Sentences with word «isoform»

Identification and expression of novel isoforms of human stromal cell - derived factor 1.

«We found that the protein isoforms expressed in African Americans with prostate cancer do not always respond to targeted therapies, whereas these drugs were found to be effective in European Americans with prostate cancer and do end up killing off the cancer,» said Lee.

Oocytes contain a high concentration of an oocyte - specific isoform of p63 which plays a key role as a quality control factor in causing infertility.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

Each of these proteins possess several isoforms with characteristics that either mimic or antagonize the role of p53.

In the context of the current study, TRAF6's regulation of RNA isoform expression is important to the function of hematopoietic cells and reveals another dimension to how cells respond to infection, Starczynkowski said.

The p73 gene also encodes six different isoforms which range in size from 47.5 to 80 kDa [22,43].

We investigated cases of alternative splicing by retaining all the multi-exonic receptor gene models and counted the number of alternative isoforms produced.

In response to various pathogens, the protein also regulates RNA isoform expression, an important step in the translation of genetic code into protein and cell formation.

The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in stratified squamous epithelium [21,34].

Laminin - 521 induce fast migration of the cells and laminin isoform specific activation of PI3K / Akt pathway through interaction with α6β1 integrin.

These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.

Regarding other members of the p53 family, the p63 gene encodes 6 isoforms which migrate on gels in sizes from 32 - 90 kDa [21,30].

Alternative splicing affects most mammalian genes, and effectively enables the production of distinct protein variants (called isoforms) from the same gene.

The ability of Nanopore sequencing to define the complete exonic structure of CACNA1C allows us to identify known and novel gene isoforms, including novel exons and multi-exonic skipping events and their expression across multiple brain regions.

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1?a and HSF1?ß, Regulate Chaperone Protein Gene Transcription.

Wang et al. found that the ABL kinase isoforms ABL1 and ABL2 enhanced the ability of breast cancer cells to invade and break down bone in mice.

The response of interleukin - 6 and soluble interleukin - 6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling.

The TA isoforms contain a transactivating domain that is homologous to the transactivating domain of p53 [21].

Moreover, it is now apparent that muscle fiber type (as measured by the MHC isoform) can vary along the length of a single muscle fiber (Zhang & Gould, 2017).

An x-ray crystallographic structure of the Numb domain that binds to Mdm2, with the crucial stretch of 11 amino acids — only present in Numb isoforms 1 and 2 — shown in red.

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

Rao and Bredesen next used genome - wide chromatin immunoprecipitation sequencing (ChIP - seq) to determine where in the genome the two ApoE isoforms bound.

Brains from these mice contained CtmPrP but not PrPSc, the PrP isoform responsible for transmission of prion diseases.

The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is converted into the pathologic isoform PrPSc.

While the two actin isoforms differ by only four amino acids, their mRNA coding sequences differ by almost 13 percent because of «silent» nucleotide differences that nevertheless encode the same amino acids.

These changes in mitochondria - and calcium - related markers occurred without any changes in the myosin heavy chain isoform composition of these muscles, as assessed by quantitative PCR (qPCR)(data not shown).

The muscles from IL - 15Rα — KO mice had a greater relative expression of the SERCAII isoform and lower mRNA and protein levels of calsequestrin, both characteristic of slow muscles (52).

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes.

The shorter isoform binds to GluA2 via PDZ domains 3, 5 and 6 (Srivastava et al 1998).

The researchers» next step is to study the channel and transporter - like properties of VGLUT1 and its related isoform in greater detail, to see if they contributes to changes in synaptic strength that underlie learning, memory and many other aspects of cognition.