Sentences with phrase «of growth factors»

Release of growth factors can occur as a result of surgery but the effects are of shorter duration.

These cells were encouraged to grow into cultured red blood cells using a cocktail of growth factors.

The local control also dramatically reduces the amount of growth factor required, an important cost consideration for manufacturing stem cells for therapeutic applications.

This is a result of increasing the satellite cells and stimulating the production of growth factors within the muscle tissue.

The results show that a relatively simple modification can greatly improve the clinical use of growth factors, by making them more efficient, cost - effective and safe.

Drug candidates currently in late stage clinical trials comprise of growth factors, which are traditional protein - based biological drugs associated with high costs, and some trials have been prematurely terminated.

The group also tested low - dose topical application of growth factors on diabetic mice, which are a common model for impaired wound healing.

This represents a small example of the hundreds of growth factors, proteins, and regenerative cells involved in the regenerative process that takes place when these cells are injected into a damaged joint.

Would that affect the results of fasting or would the fasting affect the results of the growth factor?

In fact, research suggests aerobic exercise boosts the release of growth factors in the brain that spurs the development of new nerve cell connections, especially in an area of the brain called the hippocampus.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

The significance of Fan and Tonks» research on FER is their discovery of how FER activates MET from below, i.e., in the absence of a growth factor docking at the receptor surface.

Dr. Kulkarni's lab also focuses on the role of growth factor signalling in the renewal and differentiation of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells with the aim of studying mechanisms that underlie differentiation into pancreatic endocrine cells.

The thought is that by injecting PRP into an injured area, an increased concentration of growth factors is then available to heal whatever damage is present.

M.Y.: The company is focused in large part on coming up with specific combinations of growth factor receptor inhibitors that have therapeutic efficacy in cancer.

Platelets also contain a remarkable array of growth factors involved in healing.

The treatments are often injections of growth factors from platelets, and lubricating fluid called hyaluronic acid.

UV radiation stimulates DNA mutations and causes local damage by several mechanisms and induces apoptosis through a production of growth factors from skin cells [26].

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.

In addition to providing a platform for studying the processes that regulate platelet production and related diseases, the researchers hope the platelets produced can be used as a source of growth factors for wound healing in regenerative medicine, including healing of ulcers and burns, and stimulation of bone tissue regeneration in dentistry and maxillofacial plastic surgery.

Changes in the presence of growth factors produced the teeth, which were consistent with those of archosaurs (the group that includes birds, nonavian dinosaurs, and crocodilians).

The plated cells were then dissociated and counted using a hemocytometer in order to express results as picograms or nanograms of growth factor produced per day per million cells.

«Research shows a cause of gastrointestinal symptoms in Type 1 diabetes: Excess of growth factor binding protein damages colon - maintaining stem cells.»

Clevers's mix of growth factors grows organoids consisting primarily of epithelial cells, so his technique doesn't work for the brain and other organs with few or no epithelial cells.

Despite their extensive therapeutic exploration, growth factors have been very limited in terms of clinical translation, mostly because drug formulations often fail to properly reflect the biological function of growth factors in wound healing.

A number of growth factors have been explored in pharmaceutical compounds to promote new blood vessel and bone formation, and even to trigger the generation of granulation tissue — a collagen - rich tissue that forms at the site of an injury.

«For the first time, we were able to demonstrate, in surgically resected metastases, that treatment with bevacizumab in combination with chemotherapy before metastasectomy also changes the clinical significance of the growth factors as potential biomarkers,» explains Stefan Stremitzer, one of the lead investigators from MedUni Vienna's Department of Surgery.

The researchers from the study group were able to show that upregulation of the growth factor VEGF - B, which is related to VEGF - A, in the primary tumor in the bowel prior to treatment was associated with a poorer prognosis, whereas upregulation of VEGF - B in the liver metastases after treatment was associated with a better prognosis.

For example, rats fed a high - fat, refined - sugar diet show reduced amounts of growth factors called neurotrophins in the brain, and scientists suspect that something similar happens to sugar - loving humans.

By focusing on newly elucidated biology of growth factor activation, Scholar Rock has developed insights which allow us to selectively target growth factors in the disease microenvironment — through the mechanism of supracellular activation.

-- The symptoms result from an excess of the growth factor PDGF, which prevents the temporary blood vessels of the foetal stage from disappearing, which in turn prevents normal development of blood vessels in the retina, says Karin Forsberg Nilsson, professor at the Department of Immunology, Genetics and Pathology at the Rudbeck Laboratory, who directed the study.

He is internationally recognized for his work on the control of cell growth and fate by the TGF -(beta) family of growth factors.

More recently, his work has focused on understanding regulation of growth factor shedding and autocrine signaling as a mechanism by which cells interpret their microenvironment.

Akt is a serine / threonine kinase that signals downstream of growth factor receptors and phosphoinositide - 3 kinase PI3K.

In this way, the implanted cells act as biological pumps for the local delivery of the growth factors in the brain.

Then feeder media were replaced by 50 μl of growth factor reduced Matrigel (BD Bioscience).

It then throws in plenty of growth factors (direct government funding, networking support, connections to customers, heavy promotion to outside investors, and relaxed regulations) and incubates them for years.

They then made flat sheets of a specific layer of gut tissue by exposing the stem cells for three days to a growth factor called activin A. Next, they made the sheets roll up into spheres and tubes by exposing them to a further pair of growth factors.

When the mother's and father's copies of the Igf2 gene are both mistakenly turned on, for example, the fetus gets a double dose of growth factor.

By analyzing the sequence of the growth factor, the scientists isolated a 22 - amino acid section that is responsible for the powerful binding of PIGF - 2 to extracellular matrix proteins.

A group led by Jeffrey A. Hubbell at EPFL has found a way to vastly improve the efficiency of growth factors, while keeping their usage at low doses.

Thus, future strategies for repairing the central nervous system might involve concocting even more potent mixtures of growth factors, like Sofroniew's «carrot,» that could be continuously infused or implanted near a patient's injury.

Due to close similarities of the growth factor in humans and dogs, also a treatment of canine breast tumours seems possible.

«Development of growth factor - free tissue adhesive porous films singularly capable of promoting angiogenesis.»

These include lipid lowering; protection from oxidative stress and inflammation; modification of growth factors that can promote cancer; inhibition of nutrient sensing pathways by amino acid restriction and gut microbiota - mediated production of metabolites.

The researchers also have yet to determine the specific recipe of growth factors that would coax stem cells to create other types of sensory interneurons.

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.