Sentences with phrase «wild type»

«Early during pregnancy, if the mother is infected, there is significant impact on the fetus, even in wild type mice,» she noted.

Numbers represent percent increases relative to wild type mice and were calculated from the data shown in Table 1.

As shown in Table 1, all four lines exhibited significant increases in muscle weights compared to wild type control mice.

For example, vemurafenib is more effective in melanoma containing BRAFV600E mutation, than melanoma cells with wild type BRAF protein.

These are low passage wild type parental clones suitable for a single electroporation and germline transmission.

The morphometric analysis confirms that there is more CARS positive signal and therefore most likely more fat in W01A8.1 null embryos (despite lower threshold used for analysis of wild type embryos) and less CARS positive signal (and less fat) in adult tissues of W01A8.1 null animals compared to controls.

Feng said that breakage patterns at different subsets of the hydroxyurea - induced genes were also observed in wild type cells and checkpoint - deficient mutant cells with unstable replication forks.

The researchers added that the new compound was designed to reduce toxicity and to improve drug resistance by treating melanoma cells containing wild type BRAF as well as mutated BRAF.

a, c) McGill APP transgenic rats exhibited lower recognition memory indices than wild type littermates at a) pre-plaque (3 months) and c) post-plaque (13 months) stages.

However, I did obtain a number of female Z116A transgenic mice that were heterozygous for the myostatin mutation, and as shown in Table 1 and Figure 2a, these mice exhibited further increases in muscle weights compared to Z116A mice that were wild type for myostatin.

That way, they reasoned, those genes that are normally repressed by Fur in the presence of environmental iron would be produced in large quantities by the mutant, but not by wild type C. difficile, which would help them identify the iron - importing proteins.

A matched wild type is included.

These are the same T cell genes inhibited by digoxin, and since replication of integrated HIV - 1 requires transcription of nearby genes, this provides an explanation for why wild type HIV - 1 is more susceptible to digoxin: digoxin represses the genes that the virus more frequently targets for integration.

Wild type on left, nac016 mutants on right.

In the absence of HIV infection, the cxcr4 disruption frequency remained stable over time in four independent experiments testing four different ccr5 wild type donors as measured by deep sequencing.

Wild type C. baccatum.

In wild type plants, for example, the root tip immediately starts to grow back in the direction of the gravitational stimulus — this is clearly visible already after six hours (upper plant, yellow arrow).

«Recent data have described a correlation between the levels of activated Notch1 and poor prognosis in a cohort of NSCLC patients, but only in patients with wild type p53,» a group that they wrote represents about half of all NSCLC patients.

To determine whether ZFN - mediated disruption of cxcr4 indeed protects CD4 + T cells from an in vitro HIV challenge, human CD4 + T cells from three different ccr5 wild type donors were stimulated and transduced with AdX4 - ZFNs or an AdR5 - ZFNs control.

These are high passage wild type parental clones suitable for DNA extraction, control purposes, but not for germline transmission.

Wild type alleles in ancient samples are represented by yellow dots and derived alleles by red dots.

Wild type Arabidopsis flowers develop four petals.

In parallel, we will investigate the accumulation and function of transcription coactivators, including the Mediator and different histone modifying enzymes, on endogenous sestrin genes in mouse cells expressing wild type versus serine18 mutant p53.

Wild type chili pepper with piercing pungency which comes down quite quickly.

Guice is just a straight forward run wild type player.

He bred and raised 16 varieties of pigeons, trying to show that the fancy types preferred by breeders had developed from only a few ancestral wild types.

They showed that the flies missing Rh7 took significantly longer to adjust than the normal, wild type flies.

Activated, wild type B cells from female mice tightly localize Xist RNA at their inactive X chromosomes (left), whereas Xist RNA becomes dispersed throughout the entire nucleus when YY1 is deleted (right).

The cocoa tree, Theobroma cocoa, originates from the upper Amazon basin, where wild types of the plant are vanishing as the forests are felled.

«An Important finding from this study is those patients with tumours which were multiple wild type — that means no mutation in the KRAS, NRAS, BRAF and PIK3CA genes, were most likely to be EGFR - dependent; in fact, these patients had significantly better progression - free survival when treated with cetuximab and chemotherapy than when treated with chemotherapy alone, hazard ratio 0.56, which was significant (p = 0.025).

In the study, published in Cell Reports, the University of Kentucky's Vivek Rangnekar and his colleagues activated wild type p53 in normal cells to trigger cell death in the p53 - deficient cancer cells.

This chemical screen showed that a compound known as digoxin — a plant - derived cardiac toxin often used to treat various heart conditions — inhibited wild type HIV - 1 more than the mutated strain.

«With normal, wild type bacteria, the mice would die even if you treated them with the antibiotics,» Nguyen said in the podcast.

«They also suggest that interactions between oncologic kinases and SYK or other wild type enzymes may contribute to resistance of kinase inhibitors more broadly.»

We find that embryonic hemocytes both recognise and phagocytose injected wild type, non-pathogenic E. coli in a Dscam independent manner, proving that embryonic hemocytes are phagocytically competent.

As seen in ccr5 wild type CD4 + T cells, exponential cell growth was preserved in cultures treated with X4 - ZFNs compared to control cultures that were untransduced or treated with R5 - ZFNs (Figure 5A).

«We also think, with this compound and this type of approach, if it goes further, we should be able to delay, or overcome resistance because it not only targets BRAF mutant melanoma cells, but also BRAF wild type melanoma cells.»

By tagging wild type and mutant constructs of ATP7B with Green Fluorescent Protein (GFP), we have followed the copper - dependent dynamics of the protein in polarized WIF - B cells.

This cell death is induced by many rough attenuated Brucella strains, including Brucella cattle vaccine strain RB51, B. abortus wboA mutant VTRA1, and B. suis wboA mutant VTRS1.This cell death is prevented by wild type virulent Brucella in infected macrophages, but not in dendritic cells.

We investigated the acquisition of peak responding in R6 / 2 mouse model of Huntington's disease and their corresponding wild type controls.