Sentences with word «chondrocyte»

The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.

Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. «Photoencapsulation of chondrocytes in poly (ethylene oxide)- based semi - interpenetrating networks.»

Proteomics of chondrocytes with special reference to phosphorylation changes of proteins in stretched human chondrosarcoma cells.

Effects of oxygen on human chondrocyte zonal phenotype.

For instance, to make a rod with collagen fibers aligned along its length (like a tendon) they cultured chondrocyte cells in a dog bone - shaped mold with loops on either end.

Cartilage - derived chondrocytes can be used for cartilage repair, but the expanded cells quickly lose their cartilage - specific characteristics.

As a typical child's bones elongate, cartilage cells called chondrocytes mature and then die, allowing hard, bony material to supplant them.

The team discovered that a certain subset of cartilage - making cells, known as chondrocytes, replicate themselves, make other bone cells and drive bone growth — findings that could lead to new treatments for children with facial deformities who normally have to wait until adulthood for corrective surgery.

By contrast, the R206H ACVR1 mutant only slightly enhances the expression of initial and early chondrogenesis markers (collagen type II and aggrecan), consistent with a milder stimulatory effect of the FOP ACVR1 mutation on chondrocyte differentiation.

The means to enhance the production of cartilage - specific extracellular matrix is needed for cell - based tissue engineering applications, since cultured chondrocytes quickly lose their cartilage - specific phenotype.

Previously, it has been suggested that S100A1 and S100B proteins can act as markers of chondrocyte differentiation status, although the concept is still not commonly adopted so far.

This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).

The cellular stretching relates to stresses, which are directed to chondrocytes during the mechanical load.

When this particular type of Sox9 binding occurs at multiple sites along the DNA, it turns on the genes that make the cells into chondrocytes.

This finding offers new evidence of the applicability of S100A1 and S100B as markers of chondrocyte phenotype,» says Juha Piltti.

Dynamic compression improves biosynthesis of human zonal chondrocytes from osteoarthritis patients.

Autologous bone marrow - derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study.

p38 kinase regulates nitric oxide - induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B - dependent transcription and stabilization by serine 15 phosphorylation.

Cartilage regeneration using zonal chondrocyte subpopulations: A promising approach or an overcomplicated strategy?

Chondrocytes differentiated from TD - iPSC produced less cartilage than those from WT - iPSC and also had a lower proliferation rate and greater apoptosis, properties that were attributed to a gain of function by the mutated FGFR3.

Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: «We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors.

Furthermore, organ cultured cartilage from ACH mice treated with statin resulted in increased expression of the aforementioned three genes and also in Runx2 and Col10a1, which indicated that statin stimulated both the differentiation and maturation of ACH mouse chondrocytes.

This could let synthetic biologists generate tissues on demand, such as insulin - producing β cells, or cartilage - producing chondrocytes.

SOX9 and its co-factors SOX5 and SOX6 form a trio that is required for chondrocyte differentiation and thereby for cartilage formation and maintenance.

Kenji demonstrated that SOXC proteins fulfill this function primarily through actions in perichondrium cells, but also through actions in growth plate chondrocytes.

New SOX chondrogenic trio projects in the laboratory are addressing the roles of the proteins in chondrogenic precursor cells and in adult articular chondrocytes.

These are composed of specialized cells that are called chondrocytes which function in the maintenance of the integrity of the cartilage.

Research Paper MicroRNA - 193b - 3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3 Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao Theranostics 2018; 8 (10): 2862 - 2883.

According to the research team, the relevance of their findings to human disease was validated using chondrocytes isolated from arthritic patients.

Downregulation of microRNA - 448 inhibits IL - 1ß - induced cartilage degradation in human chondrocytes via upregulation of matrilin - 3.

Preliminary data from in vivo testing over 60 days show the combination does indeed encourage chondrocyte and cartilage production.

Thomas Webster, an associate engineering professor at Brown University, and Brown researcher Dongwoo Khang, along with Grace Park, a research scientist (and one of Webster's former PhD students) at Becton, Dickinson and Company, a Franklin Lakes, N.J. — medical technology firm, say they grew cartilage cells by placing chondrocytes (cartilage - forming cells) and carbon nanotubes together on a polycarbonate urethane surface.

According to Mr. Goldstein's abstract, «The cells survived the 3D printing process, were able to continue dividing, and produced the extracellular matrix expected of tracheal chondrocytes.»

However, the fact that bone still heals itself even without chondrocytes caused intense debate among researchers.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

The study is the first, say its authors, to provide evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role — keeping on hand a steady number of healthy chondrocytes, the cells that make and sustain cartilage.

Alsberg and colleagues mixed bovine chondrocytes, which fabricate cartilage, and bone - building osteoblasts from rats with a gelatinous matrix that contained a molecular growth signal.

Cronstein and his team also found that levels of adenosine A2A receptors went up on rat chondrocytes when osteoarthritis was present, in what the researchers say was a «failed attempt» to compensate for the loss of adenosine from the energy - processing (metabolic) changes underlying the inflammation.

Long - term effects of hydrogel properties on human chondrocyte behavior.

Effect of preculture and loading on expression of matrix molecules, matrix metalloproteinases, and cytokines by expanded osteoarthritic chondrocytes.

Chondrocyte redifferentiation and construct mechanical property development in single - component photocrosslinkable hydrogels.

Thus, SOX9 expression in chondrocytes involves various transcriptional modules regulated by SOX9 itself and by other factors.

In the study analyzing its effects on arthritis, 15d - PGJ2 mediated shear - induced chondrocyte apoptosis via protein kinase A (PKA)- dependent regulation of PLK1.

Based on previous protocols [5, 6] they have now created a 3D protocol for chondrogenic lineage differentiation via the generation of a putative chondrogenic progenitor cell population, and have found that using this protocol C - iPSCs can be readily differentiated into cartilage in a manner comparable to that of mature chondrocytes [7].

Together they studied the efficacy of chondrocyte implantion to treat osteoarthritis and osteochondritis dissecans (OCD) lesions in horses.