Sentences with phrase «regulation of genes»

This interaction is thought to be important in regulation of gene expression.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

It is an important factor for the correct regulation of gene expression within all these groups of organisms.

In other words, there is more complex regulation of genes, and more rapid evolution of these regulatory elements, in humans?

Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes.

The group also develops new compounds targeting the epigenetic regulation of gene function.

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Protein complexes, epigenetic regulation of gene expression and cancer.

The newly identified variation is found in the region of IFITM3 involved in regulation of gene expression through the binding of proteins and other chemicals that promote or suppress gene activity.

For example, the study found down - regulation of genes involved in interferon tau, the major signal of pregnancy recognition.

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

Methyl labels in the DNA play a key role in this «epigenetic» regulation of gene activity.

Thus, the discovery of DNA methylation in early diverging fungi helps the research community better understand regulation of genes that encode the parts for bio-based economy and bioenergy applications.»

At the nucleic acid level, understanding the precise regulation of genes through analysis of gene expression data will be of utmost importance.

The work described here has established the framework for the future systematic characterization of the global program and molecular mechanisms of post-transcriptional regulation of gene expression in any genetically tractable organism.

They write that the U.S. National Academy of Sciences has recently convened a panel to discuss the potential hazards and regulation of gene drives, and to make recommendations regarding their safe use.

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers.

The Morris lab has since determined the mechanistic underpinnings of non-coding RNA mediated regulation of gene transcription in human cells, with evidence suggesting a role for longer forms of non-coding RNAs as endogenous effectors involved in epigenetically remodelling target loci in human cells.

Embryonic development is a well - studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner.

In this review article, we highlight transcriptional regulation of gene expression in response to drought.»

The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

People with autism appear more likely to have atypical regulation of the gene that codes for the oxytocin receptor, the protein that determines how well the body responds to the hormone.

Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day regulation of our genes

Cavalli and his team at the Institute of Human Genetics (University of Montpellier / CNRS) are the first to show that regulation of gene position can lead to transgenerational inheritance.

«Novel regulation of gene expression in brain tumors identified.»

In cancers, both gene mutations and aberrant regulation of genes (promoter inhibition by methylation of DNA) are known to play pivotal roles regulating cancer growth.

Calcium is in fact an important signal - molecule that actually ties together an outer stimulus to an inner regulation of genes.

«We could take out a patient's subcutaneous fat with a simple needle biopsy, modify the fat cells to make the microRNAs that we want, put the cells back into the patient, and then hope to get regulation of genes that the patient is not regulating normally,» he suggests.

«We looked at regulations of genes, rather than genes themselves, and whether the gene is expressed in certain tissues or how much the gene is expressed there.

During a segment on Yamanaka's research, one of these animations is particularly useful in explaining how chromatin regulation of gene expression is different in different types of tissues.

Finally, Yingjie Guan, assistant professor (research) of orthopaedics at Brown and Lifespan, at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.

Abundant RNA - binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Research Interests: RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

These studies will lead to in - depth investigations of tumor heterogeneity and the dynamic regulation of genes that define subpopulations with specialized biologic functions.

During these past ten - plus years, he has advanced computing at HMS, expanded SBGrid beyond X-ray crystallography to include electron microscopy and nuclear magnetic resonance imaging, and launched an independent research lab focused on microRNA regulation of gene translation.

Other molecular mechanisms linking the cloned 13.5 kb ws1 region to wing size evolution could also occur, including cis - regulation of prospero, changes in non-coding RNAs, or long - distance regulation of another gene.

«Gene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Karpen.

Importantly, there is a clear signature of the parents» sensitivity to high CO2 in the molecular phenotype of the offspring expressed by the differential regulation of genes controlling the circadian rhythm indicating adaptive potential through natural standing variation.

Since SP1 is an activator of transcription [45], the deletion of an SP1 site should result in down regulation of gene expression.

According to the findings it seems that regulation of gene activity is dependent on stuctural changes in the cell chromatine.

To determine whether shifts in the balance of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and regulation of genes involved in anterior - posterior patterning in pectoral fins of catsharks, with those of mice.

As RNA - binding proteins are still systematically understudied, we will provide important insights of the roles of a key player in post-transcriptional regulation of gene expression.

The fact that a large number of genes are responsive to the effects of TSA and L - methionine implies that the epigenetic regulation of gene expression as a function of maternal care may be extensive.

The Lazar lab has been working on HDAC3 for over a decade, focusing on the pivotal role of this enzyme in hormone - mediated regulation of gene expression and metabolism.