Sentences with word «apolipoprotein»

Understanding the Role of Apolipoprotein E in Microglia Edoardo Marcora, PhD Icahn School of Medicine at Mount Sinai (New York, NY)

A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late - life moderated by the environment

Using a small fragment of apolipoprotein B as a guide, Brian Spencer, a postdoctoral fellow in the Verma lab and the study's lead author, successfully shepherded the enzyme glucocerebrosidase into the brains of adult mice.

A gene called Apolipoprotein E (ApoE) appears to be a risk factor for the late - onset form of AD.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

Just realized that since virgin olive oil caused an increase in apolipoprotein B while walnuts & almonds caused a decrease, the whole food does have a more beneficial effect on LDL - p than the refined oil in this case, correct?

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.

(Apolipoprotein E-ε4 is the top risk gene for Alzheimer's.)

The relations between fat from cheese and apo (a), between fat from ice cream and the insulin sensitivity index, and between fat from butter and BMI, HDL cholesterol, LDL - HDL ratio, and apolipoprotein A-I also remained significant after adjustment for physical activity.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

People with one copy of the variant, called apolipoprotein E-e4 (APOE e4), have a 29 % lifetime risk of developing Alzheimer's disease, while people who don't have it have a 9 % risk.

Low - density lipoprotein (LDL) receptors, which can be found on the surface of most cells including endothelial cells, for example, shuttle large molecules such as apolipoprotein B across the blood - brain barrier.

«Approximately 15 percent of the human population carries apolipoprotein APOE4.

Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.

Campbell is justified in noting the link between apolipoprotein B (apo - B) and cardiovascular disease in the China Study data, a connection widely recognized by the medical community today.

At apolipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for MI.

The connection involves apolipoprotein E (apoE), a protein that helps to transport cholesterol through the body.

Long - term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics — Ida Rune — Scientific Reports

They tested this idea by administering the primary component of HDL, a protein called apolipoprotein AI, to their mice.

Contrasting the results of the current study, other studies have shown a reduction in HDL - cholesterol and apolipoprotein A-1 when saturated fat has been replaced with carbs (8, 9).

Dr. Mahley, along with Gladstone Investigator Yadong Huang, MD, PhD, will use the funding to identify new chemical compounds that can target apolipoprotein E4 (apoE4)-- the strongest genetic risk factor for developing Alzheimer's.

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C - III (ApoC - III) levels.

ROC curve analysis: an example showing the relationships among serum lipid and apolipoprotein concentrations in identifying patients with coronary artery disease

In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E.

In the absence of serum, the cells secrete apolipoprotein E, but not cholesterol.

In addition, this proportion was cut back by 12 % if smoking was eliminated; 9 % for cardiac (heart) causes, 4 % for diabetes, 6 % for alcohol intake, 6 % for stress, and 27 % for lipids (the study used apolipoproteins, which was found to be a better predictor of stroke than total cholesterol).

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

The researchers found that apolipoproteins APOE2, APOE3 and APOE4 have different abilities to transfer lipids from neurons to glia and hence differ in their ability to mediate the accumulation of lipid droplets.

The paper «Gain of toxic Apolipoprotein E4 effects in Human iPSC - Derived Neurons Is Ameliorated by a Small - Molecule Structure Corrector» was published by Nature Medicine on April 9, 2018.

Apolipoprotein EWIKIMEDIA, PROTEIN DATA BANK / J.

Abbreviations: LDLR = LDL receptor; APOB / A1 = apolipoprotein B - 100 / A1; PCSK9 = proprotein convertase subtilisin / kexin type 9; SREBP - 1 / 2 = sterol regulatory element - binding protein 1/2; LPL = lipoprotein lipase; FATP2 / 4/5 = fatty acid transporter protein 2 / 4/5; FASN = fatty acid synthase; SCD5 = stearoyl - CoA desaturase 5; ACADL = acyl - CoA dehydrogenase; L - FABP = liver fatty acid - binding protein; and CPT1A = carnitine O - palmitoyltransferase 1.

APOA5 is a recently discovered apolipoprotein involved primarily with triglyceride (TG) metabolism disorder.

Additional studies indicate that impaired Apolipoprotein E function, which also increases oxidative stress and is also associated with AD, potentiates the deleterious activity of PS - 1.

For example, we identified processes that can explain why apolipoprotein (apo) E4 is the main genetic risk factor for Alzheimer's disease and also worsens outcome after traumatic brain injury.

In 1999, he was named an Alexander Hollaender Distinguished Fellow where he identified a novel apolipoprotein (ApoA5) involved in human and mouse triglyceride metabolism.