Sentences with phrase «type mice»

«Early during pregnancy, if the mother is infected, there is significant impact on the fetus, even in wild type mice,» she noted.

We tested this hypothesis by housing 2 - month - old wild - type mice with or without running wheels for 3 — 4 weeks.

Numbers represent percent increases relative to wild type mice and were calculated from the data shown in Table 1.

The wild - type mice didn't develop colitis, but showed low - grade inflammation in their intestines and several features of metabolic syndrome: slight weight gain, increased body fat and food intake, and higher blood sugar levels, which indicate poor glucose regulation associated with diabetes.

Liliana M.; El - Khodor B F.; Hornberger M.; Park, Larry; Howland, David; Brunner D. Effect of the rd1 mutation on motor performance in R6 / 2 and wild type mice [Internet].

The researchers found that mice without the RGS6 protein consumed less alcohol than wild - type mice when given free access.

'' (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses)» - Michael

In wild - type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ - mediated increase in inducible nitric oxide synthase expression.

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

To aid research into potential new treatments, Jane Wilson and Natalie Prow of QIMR Berghofer Medical Research Institute, Australia, and colleagues exploited an adult wild - type mouse model of chikungunya virus infection and diseases previously developed by the group.

«None of the neurotrophic factor manipulations influenced amyloid deposition, while they all had effects on memory function, also in wild - type mice without amyloid beta pathology,» says Susanna Kemppainen, MSc, who presented the results in her doctoral thesis.

After intracerebral injection of the recombinant prion, wild - type mice developed neurological signs in ~ 130 days and reached the terminal stage of disease in ~ 150 days.

(Left) Blood smears from anemic mice indicate irregular shapes of red blood cells; (right) wild type mice indicate normal shapes of red blood cells.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Previously, it has been found that knockout mice lacking both copies of SIRT1 displayed a shorter median lifespan compared with wild - type mice on an ad libitum diet 12.

Isolated wild - type mouse liver mitochondria efficiently imported those constructs that included the appended RP sequence, and cleaved their transcript terminus sequences in line with normal mRNA maturation.

You can see that wild - type mice under a high - fat diet increase weight, and these are up to ten weeks of feeding you could see a significant rise in body weight, but this is attenuated quite significantly when you knock out PTP1B.

The mRNA was not detectable in normal wild - type mouse mammary gland (Figure 1A).

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

Wild - type mouse microglia respond in a dose - dependent fashion to HS - oligosaccharides isolated from MPS IIIB patients with overexpression of macrophage inflammatory protein 1α (Mip1a or Ccl3) and interleukin 1β mRNAs.

Both obese humans and mice have significantly elevated soluble Fabp4 / aP2 levels, and injection of recombinant Fabp4 / aP2 into lean wild type mice stimulates hepatic glucose production and gluconeogenesis.

As shown in Fig. 5B, thymocytes from wild - type bone marrow developed normally in irradiated Gasp − / − mice, whereas wild - type mice reconstituted with Gasp − / − bone marrow showed almost identical phenotypes as Gasp − / − mice.

Fans can pose a question or request to Pikachu, and the much - loved Electric - type Mouse Pokémon will respond with classic lines like «pika?»

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Duke University Medical Center researchers led by Kyle Allen found that collagen deficient mice prematurely developed common and chronic musculoskeletal disorders while the wild - type mice did not.

Menalled L, El - Khodor B.F, Hornberger M, Park Lm Howland Dm Brunner D. Effect of the rd1 mutation on motor performance in R6 / 2 and wild type mice [Internet].

Those mice were unsuccessful with context fear conditioning, but they did as well as wild - type mice when they were treated with memantine.

And the claim typically persists for decades once widely - cited, despite the best efforts of serious investigators to critique weak methodologies and flawed interpretation, or even robust demonstrations of a null effect in healthy animals (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses).»

Investigators at the National Institute on Aging compared wild type mice with specially bred mice that were transgenic for the A53T mutation of the human α - synuclein (SNCA) gene under the control of a human thymus cell antigen 1, theta (THY - 1) promoter.

Donor T cells adopted a tolerant state in wild - type mice, but not in gp96 knockout mice.

This prolonged presence of the virus has not been observed in other sites of infection in wild - type mice, she said.

At about 24 weeks, however, seventy percent of them developed spontaneous colitis, while none of the wild - type mice did.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

After isolating these stem cells from both transgenic and wild - type mice, the researchers found that those carrying the HMGA1 transgene multiplied far more rapidly, forming identical daughter cells in a process called self - renewal, which is a defining property of all stem cells.

What surprised us most was that the virus replicated in the vagina of wild - type mice with intact interferon response,» said Iwasaki.

These organoids had more stem cells than those isolated from wild - type mice.

Mice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type mice.

More inflammatory - type T cells and less tolerant - type T cells were found in the colon of mice without gp96 as compared to wild - type mice.

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.