Sentences with phrase «preclinical studies»
"Preclinical studies" refer to scientific research conducted before testing new drugs or medical procedures on humans. These studies are usually performed on animals or in a lab, and help determine the safety, effectiveness, and potential side effects of the treatment. Full definition
The researchers intend to make use of their new method in preclinical studies in the future and continue to develop it — for example, applying it to infections and to rheumatological and arthritic diseases.
sciencedaily.com
Meta - Analysis of Preclinical Studies of Mesenchymal Stromal Cells for Ischemic Stroke (April 8, 2014) in Neurology.
Areas of expertise include: Medicinal chemistry for preclinical studies in the area of neurological disorders, oncology, and immunological disease.
In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.
Published new efficacy and safety data from preclinical studies of AST - OPC1 in the peer - reviewed journal «Stem Cells Translational Medicine.»
A new preclinical study led by a University of Texas at Dallas researcher shows that vagus nerve stimulation (VNS) therapy might have the potential to help people overcome drug addiction by helping them learn new behaviors to replace those associated with seeking drugs.
We have developed a novel form of the naturally occurring growth factor gastrin, which in preclinical studies demonstrated its ability to significantly improve the survival of beta cells.
«The next step is to perform preclinical studies with specific inhibitors of HDAC11 alone and in tandem with other existing immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.
In collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent need.
The findings of multiple in vivo preclinical studies published online in Blood Advances, a Journal of the American Society of Hematology (ASH), indicate that this therapy could potentially treat multiple cancers, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and acute myeloid leukemia (AML).
The George lab is currently performing preclinical studies for the future development of novel therapeutic approaches including Deep Brain Stimulation, Optogenetics, Chemogenetics and Precision medicine.
Late last year, the science ministry committed to spending nearly $ 3 million on preclinical studies of synthetic phosphoethanolamine.
Two new rounds of grants from President Barack Obama's Brain Research through Advancing Innovative Neurotechnologies Initiative this summer aim to bridge the gap between promising preclinical studies with invasive brain devices and large human trials.
«Indeed, both clinical and preclinical studies report that females require almost twice as much morphine as males to produce comparable pain relief,» said Hillary Doyle, graduate student in the Murphy Laboratory in the Neuroscience Institute of Georgia State.
Seres presented results from preclinical studies designed to evaluate the impact of various consortia of bacterial species on the anti-tumor immune response in murine models following treatment with an anti-PD-1 checkpoint inhibitor.
«New preclinical study indicates vaccine to prevent Zika infection in humans is feasible: Army scientists are moving quickly to test vaccine candidate.»
The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.
NeuroPhage's NPT088 Universally Targets Misfolded Proteins in Preclinical Studies Highlighted in Oral Session at the Alzheimer's Association International Conference
The new data builds off several preclinical studies supporting the use of ibrutinib with CAR therapy.
The findings of multiple in vivo preclinical studies published online today in BloodAdvances, a Journal of the American Society of Hematology (ASH), indicate that this therapy could potentially treat multiple cancers, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and acute myeloid leukemia (AML).
It enables scientists at Moderna's ventures and New Venture Labs, as well as our biopharma partners, to digitally design and order mRNA constructs for use in discovery research and preclinical studies through an encrypted and secure portal.
Southern Research's DART program performs complex preclinical studies to ensure that drug candidates, nutritional supplements, food additives and chemicals don't endanger unborn children and pregnant women.
Although the biotech has only conducted preclinical studies so far, there are several potential advantages to nonviral therapies, including being quicker to develop and possibly eliminating the need for a lengthy monitoring period of patients after treatment.
«There are several preclinical studies going on, and some of them may reach the clinical testing stage sometime next year,» Lu says.
In a small preclinical study, researchers studied whether the use of antibiotic - containing microspheres prevented infections in grossly contaminated wounds.
A third preclinical study (abstract 3.397) explored the anticonvulsant and tolerability profile of CBD in animal models.
Using their previously established sporadic PD mouse model, the researchers conducted both prevention and intervention preclinical studies.
After preclinical studies, a gene therapy trial for SCID - X1 was initiated, based on the use of complementary DNA containing a defective γc Moloney retrovirus — derived vector and ex vivo infection of CD34 + cells.
Verma, whose team will publish its findings tomorrow in Nature, says the findings emphasize the need for longer preclinical studies.
ReNeuron says that the concerns are readily addressable and that preclinical studies now underway should answer the FDA's questions.
An earlier preclinical study found that rhesus monkeys that were vaccinated with ZPIV developed a strong immune response and were protected against two strains of Zika virus.
While preclinical studies suggest that this treatment may be effective, long - lasting and well - tolerated, the study now underway at Roswell Park marks the first time this strategy will be assessed in humans.
In in vitro preclinical studies, NPT088 showed potent and selective binding to Aβ and tau aggregates.
Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo).
Host: Dr. Tim Murphy Speaker: Dr. Leonard Khiroug, Neurotar Title: In vivo two - photon imaging of fluorescently - labeled macromolecule penetration through blood - brain barrier: applications in Pharma preclinical studies
In 2008, several CRI investigators were part of a multi-institutional preclinical study showing that treatment with the immune activating molecule interleukin 15 (IL - 15), when complexed with its receptor, could trigger rapid regression of established pancreatic cancers and significantly prolong survival.
These new preclinical studies provide support for advancing the Ad26 / MVA prime - boost vaccine candidate into clinical development.
A recent preclinical study that involved an experimental oligonucleotide drug similar to SMNRx found that waiting to administer the therapy drastically reduced its effectiveness.
«The model system we have developed will be extremely useful to reveal the mechanisms that cause this cancer to progress and to study the different options for potential therapeutic interventions before proceeding to more advanced preclinical studies,» Roussel said.
In this study, we clinically tested a therapeutic platform that we have previously described in preclinical studies [12] in which B cells from NHL dogs are expanded in vitro using CD40L transfected K562 cells (KtCD40L) and then loaded with autologous tumor RNA to generate a cell - based vaccine.
Tags for this Online Resume: Microscopy, Medical Device, Translational Research, Assay Development, Cancer Diagnostics, High resolution endoscopy, Tissue Microscopy Imaging, In vivo animal imaging, Low cost diagnostics, Grant Writing, Preclinical studies coordination, Scientific Writer
ABSTRACT: Craving, defined as the subjective experience of an urge or desire to use substances, has been identified in clinical, laboratory, and preclinical studies as a significant predictor of substance use, substance use disorder, and relapse following treatment for a substance use disorder.