Sentences with phrase «candidate genes»
Candidate genes refer to specific genes that are believed to be associated with a certain trait or condition. These genes are identified based on previous research or observations, suggesting their potential role in causing or influencing the trait or condition in question. Full definition
This study presents several candidate genes for further studies of the regeneration process.
scilifelab.se
Further evidence of the limited role of candidate genes in relation to infant — mother attachment outcomes.
Another key element concerns the involvement of several identified candidate genes in the immune response to viruses, thus highlighting the importance of viral infections in the risk of asthma.
We then use a range of techniques to validate the role of the novel candidate genes in the development of cancer.
In this study, the researchers looked for signals in the evolutionary data to steer them toward new candidate genes.
Our goal is to find candidate genes affecting primary hypertension.
The researchers then identified children, among other families, who carried the single candidate gene.
During these years, my team discovered several promising candidate genes for schizophrenia and smoking addiction.
They found that the associated regions contained numerous candidate genes, among them genes known to affect ear function, language development, memory, bird song and the brain's reward mechanism.
Studies have been extended by investigating associations with other candidate genes.
We use it for candidate gene discovery in all of our major vegetable crops.
Taken together, the emerging studies of adolescents focused on logical candidate genes offer fine templates for genetic research on adolescent substance use.
An active international research has been carried out for several years in order to identify candidate genes which explain the origin and development of the disease.
Furthermore, high - resolution analysis of cytosine methylation in primary and transformed cells has found less aberrant methylation of CpG island promoters in transformed cells than had been previously hypothesized based on candidate gene studies [58].
We therefore re-checked the CDH2 candidate gene from the data, leaving out all control dogs receiving vitamins and minerals; however, again no association was found.
Unlike studies of candidate genes involved in sex differentiation, the positional cloning approach is candidate - blind, so it is intriguing that the region we identified as causing a sex specific increase in wing size (ws1) also contains the 5 ′ UTR of the sex - signaling gene doublesex.
«Novel autism candidate genes identified.»
Right now, the UPV / EHU researchers are in the phase involving the validation of candidate genes by analyzing their expression levels in biopsies of melanoma and nevi (growths of non-malignant melanocytes).
Admittedly, for many tumor types, the most frequently mutated genes had already been identified by candidate gene sequencing, copy number analysis, and other approaches.
We found differential methylation in 123 sites (q < 0.15) representing 50 T2D candidate genes including IRS1, PPARG, KCNQ1, and TCF7L2 (Supplementary Table 14 and Fig. 2K).
In particular, the care taken to address issues of biological plausibility and the attempts to link specific aspects of the clinical phenotype to different genes is notable and provides a platform for examining the role of candidate genes on adolescent substance use.
Perform phenotypic profiling in primary human cells to identify and characterize candidate genes with therapeutic potential,
By combining those factors, Phevor identifies an undiagnosed disease or the most likely candidate gene mutation for causing a disease.
Chromosomal regions harboring candidate genes were evaluated for SNP haplotypes with frequencies of 1.0 in the CMS cases and between 0.14 and 0.50 in the controls.
Therefore, better analytical approaches that enrich the list of candidate genes with authentic cancer - associated «driver» genes are needed.
«With the first families, we had no idea what gene might be causing this disorder, so we did a genome analysis and a good candidate gene screen came in with CLP1,» said Karaca.
In the light of the latest meta - analyses questioning the 5 - HTTLPR main effects [113] and 5 - HTTLPR by stressful environment interaction effects [114], these initial investigations of genetic and gene - environment interaction effects on attachment need to be confirmed by larger studies, possibly including multiple polymorphisms of multiple candidate genes.
«IL - 33 stands as one of the strongest candidate genes for asthma to date,» Barnes says.
University of Illinois researchers have identified candidate genes controlling the accumulation of phenolic compounds in broccoli.
The new knowledge and target candidate genes resulted from such unbiased study are ultimately important for researchers to understand the fundamental nature of stem cell proliferation and differentiation.»
Graduate student Yu - Hsiang Tu then tested candidate genes one - by - one until he found one that produced a proton - conducting protein when introduced into cells that did not have any proton - conducting channels.
The new approach enables the researchers to mutate different candidate genes in hundreds of thousands of T cells from healthy volunteers, expose these mutant cells to the HIV virus, then screen through the cells to find which mutations were able to prevent infection.
Applying our method to the public domain Parkinson's disease data set leads to a significant increase in finding candidate genes known to be associated with the Parkinson's disease.
Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.
To complement ongoing positional cloning efforts, we have undertaken a large - scale candidate gene association study.
The second update was received on the 9th December when the BTHG was informed that «the work of analysing the genomes across all the dogs in the project to identify and check out possible candidate genes was progressing satisfactorily».
Serotonergic receptor genes have been considered candidate genes in many studies looking at panic disorders in humans, but results have been inconsistent.
Genomic regions known to harbor CMS candidate genes were screened for case allele frequencies of 1.0 and control allele frequencies of between 0.14 and 0.50.
«These findings illustrate how resurrection plants manipulate sugar metabolism to promote desiccation tolerance and may provide candidate genes that are potentially useful for the development of stress tolerant crops.»