Sentences with phrase «in cancer cells»

These genes and proteins are found in cancer cells or in cells related to cancer growth, like blood vessel cells.

The analysis revealed that several functions were associated with more or fewer genes in cancer cells than in healthy cells, but not because of changes in the expression of these genes.

A novel computational analysis of the resulting datasets produced personalized diagrams of signaling pathways in the cancer cells of each patient, the details of which suggest potential targets for therapy.

More than 90 percent of genetic changes in cancer cells involve the loss or gain of a single copy of a gene, rather than a mutation.

This is critical as iron can be a key ingredient in cancer cell growth.

Looking at the long - term prognosis, considering the many mutations in a cancer cell, no single drug is going to stop a tumor from growing.

We learn which specific genes are expressed in cancer cells and how a patient may respond to different therapies, so that we can select the most appropriate targeted treatment for the particular cancer.

This results in cancer cells needing to adapt to low oxygen environment.

The drug is formed from groups of molecules attached to a platinum atom, creating a compound that reacts with DNA in cancer cells.

It has been shown that the oxygen levels in cancer cells largely determine how aggressive the cancer is at spreading.

By blocking its expression in cancer cells, doctors may be able to let nature take its course on these out - of - control cells.

Of course, if there is too much oxygen in the cancer cells, the cancer cells die.

Such precise regulation of the cell cycle is lost in cancer cells.

The scientists also studied the role this pathway might play in cancer cells.

Now researchers have discovered a mutation that fixes a key protein that's often broken in cancer cells.

Recently, however, the phenomenon has also been observed in cancer cells and has even been connected with brain development.

One of the main characteristics we see in cancer cells is that they lose their ability to produce energy from oxygen.

The virus is engineered to grow in cancer cells, destroy these tumors, and then spread to other cancer sites.

Once we figure that out, this may serve as a paradigm to understand whether the same thing is happening in cancer cells.

These tools have also been used to study epigenetic changes associated with cancer, mechanisms of DNA damage and repair, and gene regulation in cancer cells.

Does the biological clock in cancer cells influence tumor growth?

Her lab also studies how different proteins (and their mutations) interact in cancer cells.

It is effective in cancer cell samples and cell lines resistant to conventional therapies.

Historically, these tests have been conducted in cancer cells, which often don't match the biology of human brain cells.

A number of the mechanisms which help prevent abnormal cell growth are avoided in cancer cells.

Basically, without blood sugar present, research has shown that the «power grid» goes dark in cancer cells.

With today's molecular knowledge of altered metabolic pathways in cancer cells we are making real advances in progressing cancer treatments.

The less oxygen in the cancer cells, the more aggressive the cancer cells are at spreading.

* The fact is that because cancer cells reproduce more rapidly than any other cell in the body, mutations occur in cancer cells in far greater numbers.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

The new study published in Cancer Cell by Sarris et al. shows that Smyd3 expression correlates with poor prognosis of human hepatocellular carcinoma.

Astrocytes upregulate survival proteins in cancer cells which protect those cells against chemotherapeutic agents such as temozolamide.

Indeed, experiments in living tissue showed that inhibiting CKB activity in cancer cells strongly suppressed metastatic growth in the liver, and the administration of miR - 483 and miR - 551 to mice with metastatic liver cancer decreased colonization by 80 percent.

«The attention has mostly been on inflammation and diabetes but there has always been an interest in cancer, and we were the first to show this mechanism in any cancer cell at all.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

This CK2 inhibitor restored Ikaros function and resulted in a strong therapeutic effect in cancer cells from B - ALL patients.

It also provides a clue to understand why carbohydrate restriction can metabolically inhibit cancer growth, (though not simply because glucose in the blood is reduced; rather because low insulin and high ketone bodies interfere with glucose metabolism in cancer cells!!)

The study, published in Nature Communications, examined the changes that occur in cancer cells as they break away from tumours in cell cultures, zebrafish and mice.

In other scenarios, such as in cancer cells, FOX01 promotes cell death and interferes with the cell reproduction, two actions that would seem to be detrimental to healing.

The research team found that the protein RYBP prevents DNA repair in cancer cells, including breast cancer.

More recent work in our laboratory focuses on elucidating signaling pathways that mediate the activities of Eph receptors in cancer cells.

«The advanced nano - focussed x-ray beam at ESRF has not only allowed us to locate the site of action of our novel Organo - Osmium FY26 candidate drug in cancer cells at unprecedented resolution, but also study the movement of natural metals such as zinc and calcium in cells.

«Preliminary results show that BCAR4 is only active in the cancer cells and not in normal adult tissues.

Curcumin's anticancer effect is attributed to its ability to induce apoptosis in cancer cells without cytotoxic effects on healthy cells.

We are testing the idea that a drug that inhibits BPTF might have the same effect in cancer cells as in stem cells - it could cause them to differentiate and then die.»

Drs. Tamanoi and Zink joined their diverse teams and collaborated with Dr. Jean - Olivier Durand at University of Montpellier, France to develop a new type of microscopic particles (nanoparticles) that can absorb energy from tissue - penetrating light that releases drugs in cancer cells.

The complaint says that Thompson was at first forthcoming about the possibility that he would form a company based on his work in cancer cell metabolism.

«We think that these genes, which are normally only expressed in the placenta to facilitate invasion, are becoming reactivated in cancer cells and supporting invasion in this context too,» she says.

The virus initiated apoptosis — natural cell death — in cancer cells without affecting healthy cells.

Then, they compared the number of genes inferred to perform each function in cancer cells relative to healthy cells.