diseases, a physiological function has remained enigmatic.

The molecular analysis of telomere length, telomerase levels, and activation of the Alternative Lengthening of Telomeres (ALT) pathway are currently being used as prognostic tools in human diseases.

The PHPN uses information in human disease networks in conjunction with network science tools to show clusters of related disorders sharing common genetic backgrounds.

By building this selective set of compounds and making it freely available, UNC - Chapel Hill and its partners are offering the scientific community a better understanding of the roles the kinome plays in human disease and the ability to collaborate on the discovery and advancement of new therapies.

Although CLP1 mutations have been linked to neuronal death and motor defects in mice, the role of CLP1 in human disease was not known until now.

Nicholas Katsanis of Johns Hopkins University in Baltimore, Maryland, and his colleagues, who have studied the role of cilia in human disease, wondered whether the organelles might be involved in higher order touch sensations.

Specifically, I am working on determining the mechanism by which an inflammatory protein, LIGHT, exacerbates disease in a mouse model and whether similar mechanisms are occurring in human disease.

Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35 - 37] making this an excellent parallel study for our currently reported data.

Career Goals: I want to pursue my career in scientific research involving host - pathogen interactions in human disease.

In my lab we are trying to identify genes involved in human disease by studying mutated DNA in mice.

As evidenced in human diseases, defects in DNA repair induce senescence and degeneration of nervous and endocrine / exocrine tissues.

«We now know that, in eczema, the mechanisms we found in mice are also operative in human disease,» says Kawakami.