Sentences with phrase «gene silencing»
Anti-sense oligonucleotides or ASOs are one type of gene silencing drug, made from a DNA - like chemical.
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It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).
«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»
This RNA message molecule is the target of gene silencing drugs.
«The Chp1 - Tas3 core is a multifunctional platform critical for gene silencing by RITS,» appears in Nature Structural and Molecular Biology on November 13.
We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.
In addition, A-to-I RNA editing is involved in control of the expression and function of microRNA (miRNA), which is a small RNA essential for the RNAi mediated gene silencing mechanism.
A major effort in the lab is to elucidate the active components of this process and to apply transcriptional gene silencing in a therapeutic setting.
McKay and Tsai turned off production of the gene's protein through a technique known as gene silencing, and in other cases they added extra protein to the cells.
In the Baulcombe lab, Voinnet analyzed the in vivo dynamics of gene silencing using transgenic plants, recombinant viruses, and fluorescence microscopy.
In this episode, Dr. Carlos Faraco speaks with Dr. Don Cleveland of the University of California San Diego regarding his work on drug - based gene silencing therapies.
The current ASO trial in humans is a huntingtin lowering, or gene silencing therapy, which works to disable both copies of the HD gene in short bursts.
One such regulatory process is RNA interference (RNAi), in which a small double - stranded RNA triggers gene silencing.
A 14 - year search for the cause of a rare genetic disease that strikes young girls has uncovered the first example of a human disease that is linked to a defective gene silencing mechanism.
After receiving a PhD in molecular genetics and gene silencing from Pierre and Marie Curie University Paris, I joined as a postdoc the laboratory of Frederic Rosa at Ecole Normale Superieure Paris to investigate the genetic basis of vertebrate development.
Today brings news that the first Huntington's Disease patients have been successfully dosed with gene silencing drugs targeting the HD gene.
But now, in a study appearing in the May 11 issue of Nature Nanotechnology, an MIT - led team reports achieving the most potent RNAi gene silencing to date in nonliver tissues.
What's more, it can be given with a simple injection into the blood, offering great potential for research in gene silencing research and beyond.
Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.
You might also hear this approach called gene silencing, but huntingtin - lowering is more accurate, as we'll explain.
Comprehensive transcriptome analyses reveal tomato plant responses to tobacco rattle virus - based gene silencing vectors
We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47 - base 3» untranslated region motif is implicated in this process.
The SGN VIGS Tool: User - Friendly Software to Design Virus - Induced Gene Silencing (VIGS) Constructs for Functional Genomics
«Huntington's disease gene dispensable in adult mice: Implications for treatment approaches involving gene silencing.»
In contrast, other gene silencing drugs with names like RNA interference, siRNA or shRNA, need to be injected directly into the substance of the brain and don't spread very far without help.
By applying gene silencing techniques to experimental design, experts have delimited several periods of the regeneration process in which gene function is determinant.
In RNA - directed gene silencing in worms, an unanticipated class of small antisense RNAs is synthesized by cellular RNA - directed RNA polymerase.
Determined to investigate, Voinnet specialized in plant molecular biology and, because gene silencing had also been reported in plants made resistant to viruses, plant pathology.
Gene silencing remains a quirky field that requires «a particular state of mind,» Voinnet says.
«David [Baulcombe]'s group developed a number of very interesting gene silencing systems at the time and Olivier was very good at seeing connections between these and designing elegant experiments to test them,» Hamilton, today a lecturer at the University of Glasgow in the United Kingdom, writes in an e-mail.
UMD scientists have discovered a mechanism for transgenerational gene silencing in the roundworm Caenorhabditis elegans.
The best of these compounds, known as cKK - E12, achieved gene silencing five times more efficiently than that achieved with any previous siRNA delivery vehicle.
«Better RNA interference, inspired by nature: New nanoparticles offer best - ever gene silencing.»
Importantly, the small remnants of the messenger RNA can then function like additional microRNAs, binding to other copies of the messenger RNA, causing further gene silencing.
And many companies began to crumble: While gene silencing was simple in worms, mammals proved to be far more complex — and safe drug delivery emerged as a major problem.
In two new studies, a team of researchers led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has gained insight into the structure of PRC2 and the ways in which it is regulated to affect gene silencing.
Tycko is examining gene silencing in PEG - 1, a growth - factor gene that's active in the placenta and in the development of the fetus.
This next generation could shake up what has become a stalled debate — call it the Roundup Ready stalemate — by introducing GM crops that, for example, use only their species» native genes or have the expression of their own genes silenced.
«If cells with a certain gene silenced disappear, for example, it means that gene is essential for proliferation.»
First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.
Dr Carroll, who edited the article, has previously undertaken RNA - targeted Huntington's disease gene silencing research, and is named in an associated patent.
In the future, such strategy of highly parallel gene silencing will then be adapted to progenies derived from other - PGD - derived hES cells for which biomarkers are identified.
The polycomb machinery maintains gene silencing throughout development.
How HD gene silencing is supposed to work.
Moreover, CXCR4 gene silencing using small interfering RNAs (siRNA) inhibits breast cancer metastasis in mouse models [36].