This cross section of a lymph node shows that the molecular vaccine (green) has been taken up
by immune cells in the lymph node.
It then passes through the intestinal wall and is
met by immune cells that would normally kill it.
Further experiments suggested that the production of high levels of cell wall - associated GAG makes A. fumigatus more resistant than A. nidulans to neutrophil killing by neutrophil extracellular traps, or NETs (NETs are are networks of extracellular fibers, composed of DNA and proteins secreted
by immune cells called neutrophils, that bind and trap various pathogens).
Some researchers suggest that our bodies can become addicted to the chemical messengers such as histamine or cortisol which are
secreted by immune cells in response to allergens in the body.
In a study involving human cells, researchers at the University of Edinburgh have shown that alpha defensins are
released by immune cells called neutrophils when they die.
In a previous investigation, the scientists discovered that 95 % of cell death from HIV is
caused by immune cells committing suicide in self - defense after an unsuccessful infection.
The favorable results are due in large part to the advances in managing severe graft versus host disease (GVHD), an attack on the patient's normal tissues
by immune cells of the donor.
Several Gladstone scientists study abnormal inflammatory
responses by immune cells in the central nervous system, which may contribute to the progression of multiple sclerosis, neurodegenerative disorders and many other neurological conditions.
On the other hand, a highly reactive form of oxygen called superoxide is created
by immune cells from O2 to use against invading microbes.
«We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms
used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain, and other organs.
Slusher teamed up with Johns Hopkins Kimmel Cancer Center immunologist Jonathan Powell, M.D., Ph.D., who has studied how cancer cells use different metabolic pathways to evade
destruction by immune cells.
Mammals are known to fend off viruses with a system based on interferons, signaling proteins
made by immune cells that amplify the body's attack on invaders.
The main role here is
played by immune cells migrating from the blood into the tissue to fight the inflammation.
Resolvin D - 1 is a bioactive mediator produced
by immune cells for cell - to - cell signaling, and it is part of the natural innate immune response that resolves inflammation.
In the brain, a synapse (orange) is seen being wrapped around and
attacked by immune cells called microglia (green), leading to synapse loss.
This contact causes the LDL lipoprotein to be oxidized, after which the particle attaches to macrophage scavenger receptors and is
cleared by immune cells.
The researchers determined that the alveolar epithelial cells are typically protected from influenza
infection by immune cells called alveolar macrophages.
Keytruda, formerly known as MK - 3475, is an antibody that targets a protein called PD - 1 that is
expressed by immune cells.
The scientists tracked the cytoskeletons of endothelial cells as they were
crossed by immune cells in real time, the behavior of the nuclei of various white blood cells during active squeezing, and the fate of the various types of actin fibers that make up the endothelial cell skeletons.
The inflammatory response
generated by the immune cells caused brain swelling, which is particularly risky near the thalamus, a structure buried deep inside the brain, the researchers reported.
Outside of the brain, cytokines are released
by immune cells fighting infections, and they can alter MHCI expression in a complicated feedback loop.
In lab tests, the CpG - antigen package, at 300 nanometers in size, was absorbed 90 percent of the
time by immune cells, the UI - led team reports.
Patients can succumb to bacterial infections because their immune systems lack a molecule
required by immune cells, specifically neutrophils, to go to the site of infection.
They have identified a «checkpoint»
manned by these immune cells that, if barred, can halt the development of the lung inflammation associated with allergies.
The Harvard researchers began by analysing the three - dimensional structure of the small region of the nerve cell sheath protein that is
targeted by immune cells in MS patients.
Most of the time when the heart is injured, these beneficial immune cells are
supplanted by immune cells from the bone marrow, which are spurred to converge in the heart and cause inflammation that leads to further damage.
Some have proposed that age - associated inflammation is caused by accumulating wear and tear on our immune cells, while others have suggested that it is caused
by immune cells dealing with chronic viral infections.
Activin A is generated after exactly these sorts of bumps — the protein is churned out
by immune cells when there is an injury.
IL - 6 is a cytokine, a signal molecule that is produced and secreted
both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.
Building on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released
by immune cells involved in fighting the infection.
Study co-author Thomas Moeller, a neurologist at the University of Washington in Seattle, speculates that the cytokines — which are also produced in
excess by immune cells in the brain called microglia — may be killing or contributing to the death of healthy neurons, leading to symptoms down the road.
In animal studies, exosomes secreted
by immune cells during environmental enrichment caused cells in the brain to start myelin repair.
Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar
space by immune cells.
The altered methionine metabolism leads to activation of oncogenes, while the changes in tryptophan metabolism shield GBM cells from
detection by immune cells.
From an evolutionary perspective, Freeman said SARM and Axed function are likely important in the peripheral nervous system after injury because programmed axon death allows for efficient packaging of damaged cellular materials for
removal by immune cells.
To pin down what caused the animals» low spirits, the researchers measured levels of cytokines, signaling molecules that can be released by tumors or
by the immune cells battling them.
In mice suffering from liver cirrhosis, the scientist observed a sustained production of Type - 1 interferon in response to the intestinal
bacteria by immune cells responsible for defense against infection, namely macrophages and monocytes in the liver.
Scientist at the University of Bonn and TU Munich have now discovered that type I IFN released
by immune cells due to increased migration of gut bacteria into the cirrhotic liver incapacitate the immune system.
Too large a dose can cause congestive heart failure, among other side effects, while a small dose may be
overwhelmed by immune cells, which consider doxorubicin a foreign invader.
With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor
infiltration by immune cells).
The molecule, called microRNA 29b, would be ineffective if delivered by injection alone, as it quickly becomes degraded in the bloodstream or picked up and
removed by immune cells.