Sentences with phrase «tumor suppressor»
A "tumor suppressor" is a type of gene that helps prevent the development of cancer. These genes protect our cells from growing and dividing too much or too quickly, which could lead to the formation of tumors. They act as brakes on cell growth and repair damaged DNA, keeping our cells healthy and preventing them from becoming cancerous. Full definition
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
massgenomics.org
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
«HOXA5 protein acts as tumor suppressor in breast cancer, lab cell study shows.»
In the first test using KnIT, the team sought to identify new protein kinases that phosphorylate (or turn on) the protein tumor suppressor p53.
The scientists are planning further study of HOXA5's role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known tumor suppressor protein p53.
After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.
Researchers have identified a protein that activates the well - known tumor suppressor gene p53 to prevent the division of cells that have damaged DNA.
Mechanistic study of transcriptional regulation of stress - responsive Sestrin genes by tumor suppressor p53
These data confirm that LARP7 protein levels are also reduced during breast cancer progression, and thus suggest that LARP7 may play a potential tumor suppressor role in breast cancer.
Yeddula N, Xia Y Ke E, Beumer J, Verma IM (2015) Screening for Tumor Suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRAS in promoting lung adenocarcinoma.
It was hypothesized that BAP1 tumor suppressor activity could reside, at least in part, in stabilizing proteins through its poly - deubiquitinase activity.
Dr. Kemp has studied the genetic and molecular basis of cancer for more than 25 years and has been internationally recognized for his pioneering research on tumor suppressor genes.
«Researchers identify «synthetic essentiality» as novel approach for locating cancer therapy targets: Initial focus on prostate cancer points to CHD1 protein as one potential treatment site for cancers lacking key tumor suppressor genes.»
In a retrospective case study involving published data on p53, an important tumor suppressor protein, the team showed that this new resource called the Knowledge Integration Toolkit (KnIT) is an important first step in that direction, accurately predicting the existence of proteins that modify p53 — proteins that were subsequently found to do just that.
His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.
Moreover, the C - terminal region of LARP7, which is essential for the sequestration of P - TEFb in 7SK snRNP, is required for LARP7's suppression of breast cancer survival and is frequently deleted in human gastric cancer (Mori et al., 2002), suggesting that LARP7 may be a potential tumor suppressor in a broad range of human carcinomas.
Glucosinolates may help prevent cancer by helping to remove potential carcinogens from the body and increasing your body's defense against cancer with tumor suppressor proteins.
June 2013 — PTEN is one of the body's many tumor suppressor genes.
LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...
«These novel algorithms of identifying tumor suppressors and oncogenes nicely provide an explanation of how aneuploidies evolve in cancer cells, and the realization that subtle changes in the activity of many different genes at the same time can contribute to tumorigenesis is an exciting and intriguing hypothesis.»
The four mutations out of 20,312 reads found in DEC1 (a putative tumor suppressor [46]-RRB- and the single mutation out of 21,139 reads found in an extragenic region of chromosome 11 could be due to PCR and sequencing errors or to very low levels (< 0.02 %) of ZFN - mediated cleavage events.
The funding from the Breast Cancer Research Foundation will help Dr. Carpizo build upon previous research from his laboratory examining a drug compound that restores tumor suppressor function of p53, with an aim of providing a foundation for the development of a new type of anti-cancer drug.
In conclusion, our study characterizes the biological function of DDX3 as a putative candidate tumor suppressor gene, at least in HCC and cutaneous SCC.
«Combination therapy strengthens T cells in melanoma pre-clinical study: Findings have implications for treating tumors lacking tumor suppressor gene PTEN.»
On the other hand, aberrant expression of miR - 7 was observed in glioblastomas, and it has been characterized as a putative tumor suppressor by targeting EGFR and AKT (23, 24).
Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.
A UNC Lineberger Comprehensive Cancer Center discovery of just how a certain tumor suppressor molecule works to prevent tumor growth could lead to a personalized treatment approach for colon cancer.
Identification of endonuclease domain - containing 1 as a novel tumor suppressor in prostate cancer.
Cold Spring Harbor, NY — The gene called PTEN is one of the most important of the body's natural tumor suppressors.
«This study provided a conceptual framework for the discovery of «traceable» targets in cancers harboring specific tumor suppressor deficiencies.»
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in...
The long - term goals of my laboratory are to understand how alterations in the RB1 and TP53 tumor suppressor gene regulatory networks cause cancer.
«Upending a cancer dogma: Cyclin D, long believed to promote cancer, actually activates tumor suppressor.»
But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.
Researchers have finally been able to make the charges stick against a long - suspected tumor suppressor gene.
Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.
«PTEN is one of the most frequently deleted tumor suppressor genes in cancer, so if we can take our finding to the next level and develop a therapeutic around it, it could have wide utility,» said Furnari, who is also a Professor of Pathology at the University of California, San Diego.
A cluster of highly potent tumor suppressors was more likely to mean chromosome deletion than a cluster of weak suppressors.
«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important tumor suppressors like p53.»
They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells -LRB-
Jimenez - Garcia L, Herranz S, Higueras MA, Luque A, Hortelano S. Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization.
Together, our results show that DDX3 exerts tumor suppressor functions, including growth inhibition and transcriptional modulation of the promoter activity of p21waf1 / cip1, and is inactivated through deregulated expression or nuclear exclusion in tumor cells.
This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb).
Because DDX3 exhibits tumor suppressor functions, it is interesting to know whether DDX3 is inactivated in tumor cells by alteration of gene expression.