Sentences with word «kinase»
A kinase is a type of enzyme found in the human body that helps to activate or deactivate certain proteins by adding a phosphate group to them. This process is important for regulating various cellular functions and signaling pathways in our cells. Full definition
The jury remarked that the three laureates have participated independently in a chain of advances running from «the basic discoveries of tyrosine kinase proteins to clinical applications that save lives.»
salk.edu
Complete remission with tyrosine kinase inhibitors in renal cell carcinoma.
A number of kinase inhibitors in the clinic for the therapy of lung cancer have more than a single protein target.
These findings revealed a role for ABL kinases in regulating tumor - bone interactions and provide a rationale for using ABL - specific inhibitors to limit breast cancer metastasis to bone.
Similarly, inhibiting ABL kinase activity with the allosteric inhibitor GNF5 decreased TAZ protein abundance (fig.
P significantly increased hypothalamic cAMP levels and cAMP - dependent protein kinase activity.
In this theory it is explained that cutaneous melanoma occurs mainly due to DNA damage involving the region of cyclin dependent kinase inhibitor 2A gene (CDKN2A), as a result of exposure to excessive amounts of ultraviolet (UV) radiation from sunburn in early stages of life [25].
Subjects can be enrolled from a local test result if they have any of the following FLT3 mutations: FLT3 internal tandem duplication (ITD), FLT3 tyrosine kinase domain (TKD) / D835 or FLT3 - TKD / I836.
The Penn researchers found that the fungal toxins activate protein kinase C (PKC), which decreases ciliary beat frequency and thus decreases MCC.
DMD can be detected through high levels of a protein called creatine kinase in the blood stream, and is confirmed by genetic testing.
Duration and strength of extracellular signal - regulated kinase signals are altered during positive versus negative thymocyte selection.
Role of the p38 Mitogen - Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide — Dependent Cellular Responses
Normally the Janus Kinase family of enzymes is needed in the transmission of information to the cell nucleus, leading to the transcription of the cell's DNA and the expression of its genes.
The researchers from Halle have now figured out that the already familiar MAP kinase signalling pathway plays a central role.
Winship Cancer Instituteâ $ ™ s Ned Waller and researchers from Childrenâ $ ™ s Healthcare of Atlanta and Yerkes National Primate Research Center were part of a recent Science Translational Medicine paper that draws a bright red circle around aurora kinase A as a likely drug target in graft - vs - host disease.
Somalis, like Abyssinians, could develop a hereditary health issue called pyruvate kinase deficiency causing intermittent anemia.
Fructose selectively modulates c - jun N - Terminal kinase activity and insulin signaling in rat primary hepatocytes..
It inhibits two tyrosine kinase enzymes called Jak1 and Jak2, which rev up production of immune cells.
This review focuses on kinase inhibitors that are in the clinic or in clinical trials and for which structural information is available.
We induced differentiation of hPSCs into the mesodermal lineage by culturing on collagen - coated plates with a glycogen synthase kinase 3β inhibitor.
Given this observation, we hope that the off - target effects on Aurora kinase B and ERBB2 (if any) will also be in a vastly different concentration range of 100 nM.
High humidity suppresses ssi4 - mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression
These techniques enable Burke and his lab to elucidate the structure and function of the lipid - targeting kinases at the cell's plasma membrane, a complex bilayer of lipids, proteins and carbohydrates that separates the cell's internal space from the external environment.
Investigated TAM family receptor tyrosine kinase gene expression in response to small molecule inhibitors in glioblastoma multiforme
These receptors have been used in bacterial biosensors, where re-designed PBPs were linked to gene expression through a histidine kinase signaling pathway [5].
Resveratrol is also known to inhibit numerous pro-inflammatory actors, messengers and chemicals, including sphingosine kinase, COX - 2, NF - KappaB and phospholipase D (which is great news for acne).
One mechanism is protein synthesis by key regulators such as S6 kinase (S6K).
Serum thymidine kinase activity in canine splenic hemangiosarcoma.
The addition of the Rho - associated kinase inhibitor [20] prior to and during the sorting procedure enable the analysis of the fate of single cells by a colony formation assay.
Rb and E2F remain bound together as a result of cyclin dependent kinase inhibition.
mTOR, ATR and other related kinases do not work in isolation but rather by interacting and forming complexes with other proteins, which are essential for their normal functioning.
The overall picture Heinemann and his colleagues have sketched in the Molecular Cell article is a system, in which the metabolic oscillator pulls the cyclin - dependent kinase complex through its cycle and dynamically gate the occurrence of the different cell cycle events.
The main body of his research has been to delineate the mechanisms by which the serine / threonine kinase Akt affects tumorigenesis and metabolism, both at the cellular and organismal levels.
Of the more than 1,600 samples tested, 10.5 % had EGFR sensitizing, 18.8 % EGFR resistance, 13.2 % KRAS, and 2 % EML4 - ALK (anaplastic lymphoma kinase) mutations.
We can clearly observe RIPK2 inhibitor 1 and 2 inhibition of MDP - dependent activation of RIPK2 autophosphorylation (on tyrosine 474) using an in vitro kinase assay in HCT116 cells (Fig. 3B).
There are over 500 known human kinases and 10s of thousands of possible proteins they can target.