Sentences with phrase «of cell lines»

In mature and older pets, leukemia (cancer) of one of the cell lines in the marrow is a common cause.

Recent studies highlighted significant differences between these two types of stem cells, although only a limited number of cell lines of different origins were analyzed.

As names are not even used consistently in publications and deviations from the original name are not rare, the situation increasingly causes confusion about the identity of cell lines used in specific studies.

Although the creation of the cell lines was not a surprise, the availability of these cells is significant.

Cell lines are an integral part to research in many fields, and these days there are probably thousands of cell lines.

To settle the case, they analyzed the genetic sequence of the cell line at 500,000 locations across the genome.

The scientists also analyzed the genes of each cell line.

The new findings show that proper identification of a cell line also requires that the DNA profile matches the tissue of origin.

Cell lines are therefore indispensable in medical research and a large number of cell lines exist that originate from many different tumor types.

One of the key expertise of our facility is to validate the origin of cell lines.

Many top tier journals have begun to request proof of cell line authentication from investigators.

Nobody had told them, let alone explained the concept of cell lines to them.

Besides that, these drinks contain a significant amount of calcium which prevents the excessive growth of cells lining the large intestine.

Vitamin A - Vitamin A plays an essential role in the growth and repair of the cells lining the gastrointestinal tract.

Many of them work by increasing the speed of production of cells lining the ducts and cells of the skin of the face.

Approximately 20 - 30 % of all cell lines used in biomedical research are contaminated.

Previous efforts to screen potential drug combinations only analyzed use of a few drugs against a limited number of cell lines or lines in which genomic variations were poorly understood.

Our findings show that treatment of both cell lines with increasing concentrations of LY294002 led to cell cycle arrest as shown by decreased cell cycle S - phase fraction in a dose - dependent manner (Supplementary Fig.

The RPE is a single layer of cells lining the back of the retina that is vital to the functioning of the retinal photoreceptor cells, and thus vision itself.

Until 2009, Saitou's starting point had been cells taken from a live mouse epiblast — a cup - like collection of cells lining one end of the embryo that forms at the end of the first week of development, just before the PGCs emerge.

«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.

HeLa cells, with proteins labeled in blue and DNA in red, are responsible for over 20 percent of the cell line contaminations.

Determining eligibility of cell lines derived before 7 July will require «more complicated exercise of judgment,» said Kington.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

In addition to validating these cells, the group has determined the sensitivity of these cell lines to a variety of chemotherapeutic agents currently in use and proposed for use in the treatment of canine cancers.

Researchers from the University of Cambridge studied a variety of cell lines, including human neural stem cells, to investigate how Zika virus infection can lead to microcephaly.

Treatment of these cell lines with the PI3K inhibitor, LY294002, resulted in a concentration - dependent decrease of the phosphorylation levels of AKT, mTOR, 4E - BP1, p70S6K, and S6K (Fig. 2A and B).

Registration of a cell line in hPSCreg confirms ethical procurement and scientific evidence for pluripotency to the global community.

«Before, you could in principle test chemical compounds of interest against hundreds of cell lines, but it would require a lab member going to a freezer, taking out hundreds of vials — one for each cell line — and setting up hundreds of tissue culture plates.

«Alternatively, hot liquids may impair the barrier function of the cells lining the esophagus, leaving the tissue open to greater damage from other carcinogens.»

Later, during a chance discussion with European colleagues, stem cell researcher George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute learned that they had received samples of the cell line before the work was retracted.

In studies of cell lines from more than 20 Friedreich's patients, the molecular prosthesis restored expression of the frataxin protein.

From pv magazine's conversations with analysts, widespread installation of cell lines was doubtful anyway given the larger capital investments and longer lead times required.

The genome of the cell line, which originated from a deadly cervical tumor taken from a patient named Henrietta Lacks, is riddled with errors, raising questions about its continued use in research

The key is breakneck reproduction, a characteristic of the cells lining an infant's gut.

For example, butyrate is thought to reduce colorectal cancer risk by boosting the health of cells lining the intestines and prompting cancerous cells to self - destruct.

Grants issued last summer totaling nearly $ 50 million will go toward producing the first 8,500 or so of the cell lines, each carrying one disabled, or «knocked out,» gene.

In May 2001, the U.S. Justice Department charged two Japanese - born scientists with conspiring to «benefit a foreign government» by stealing trade secrets in the form of cell lines and DNA samples from a laboratory at the Cleveland Clinic Foundation in Ohio, where one had worked from 1997 to 1999 (Science, 18 May 2001, p. 1274).

«With our sequencing and transcriptional data, we can figure out which of these cell lines most closely match the human tumors.

The destruction of cells lining the gut leads to abdominal cramping, watery diarrhea, and eventually bloody diarrhea.

«The driver is really the productivity of the cell line,» Ballou says.

And, in the future, the potential to insert barcodes in genes and the development of in - line ID kits, that recognize specific strains of cell lines, could make it easier to verify new organisms and their protein products, and track products through supply chains.

Many dependencies were cancer - specific, in that silencing them each affected only a subset of the cell lines.

However, he cautioned, it is not yet clear what the properties of those cell lines are nor who owns intellectual property rights to them.