Sentences with phrase «cell signaling pathways»

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

This includes chronic inflammation, DNA damage and disruption of cell signaling pathways.

These physical effects lead to cell signaling pathways for enhanced cell survival.

She developed a digital game to help students master cell signaling pathways, with the aid of lots of books and advice from game designers.

The researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways.

Hicks discovered that a specific cell signaling pathway called TGF Beta needs to be turned off to enable generation of skeletal muscle fibers that contain the proteins that help muscles contract.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

«We think the way this stem cell signaling pathway works is fundamental to all plants,» Jackson says.

«This antibody microarray allowed us to find a number of new cell signalling pathways that were activated or suppressed by an HCV infection,» Professor Doerig said.

It was also discovered that it maintains specific cell signalling pathways necessary for nerve cell survival.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

For instance, overexpressing genes that reshape the cytoskeleton (the cell's structural scaffolding) resulted in similar signatures, as did overexpressing genes within or related to particular cell signaling pathways.

Dr. Rebecca Vega Thurber received her doctorate in 2005 from Stanford University where she studied developmental cell signaling pathways in sea urchin larvae.

Interferons and progesterone for establishment and maintenance of pregnancy: Interactions among novel cell signaling pathways

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

Luteolin restricted the IGF - I growth stimulatory effect and the researchers discovered that luteolin affected IGF - I activated cell signaling pathways in cancer.

Research now reveals that luteolin has the ability to restrict the activity of the IGF and PI3K cell signaling pathways necessary for the development of cancer found in cancer cells of the colon.

Research suggests the answer lies in specific enzymes and cell signaling pathways stimulated by all - out effort.

ROS are important signaling molecules for a number of different cell signaling pathways, particularly those associated with stress - response, and we are stress - response machines.

Another surprising finding was the direct link between Notch and genes involved in other B cell signaling pathways.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

Examining mechanisms of sensitizing IBC to radiation including targeting stem cell signaling pathways, signaling, and epithelial mesenchymal transition (EMT) in IBC cells and tumor models

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

The team, led by Sérgio Dias, had previously shown that leukemic cells activate certain molecular signals, namely a cell signalling pathway controlled by the Endothelial Vascular Growth Factor (VEGF), which allow cancer cells to survive despite chemotherapy.

They found that these genetic differences were tied to several important developmental and cell signaling pathways.

She says her team must now investigate the cell signaling pathways involving the NOD proteins to precisely pin down how NOD1 and NOD2 interact with CMV and the other systems within our cells.

A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

One finding was that a cell signal pathway called Wingless and its central signal molecule, beta - catenin, can regulate the production of MGMT in the tumour cell.

Stat3 is a protein that regulates a cell signaling pathway critical to tumor growth and development.

Cell signaling pathways are a defined series of interactions between proteins that govern biological functions, initiated by receptors on the surface of cells.

B cell signaling pathways are the current targets of several therapies used to treat B cell malignancies such as CLL.

In cancer, cell signaling pathways are the critical chain of events that can either quash or quicken disease progression.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

Dr. Joyal has over 20 years of drug discovery experience with expertise in cell and molecular biology, particularly in the areas of receptor biology, cell signaling pathways, and assay development.

To prevent this from happening patients are treated with a second compound that stops this cell signaling pathway from being unintentionally activated.

The results, which were published and highlighted in Molecular Systems Biology, give researchers a more complete view of cell signaling pathways.

Using imaging techniques, the cell signaling pathway can be investigated in detail to target areas that could prevent cancer from developing.

Luteolin decreased activation of the cell signaling pathways Akt, PI3K, and CDC25c and ERK1 / 2 that are dependent on IGF - I.

While some amount of omega - 6 s are important for membrane structure and cell signalling pathways (Institute of Medicine 2005), consuming too much can interfere with neurological development through inhibition of omega - 3 PUFA metabolism and availability (Novak et al. 2008).