Sentences with phrase «specific cell types»

In particular, they are now looking for expertise in molecular biology, especially in virus - based techniques for introducing new genes into specific cell types in the grid - cell circuit.

When this occurs, the naive stem cells undergo a critical change as they take the first step toward differentiating into specific cell types, such as gut, muscle or nerve cells.

They can be induced into becoming specific cell types, depending upon need.

«Being able to selectively target specific cell types opens up a new world for understanding how to design therapies to treat disease,» she says.

However, it has been difficult to pinpoint which genetic changes are truly relevant to disease, or in what specific cell types the genetic variation has the largest effect on one's health.

They do so by responding to a variety of time - and location - specific cues within the developing embryo that direct them to become specific cell types.

The sorting of individual cells is necessary for many biological applications, including the isolation of specific cell types from cell suspensions.

«For this project, we used SPLiT - seq to profile more than 150,000 cells in the developing mouse brain and spinal cord, and we defined many new molecular markers for specific cell type,» said Georg Seelig, a synthetic biologist at the Department of Electrical Engineering and the Paul G. Allen School of Computer Science and Engineering at the University of Washington.

The team currently is exploring the cellular and molecular mechanisms underlying ischemic preconditioning using mice in which HIF - 1 activity has been knocked out in specific cell types within the heart.

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

This finding suggests their approach could be tailored to generate specific cell types for patients with different types of hypopituitarism.

To overcome these hurdles, Bhatia and her team reprogrammed human skin cells into induced pluripotent stem cells (iPSCs)-- embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease.

The cryostat sections were immunoreacted overnight at 4 °C with primary antibodies to label specific cell types and nerve fibers: GFP to label 5 - HT3AGFP containing nerve fibers, GNAT3 (gustducin) to label a subpopulation of type II taste cells, P2X3 to label nerve fibers, and 5 - HT to label serotonin - accumulating type III taste cells.

This paper provides a new method for selective inactivation the NMDA receptors in specific cell types using a novel pharmacogenetic methodology.

With these findings, Plath's lab plans future studies to actively isolate specific cell types during specific stages of reprogramming.

Each of us develops from an unspecialized single cell into hundreds of different specific cell types.

Progenitor cells are early descendants of stem cells that can differentiate into one or more specific cell types.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

Many scientists try to create specific cell types in vitro by bombarding stem cells with signalling molecules and then picking through the resulting mixture of mature cells for the ones they want.

We hope that this tool will help researchers gain new biological insights from transcriptome datasets in the future and provide information for diseases that affect specific cell types.»

«It can help us to eventually answer the question of how our body knows how to make specific cell types that can fight infection.»

Different GPCRs showed up on different neurons, allowing the scientists to parse specific cell types that might direct particular vagus nerve functions.

«We hope this atlas will be a roadmap for the field to explore the relationship between specific cell types, signaling pathways, receptors, and the physiological function of brain circuits,» Kriegstein added.

«Each cell in the kidney seems to have a unique non-redundant function, and dysfunction of specific cell types present with specific symptoms in people.

Another example being explored by Wong and others is to engineer stem cells so they develop into specific cell types when prompted by different signals.

iPSCs directed to differentiate into specific cell types offer the possibility of a renewable source of replacement cells and tissues to treat ailments, including Parkinson's disease, spinal cord injury, heart disease, diabetes, and arthritis.

This strategy enabled the researchers to track and capture specific cell types as primed cells were reprogrammed to naïve cells, including at a much earlier time point and with better sensitivity than was previously possible.

specific cell types allows exact precise separability of potential hypotheses.

«In the future, this will move us towards a way to understand how to generate a cardiac muscle or other specific cell type without having to try an unwieldy number of cell culture conditions.»

Following the delineation of some of the basic principles behind bud formation, the researchers then whether they could extend this strategy beyond the liver, and create other organ buds using tissue specific cell types.

«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.

They are the only means to target and manipulate specific cell types (populations) within neuronal networks in living animals.

The co-incidence of these 2 pathologies occurs also in humans suggesting a common pathological mechanism moving across the gut - joint axis, with TNF signals acting on specific cell types directing pathogenesis at two different locations.

Several of our research projects are designed to advance understanding of the genetic mechanisms whereby specific cell types fulfill the unique functions of building our skeleton during embryonic and postnatal development and maintaining it through adulthood.

«Ideally, specific cell types within these circuits could be targeted in order to shift attention away from unhealthy cues such as high - calorie food cues.

The system, originally developed in 2007 and refined by Wall and Callaway for targeting specific cell types in 2010, uses a modified version of the rabies virus to «infect» a brain region, which in turn targets neurons that are connected to it.

McKay's laboratory studies the process by which stem cells become specific cell types, known as differentiation.

We have designed chemical linker systems for use with selected ligands that enable the targeting of specific cell types.

New research from a team in the Perelman School of Medicine at the University of Pennsylvania shines a light on specific cell types that drive normal or diseased kidney function at the molecular level.

Prerana Shrestha is studying the role of translation in specific cell types in amygdala for fear related memory processes.

In the future, the team is interested in addressing what other consequences this signaling pathway has for specific cell types, according to Sébastien Herzig, the other first author of the paper and a Salk research associate.

GAGE: One limitation is we haven't differentiated the cells into specific cell types — neuronal subtypes.

«Normally, stem cells differentiate into many different cell types and it's difficult to get them to produce a good amount of any one specific cell type,» Lin said.

«That doesn't mean the other cues are irrelevant; they may still push the cells into a specific cell type.

«This is exactly the technology you could use to look for epigenomic changes in specific cell types,» says Martienssen, who is also on the International Human Epigenome Consortium's steering committee.

Bioengineers at the University of California, San Diego have proven that when it comes to guiding stem cells into a specific cell type, the stiffness of the extracellular matrix used to culture them really does matter.